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Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved (2021)
Journal Article
Mohd Jaafar, F., Monsion, B., Belhouchet, M., Mertens, P. P. C., & Attoui, H. (2021). Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved. Viruses, 13(8), Article 1437. https://doi.org/10.3390/v13081437

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect... Read More about Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

Detecting Dairy Cow Behavior Using Vision Technology (2021)
Journal Article
McDonagh, J., Tzimiropoulos, G., Slinger, K. R., Huggett, Z. J., Down, P. M., & Bell, M. J. (2021). Detecting Dairy Cow Behavior Using Vision Technology. Agriculture, 11(7), Article 675. https://doi.org/10.3390/agriculture11070675

The aim of this study was to investigate using existing image recognition techniques to predict the behavior of dairy cows. A total of 46 individual dairy cows were monitored continuously under 24 h video surveillance prior to calving. The video was... Read More about Detecting Dairy Cow Behavior Using Vision Technology.

A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids (2021)
Journal Article
Olufemi, O. T., Barba, M., & Daly, J. M. (2021). A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids. Pathogens, 10(7), Article 899. https://doi.org/10.3390/pathogens10070899

West Nile virus (WNV) is an emerging and re-emerging zoonotic flavivirus first identified in and endemic to Africa. The virus is transmitted between birds by biting mosquitoes, with equids and humans being incidental hosts. The majority of infected i... Read More about A Scoping Review of West Nile Virus Seroprevalence Studies among African Equids.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies (2021)
Journal Article
Scaife, P. J., Simpson, A., Kurlak, L. O., Briggs, L. V., Gardner, D. S., Pipkin, F. B., …Mistry, H. D. (2021). Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies. International Journal of Molecular Sciences, 22(14), Article 7295. https://doi.org/10.3390/ijms22147295

Up to 11% of pregnancies extend to post-term with adverse obstetric events linked to pregnancies over 42 weeks. Oxidative stress and senescence (cells stop growing and dividing by irreversibly arresting their cell cycle and gradually ageing) can resu... Read More about Increased Placental Cell Senescence and Oxidative Stress in Women with Pre-Eclampsia and Normotensive Post-Term Pregnancies.

Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution (2021)
Journal Article
Vaud, S., Pearcy, N., Hanževački, M., Van Hagen, A. M., Abdelrazig, S., Safo, L., …Bryan, S. J. (2021). Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution. Metabolic Engineering, 67, 308-320. https://doi.org/10.1016/j.ymben.2021.07.001

Ethylene is a small hydrocarbon gas widely used in the chemical industry. Annual worldwide production currently exceeds 150 million tons, producing considerable amounts of CO2 contributing to climate change. The need for a sustainable alternative is... Read More about Engineering improved ethylene production: Leveraging systems Biology and adaptive laboratory evolution.

A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions (2021)
Journal Article
Blanchard, A. M., Staley, C. E., Shaw, L., Wattegedera, S. R., Baumbach, C., Michler, J. K., …Tötemeyer, S. (2021). A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions. Infection and Immunity, 89(10), Article e00270-21. https://doi.org/10.1128/iai.00270-21

Footrot is a polymicrobial infectious disease in sheep causing severe lameness, leading to one of the industry’s largest welfare problems. The complex etiology of footrot makes in situ or in vitro investigations difficult. Computational methods offer... Read More about A Trifecta of New Insights into Ovine Footrot for Infection Drivers, Immune Response, and Host-Pathogen Interactions.

Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms (2021)
Journal Article
Pearcy, N., Hu, Y., Baker, M., Maciel-Guerra, A., Xue, N., Wang, W., …Dottorini, T. (2021). Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms. mSystems, 6(4), Article e00913-20. https://doi.org/10.1128/mSystems.00913-20

Antimicrobial resistance (AMR) is becoming one of the largest threats to public health worldwide, with the opportunistic pathogen Escherichia coli playing a major role in the AMR global health crisis. Unravelling the complex interplay between drug re... Read More about Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms.

Owners' Knowledge and Approaches to Colic in Working Equids in Honduras (2021)
Journal Article
Wild, I., Freeman, S., Robles, D., Matamoros, D., Ortiz, M., Rodriguez, J., & Burford, J. (2021). Owners' Knowledge and Approaches to Colic in Working Equids in Honduras. Animals, 11(7), Article 2087. https://doi.org/10.3390/ani11072087

In Honduras, many families are reliant on working equids in their daily life. The aim of this study was to evaluate knowledge about, and approaches to colic used by owners of working equids in Choluteca, Honduras using a phenomenological approach. Se... Read More about Owners' Knowledge and Approaches to Colic in Working Equids in Honduras.

Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow (2021)
Journal Article
Zheng, W. B., Zou, Y., Liu, Q., Hu, M. H., Elsheikha, H. M., & Zhu, X. Q. (2021). Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow. Frontiers in Cell and Developmental Biology, 9, Article 688128. https://doi.org/10.3389/fcell.2021.688128

Bone marrow is the main hematopoietic organ that produces red blood cells, granulocytes, monocyte/macrophages, megakaryocytes, lymphocytes, and myeloid dendritic cells. Many of these cells play roles in the pathogenesis of Toxocara canis infection, a... Read More about Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow.

Root angle in maize influences nitrogen capture and is regulated by calcineurin B-like protein (CBL)-interacting serine/threonine-protein kinase 15 (ZmCIPK15) (2021)
Journal Article
Schneider, H. M., Lor, V. S. N., Hanlon, M. T., Perkins, A., Kaeppler, S. M., Borkar, A. N., …Lynch, J. P. (2022). Root angle in maize influences nitrogen capture and is regulated by calcineurin B-like protein (CBL)-interacting serine/threonine-protein kinase 15 (ZmCIPK15). Plant, Cell and Environment, 45(3), 837-853. https://doi.org/10.1111/pce.14135

Crops with reduced nutrient and water requirements are urgently needed in global agriculture. Root growth angle plays an important role in nutrient and water acquisition. A maize diversity panel of 481 genotypes was screened for variation in root ang... Read More about Root angle in maize influences nitrogen capture and is regulated by calcineurin B-like protein (CBL)-interacting serine/threonine-protein kinase 15 (ZmCIPK15).

Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis (2021)
Journal Article
Esener, N., Guerra, A. M., Giebel, K., Lea, D., Green, M. J., Bradley, A. J., & Dottorini, T. (2021). Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis. PLoS Computational Biology, 17(6), Article e1009108. https://doi.org/10.1371/journal.pcbi.1009108

Staphylococcus aureus is a serious human and animal pathogen threat exhibiting extraordinary capacity for acquiring new antibiotic resistance traits in the pathogen population worldwide. The development of fast, affordable and effective diagnostic... Read More about Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis.

BSE can propagate in sheep co-infected or pre-infected with scrapie (2021)
Journal Article
Chong, A., Foster, J. D., Goldmann, W., Gonzalez, L., Jeffrey, M., O'Connor, M. J., …Hunter, N. (2021). BSE can propagate in sheep co-infected or pre-infected with scrapie. Scientific Reports, 11, Article 11931. https://doi.org/10.1038/s41598-021-91397-8

To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneously into sh... Read More about BSE can propagate in sheep co-infected or pre-infected with scrapie.

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames (2021)
Journal Article
Blythe, M. J., Kocer, A., Rubio-Roldan, A., Giles, T., Abakir, A., Ialy-Radio, C., …Ruzov, A. (2021). LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames. Communications Biology, 4, Article 691. https://doi.org/10.1038/s42003-021-02217-8

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv... Read More about LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.

Practical data skills for the farm animal vet (2021)
Journal Article
Hyde, R., Green, M., Hudson, C., & Remnant, J. (2021). Practical data skills for the farm animal vet. In Practice, 43(5), 257-268. https://doi.org/10.1002/inpr.53

Background: While farm animal veterinarians receive extensive training in the diagnosis and treatment of individual animals, population medicine or ‘herd health’ has also become commonplace in modern production animal veterinary medicine. Clinicians... Read More about Practical data skills for the farm animal vet.

Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses (2021)
Journal Article
Cong, W., & Elsheikha, H. M. (2021). Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses. Yale Journal of Biology and Medicine, 94(2), 297-309

Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic z... Read More about Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses.

Multiple model triangulation to identify factors associated with lameness in British sheep flocks (2021)
Journal Article
Lewis, K., Green, M., Witt, J., & Green, L. (2021). Multiple model triangulation to identify factors associated with lameness in British sheep flocks. Preventive Veterinary Medicine, 193, Article 105395. https://doi.org/10.1016/j.prevetmed.2021.105395

Identification of factors associated with an outcome can be challenging when the number of explanatory variables is large in relation to the number of observations. Multiple model triangulation, where results from several model types are combined, im... Read More about Multiple model triangulation to identify factors associated with lameness in British sheep flocks.

The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise (2021)
Journal Article
Ebanks, B., Ingram, T. L., Katyal, G., Ingram, J. R., Moisoi, N., & Chakrabarti, L. (2021). The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise. Aging, 13(11), 14709-14728. https://doi.org/10.18632/aging.203128

One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may e... Read More about The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise.