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Quantification of the effect of in-utero events on lifetime resilience in dairy cows (2024)
Journal Article
Lewis, K., Shewbridge Carter, L., Bradley, A., Dewhurst, R., Forde, N., Hyde, R., …Green, M. (2024). Quantification of the effect of in-utero events on lifetime resilience in dairy cows. Journal of Dairy Science, https://doi.org/10.3168/jds.2023-24215

Currently, the dairy industry is facing many challenges that could affect its sustainability, including climate change and public perception of the industry. As a result, interest is increasing in the concept of identifying resilient animals, those w... Read More about Quantification of the effect of in-utero events on lifetime resilience in dairy cows.

Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. (2023)
Journal Article
Leach, K. A., Holsey, H. J., Bradley, A. J., & Green, M. J. (2023). Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021. Veterinary Record, Article e3605. https://doi.org/10.1002/vetr.3605

Background: Achieving a reduction in mastitis in dairy cows is a common industry goal, but there is no recent peer-reviewed record of progress in the UK. Methods: A convenience sample of 125 herds in England and Scotland was recruited based on the qu... Read More about Improvement of mammary gland health in 81 'sentinel herds' in England and Scotland between 2012 and 2021..

Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments (2022)
Journal Article
Speksnijder, D. C., Hopman, N. E. M., Kusters, N. E., Timmerman, A., Swinkels, J. M., Penterman, P. A. A., …Zomer, A. L. (2022). Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments. Scientific Reports, 12, Article 15083. https://doi.org/10.1038/s41598-022-15558-z

Selection and spread of Extended Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae within animal production systems and potential spillover to humans is a major concern. Intramammary treatment of dairy cows with first-generation cephalospo... Read More about Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments.

Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis (2021)
Journal Article
Esener, N., Guerra, A. M., Giebel, K., Lea, D., Green, M. J., Bradley, A. J., & Dottorini, T. (2021). Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis. PLoS Computational Biology, 17(6), Article e1009108. https://doi.org/10.1371/journal.pcbi.1009108

Staphylococcus aureus is a serious human and animal pathogen threat exhibiting extraordinary capacity for acquiring new antibiotic resistance traits in the pathogen population worldwide. The development of fast, affordable and effective diagnostic... Read More about Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis.

Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test (2021)
Journal Article
Swinkels, J., Leach, K., Breen, J., Payne, B., White, V., Green, M., & Bradley, A. (2021). Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test. Journal of Dairy Science, Article 19258. https://doi.org/10.3168/jds.2020-19258

Selective use of antibiotic dry cow treatment can be implemented at the cow or quarter level, with the latter having the potential to further reduce antibiotic use. Our objective was to compare these 2 approaches in 6 herds in the United Kingdom in w... Read More about Randomized controlled field trial comparing quarter and cow level selective dry cow treatment using the California Mastitis Test.

Quantitative analysis of antimicrobial use on British dairy farms (2017)
Journal Article
Hyde, R. M., Remnant, J. G., Bradley, A. J., Breen, J. E., Hudson, C. D., Davies, P. L., …Green, M. J. (in press). Quantitative analysis of antimicrobial use on British dairy farms. Veterinary Record, 181(25), https://doi.org/10.1136/vr.104614

Antimicrobial resistance has been reported to represent a growing threat to both human and animal health, and concerns have been raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide a benchmark for dairy cattle... Read More about Quantitative analysis of antimicrobial use on British dairy farms.

The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms (2017)
Journal Article
Bradley, A. J., Leach, K. A., Green, M. J., Gibbons, J., Ohnstad, I. C., Black, D. H., …Breen, J. E. (in press). The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms. International Journal of Food Microbiology, https://doi.org/10.1016/j.ijfoodmicro.2017.12.022

The introduction of bedding dairy cows on recycled manure solids (RMS) in the UK led to concern by competent authorities that there could be an increased, unacceptable risk to animal and human health. A cross-sectional study was designed to evaluate... Read More about The impact of dairy cows' bedding material and its microbial content on the quality and safety of milk: a cross sectional study of UK farms.

Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows (2017)
Journal Article
Down, P., Bradley, A. J., Breen, J., & Green, M. J. (2017). Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows. Preventive Veterinary Medicine, 145, https://doi.org/10.1016/j.prevetmed.2017.07.006

The objective of this study was to use probabilistic sensitivity analysis to evaluate the cost-effectiveness of using an on-farm culture (OFC) approach to the treatment of clinical mastitis in dairy cows and compare this to a ‘standard’ treatment app... Read More about Factors affecting the cost-effectiveness of on-farm culture prior to the treatment of clinical mastitis in dairy cows.

Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds (2017)
Journal Article
Archer, S. C., Bradley, A. J., Cooper, S., Davies, P., & Green, M. J. (2017). Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds. Preventive Veterinary Medicine, 144, https://doi.org/10.1016/j.prevetmed.2017.05.015

The purpose of this study was to evaluate whether the risk of Streptococcus uberis clinical mastitis at cow level could be predicted from the historical presence of specific strains of S. uberis on dairy farms. Matrix-assisted laser desorption ioniza... Read More about Prediction of Streptococcus uberis clinical mastitis risk using Matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) in dairy herds.

A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds (2016)
Journal Article
Down, P., Bradley, A., Breen, J., Browne, W., Kypraios, T., & Green, M. (2016). A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds. Preventive Veterinary Medicine, 133, 64-72. https://doi.org/10.1016/j.prevetmed.2016.09.012

Importance of the dry period with respect to mastitis control is now well established although the precise interventions that reduce the risk of acquiring intramammary infections during this time are not clearly understood. There are very few interve... Read More about A Bayesian micro-simulation to evaluate the cost-effectiveness of interventions for mastitis control during the dry period in UK dairy herds.

Prediction of intramammary infection status across the dry period from lifetime cow records (2016)
Journal Article
Henderson, A., Hudson, C., Bradley, A. J., Sherwin, V., & Green, M. J. (2016). Prediction of intramammary infection status across the dry period from lifetime cow records. Journal of Dairy Science, 99(7), https://doi.org/10.3168/jds.2015-10684

The dry period is very important for mammary gland health, with the aim not only to cure existing intramammary infections (IMI) but also to prevent new IMI. Although it is known that the dry period is an important time for optimizing udder health, th... Read More about Prediction of intramammary infection status across the dry period from lifetime cow records.

Current management practices and interventions prioritised as part of a nationwide mastitis control plan (2016)
Journal Article
Down, P., Bradley, A. J., Breen, J., Hudson, C., & Green, M. J. (2016). Current management practices and interventions prioritised as part of a nationwide mastitis control plan. Veterinary Record, 178(449), https://doi.org/10.1136/vr.103203

The objectives of this study were to report performance and management data taken from a sample of UK dairy farms that have participated in the Agriculture and Horticulture Development Board Dairy Mastitis Control Plan (DMCP) and to identify importan... Read More about Current management practices and interventions prioritised as part of a nationwide mastitis control plan.

Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission (2015)
Journal Article
Davies, P., Archer, S. C., Emes, R. D., Bradley, A. J., Leigh, J., & Green, M. J. (2016). Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission. Journal of Clinical Microbiology, 54(1), https://doi.org/10.1128/JCM.01583-15

Multi Locus Sequence Typing was successfully completed on 494 isolates of S. uberis from clinical mastitis cases in a study of 52 commercial dairy herds over a 12 month period. In total, 195 sequence types (STs) were identified. S. uberis mastitis ca... Read More about Molecular epidemiology of Streptococcus uberis clinical mastitis in dairy herds: strain heterogeneity and transmission.

Recycling manure as cow bedding: potential benefits and risks for UK dairy farms (2015)
Journal Article
Lech, K. A., Archer, S. C., Breen, J. E., Green, M. J., Ohnstad, I. C., Tuer, S., & Bradley, A. J. (in press). Recycling manure as cow bedding: potential benefits and risks for UK dairy farms. Veterinary Journal, 206(2), https://doi.org/10.1016/j.tvjl.2015.08.013

Material obtained from physical separation of slurry (recycled manure solids; RMS) has been used as bedding for dairy cows in dry climates in the US since the 1970s. Relatively recently, the technical ability to produce drier material has led to adop... Read More about Recycling manure as cow bedding: potential benefits and risks for UK dairy farms.

An investigation of the dynamics of intramammary infections acquired during the dry period on European dairy farms (2015)
Journal Article
Bradley, A. J., De Vliegher, S., Green, M. J., Larrosa, P., Payne, B., van de Leemput, E. S., …Goby, L. (2015). An investigation of the dynamics of intramammary infections acquired during the dry period on European dairy farms. Journal of Dairy Science, 98(9), https://doi.org/10.3168/jds.2014-8749

The dry period is acknowledged as playing a key role in mastitis epidemiology and yet surprisingly few studies have explored dry period infection dynamics in detail. The aim of this study was to investigate the dynamics of intramammary infection acro... Read More about An investigation of the dynamics of intramammary infections acquired during the dry period on European dairy farms.

Dairy herd mastitis and reproduction: using simulation to aid interpretation of results from discrete time survival analysis (2015)
Journal Article
Hudson, C. D., Bradley, A. J., Breen, J. E., & Green, M. J. (2015). Dairy herd mastitis and reproduction: using simulation to aid interpretation of results from discrete time survival analysis. Veterinary Journal, 204(1), https://doi.org/10.1016/j.tvjl.2015.01.024

Probabilistic sensitivity analysis (PSA) is a simulation-based technique for evaluating the relative importance of different inputs to a complex process model. It is commonly employed in decision analysis and for evaluation of the potential impact of... Read More about Dairy herd mastitis and reproduction: using simulation to aid interpretation of results from discrete time survival analysis.

An investigation of the efficacy of a polyvalent mastitis vaccine using different vaccination regimens under field conditions in the United Kingdom (2014)
Journal Article
Bradley, A., Breen, J., Payne, B., White, V., & Green, M. (2015). An investigation of the efficacy of a polyvalent mastitis vaccine using different vaccination regimens under field conditions in the United Kingdom. Journal of Dairy Science, 98(3), https://doi.org/10.3168/jds.2014-8332

Vaccination can play a useful role in mastitis control programs, although there is a relative dearth of large, well-controlled field efficacy studies. This paper presents the findings on the use of a commercially available vaccine (Startvac, Hipra UK... Read More about An investigation of the efficacy of a polyvalent mastitis vaccine using different vaccination regimens under field conditions in the United Kingdom.

Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis (2013)
Journal Article
Swinkels, J., Lam, T., Green, M. J., & Bradley, A. J. (2013). Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis. Veterinary Journal, 197(3), https://doi.org/10.1016/j.tvjl.2013.03.010

The effectiveness of antibiotic treatment of clinical mastitis (CM) is classically evaluated using bacteriological cure, which provides a concise and objective way of assessing efficacy but does not reflect the situation in the field where persistenc... Read More about Effect of extended cefquinome treatment on clinical persistence or recurrence of environmental clinical mastitis.

Associations between udder health and reproductive performance in United Kingdom dairy cows (2012)
Journal Article
Hudson, C., Bradley, A. J., Breen, J., & Green, M. J. (2012). Associations between udder health and reproductive performance in United Kingdom dairy cows. Journal of Dairy Science, 95(7), https://doi.org/10.3168/jds.2011-4629

The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit of data represented a 2-d period during lactation where a cow... Read More about Associations between udder health and reproductive performance in United Kingdom dairy cows.