All Outputs (7)

Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation (2015)
Journal Article
Chang, P., Kuchipudi, S. V., Mellits, K., Sebastian, S., James, J., Liu, J., …Chang, K. (2015). Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation. Scientific Reports, 5(17999), https://doi.org/10.1038/srep17999

Pigs are evidently more resistant to avian than swine influenza A viruses, mediated in part through frontline epithelial cells and alveolar macrophages (AM). Although porcine AM (PAM) are crucial in influenza virus control, their mode of control is u... Read More about Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and proinflammatory dysregulation.

Extended 2D myotube culture recapitulates postnatal fibre type plasticity (2015)
Journal Article
Sebastian, S., Goulding, L., Kuchipudi, S. V., & Chang, K. (in press). Extended 2D myotube culture recapitulates postnatal fibre type plasticity. BMC Cell Biology, 16(1), https://doi.org/10.1186/s12860-015-0069-1

Background: The traditional problems of performing skeletal muscle cell cultures derived from mammalian or avian species are limited myotube differentiation, and transient myotube persistence which greatly restricts the ability of myotubes to undergo... Read More about Extended 2D myotube culture recapitulates postnatal fibre type plasticity.

PA-X is a virulence factor in avian H9N2 influenza virus (2015)
Journal Article
Gao, H., Liu, J., Kong, W., Sun, H., Pu, J., Chang, K., …Wang, J. (2015). PA-X is a virulence factor in avian H9N2 influenza virus. Journal of General Virology, 96(9), https://doi.org/10.1099/jgv.0.000232

H9N2 influenza viruses have been circulating worldwide in multiple avian species, and regularly infect pigs and humans. Recently, a novel protein, PA-X, produced from the PA gene by ribosomal frameshifting, was demonstrated to be an antivirulence fac... Read More about PA-X is a virulence factor in avian H9N2 influenza virus.

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity (2015)
Journal Article
Gao, H., Sun, Y., Liu, X., Sun, H., Hu, J., Wang, J., …He, Q. (2015). Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity. Journal of General Virology, 96(8), https://doi.org/10.1099/vir.0.000143

The PA-X protein, arising from ribosomal frameshift during PA translation, was recently discovered in influenza A virus (IAV). The C-terminal domain ‘X’ of PA-X proteins in IAVs can be classified as full-length (61 aa) or truncated (41 aa). In the ma... Read More about Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity.

Investigation into the animal species contents of popular wet pet foods (2015)
Journal Article
Maine, I. R., Atterbury, R. J., & Chang, K. (2015). Investigation into the animal species contents of popular wet pet foods. Acta Veterinaria Scandinavica, 57(1), https://doi.org/10.1186/s13028-015-0097-z

Background: The use of the generic term “meat and animal derivatives” in declared ingredient lists of pet foods in the European Union is virtually universal. In the wake of the 2013 “horse meat scandal” in the human food chain, we examined the presen... Read More about Investigation into the animal species contents of popular wet pet foods.

DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells (2015)
Journal Article
Kuchipudi, S., Chang, K., & Dunham, S. (2015). DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells. Genomics Data, 4, 60-64. https://doi.org/10.1016/j.gdata.2015.03.004

The data described in this article pertain to the article by Kuchipudi et al. (2014) titled “Highly Pathogenic Avian Influenza Virus Infection in Chickens But Not Ducks Is Associated with Elevated Host Immune and Pro-inflammatory Responses” [1]. Whil... Read More about DNA microarray global gene expression analysis of influenza virus-infected chicken and duck cells.

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses (2015)
Journal Article
Gao, H., Sun, Y., Hu, J., Qi, L., Wang, J., Xiong, X., …Liu, J. (in press). The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses. Scientific Reports, 5(1), https://doi.org/10.1038/srep08262

PA-X is a novel protein encoded by PA mRNA and is found to decrease the pathogenicity of pandemic 1918 H1N1 virus in mice. However, the importance of PA-X proteins in current epidemiologically important influenza A virus strains is not known. In this... Read More about The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses.