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Quantitative analysis of antimicrobial use on British dairy farms

Hyde, Robert M.; Remnant, John G.; Bradley, Andrew J.; Breen, James E.; Hudson, Christopher D.; Davies, Peers L.; Clarke, Tom; Critchell, Yvonne; Hylands, Matthew; Linton, Emily; Wood, Erika; Green, Martin J.

Authors

Robert M. Hyde svxrh1@nottingham.ac.uk

John G. Remnant

Andrew J. Bradley

James E. Breen

Christopher D. Hudson chris.hudson@nottingham.ac.uk

Peers L. Davies

Tom Clarke

Yvonne Critchell

Matthew Hylands

Emily Linton

Erika Wood

Martin J. Green



Abstract

Antimicrobial resistance has been reported to represent a growing threat to both human and animal health, and concerns have been raised around levels of antimicrobial usage (AMU) within the livestock industry. To provide a benchmark for dairy cattle AMU and identify factors associated with high AMU, data from a convenience sample of 358 dairy farms were analysed using both mass-based and dose-based metrics following standard methodologies proposed by the European Surveillance of Veterinary Antimicrobial Consumption project. Metrics calculated were mass (mg) of antimicrobial active ingredient per population correction unit (mg/PCU), defined daily doses (DDDvet) and defined course doses (DCDvet). AMU on dairy farms ranged from 0.36 to 97.79 mg/PCU, with a median and mean of 15.97 and 20.62 mg/PCU, respectively. Dose-based analysis ranged from 0.05 to 20.29 DDDvet, with a median and mean of 4.03 and 4.60 DDDvet, respectively. Multivariable analysis highlighted that usage of antibiotics via oral and footbath routes increased the odds of a farm being in the top quartile (>27.9 mg/PCU) of antimicrobial users. While dairy cattle farm AMU appeared to be lower than UK livestock average, there were a selection of outlying farms with extremely high AMU, with the top 25 per cent of farms contributing greater than 50 per cent of AMU by mass. Identification of these high use farms may enable targeted AMU reduction strategies and facilitate a significant reduction in overall dairy cattle AMU.

Journal Article Type Article
Journal Veterinary Record
Print ISSN 0042-4900
Electronic ISSN 2042-7670
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 181
Issue 25
APA6 Citation Hyde, R. M., Remnant, J. G., Bradley, A. J., Breen, J. E., Hudson, C. D., Davies, P. L., …Green, M. J. (in press). Quantitative analysis of antimicrobial use on British dairy farms. Veterinary Record, 181(25), doi:10.1136/vr.104614
DOI https://doi.org/10.1136/vr.104614
Publisher URL http://veterinaryrecord.bmj.com/content/181/25/683
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information © British Veterinary Association

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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