All Outputs (1382)

Lessons from working across fields to develop a framework for informed choices (2022)
Journal Article
Stewart, R., Aronson, J. K., Barends, E., Boruch, R., Brennan, M., Chislett, J., …Vale, L. (2022). Lessons from working across fields to develop a framework for informed choices. Research for All, 6(1), https://doi.org/10.14324/rfa.06.1.05

In late 2018, Iain Chalmers, Andy Oxman and others from the Informed Health Choices team convened a cross-field forum to develop a generic framework of key concepts for thinking critically about claims, research and choices about interventions, with... Read More about Lessons from working across fields to develop a framework for informed choices.

Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry (2022)
Journal Article
Sach, F., Fields, L., Chenery, S., Yon, L., Henley, M. D., Buss, P., …Watts, M. J. (2023). Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry. Environmental Geochemistry and Health, 45(4), 1153-1164. https://doi.org/10.1007/s10653-022-01207-x

This paper evaluated analytical methods used to generate time-series data from elephant tail hairs, which can be used to reflect changing exposure to environmental geochemistry. Elephant tail hairs were analysed by three methods sequentially, each pr... Read More about Method development to characterise elephant tail hairs by LA-ICP-MS to reflect changes in elemental chemistry.

Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer (2022)
Journal Article
Kariri, Y., Toss, M. S., Alsaleem, M., Elsharawy, K. A., Joseph, C., Mongan, N. P., …Rakha, E. A. (2022). Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer. Breast Cancer Research and Treatment, 192(3), 529-539. https://doi.org/10.1007/s10549-022-06531-5

Background The Ubiquitin-conjugating enzyme 2C (UBE2C) is essential for the ubiquitin–proteasome system and is involved in cancer cell migration and apoptosis. This study aimed to determine the prognostic value of UBE2C in invasive breast cancer (BC... Read More about Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer.

The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis (2022)
Journal Article
Hyde, R. M., Green, M. J., Hudson, C., & Down, P. M. (2022). The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis. Journal of Dairy Science, 105(4), 3430-3439. https://doi.org/10.3168/jds.2021-21199

Neonatal calves are relatively susceptible to heat loss, and previous research suggests that reduced environmental temperatures are associated with reduced average daily gain (ADG) during the preweaning phase. Current methods of mitigating negative e... Read More about The effect of environmental temperature on average daily gain in preweaned calves: A randomized controlled trial and Bayesian analysis.

A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries (2022)
Journal Article
Tsoumpeli, M. T., Gray, A., Parsons, A. L., Spiliotopoulos, A., Owen, J. P., Bishop, K., …Gough, K. C. (2022). A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries. Molecular Biotechnology, 64, 791-803. https://doi.org/10.1007/s12033-021-00442-4

Phage display technology utilises peptide and antibody libraries with very high diversities to select ligands with specific binding properties. The production of such libraries can be labour intensive and technically challenging and whilst there are... Read More about A Simple Whole-Plasmid PCR Method to Construct High-Diversity Synthetic Phage Display Libraries.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., …Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Top 5 Tips for Reading a Veterinary Scientific Study (2022)
Journal Article
Arlt, S. P., & Brennan, M. L. (2022). Top 5 Tips for Reading a Veterinary Scientific Study. Clinician's brief,

Results from scientific research can help provide optimal care. Daily decisions should lead to effective diagnostic procedures and therapeutic interventions with optimal risk:benefit ratios. It is therefore important to be able to select and evaluate... Read More about Top 5 Tips for Reading a Veterinary Scientific Study.

Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching (2022)
Book Chapter
Pinel, G. D., Horder, J. L., King, J. R., McIntyre, A., Mongan, N. P., López, G. G., & Benest, A. V. (2022). Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching. In A. V. Benest (Ed.), Angiogenesis: Methods and Protocol (369-426). Springer. https://doi.org/10.1007/978-1-0716-2059-5_29

RNA-seq is a common approach used to explore gene expression data between experimental conditions or cell types and ultimately leads to information that can shed light on the biological processes involved and inform further hypotheses. While the prot... Read More about Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching.

Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea (2022)
Journal Article
Prosser, N. S., Green, M. J., Ferguson, E., Tildesley, M. J., Hill, E. M., Keeling, M. J., & Kaler, J. (2022). Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea. Journal of Dairy Science, 105(4), 3559-3573. https://doi.org/10.3168/jds.2021-21386

Bovine viral diarrhea (BVD) is endemic in the United Kingdom and causes major economic losses. Control is largely voluntary for individual farmers and is likely to be influenced by psychosocial factors, such as altruism, trust, and psychological prox... Read More about Cattle farmer psychosocial profiles and their association with control strategies for bovine viral diarrhea.

Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China (2022)
Journal Article
Wang, W., Hu, Y., Baker, M., Dottorini, T., Li, H., Dong, Y., …Li, F. (2022). Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China. Journal of Antimicrobial Chemotherapy, 77(4), 903-909. https://doi.org/10.1093/jac/dkab500

Background Staphylococcal cassette chromosome mec (SCCmec) elements are highly diverse and have been classified into 14 types. Novel SCCmec variants have been frequently detected from humans and animals but rarely from food. Objectives To charac... Read More about Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China.

Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search (2022)
Journal Article
Fairbanks, E. L., Brennan, M. L., Mertens, P. P. C., Tildesley, M. J., & Daly, J. M. (2022). Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search. Transboundary and Emerging Diseases, 69(4), e671-e681. https://doi.org/10.1111/tbed.14420

African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about... Read More about Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.

Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica (2022)
Journal Article
Shakirova, V., Khaertynova, I., Markelova, M., Tarlinton, R., Behnke, J., Martynova, E., …Khaiboullina, S. (2022). Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica. BioMed Research International, 2022, Article 4685288. https://doi.org/10.1155/2022/4685288

Nephropathia epidemica (NE) is a zoonotic disease caused by hantaviruses transmitted from rodents, endemic in the Republic of Tatarstan, Russia. The disease presents clinically with mild, moderate, and severe forms, and time-dependent febrile, oligur... Read More about Serum Cytokine Alterations Associated with Age of Patients with Nephropathia Epidemica.

Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle (2022)
Journal Article
Wang, S. S., Zhou, C. X., Elsheikha, H. M., He, J. J., Zou, F. C., Zheng, W. B., …Zhao, G. H. (2022). Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle. Parasites and Vectors, 15, Article 22. https://doi.org/10.1186/s13071-021-05140-3

Background: Long non-coding RNAs (lncRNAs) are important regulators of various biological and pathological processes, in particular the inflammatory response by modulating the transcriptional control of inflammatory genes. However, the role of lncRNA... Read More about Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle.

Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System (2022)
Journal Article
Liang, Q. L., Nie, L. B., Li, T. T., Elsheikha, H. M., Sun, L. X., Zhang, Z. W., …Wang, J. L. (2022). Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System. Frontiers in Cell and Developmental Biology, 9, Article 738794. https://doi.org/10.3389/fcell.2021.738794

Protein serine/threonine phosphatases (PSPs), found in various plants and protozoa, are involved in the regulation of various biological processes. However, very little is known about the role of PSPs in the pathogenicity of the apicomplexan protozoa... Read More about Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System.

Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia (2022)
Journal Article
Mukhamedshina, Y. O., Fayzullina, R. A., Nigmatullina, I. A., Rutland, C. S., & Vasina, V. V. (2022). Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia. BMC Medical Education, 22, Article 29. https://doi.org/10.1186/s12909-021-03095-8

Background: Autism spectrum disorder (ASD) is a complex developmental range of conditions that involves difficulties with social interaction and restricted/repetitive behaviors. Unfortunately, health care providers often experience difficulties in di... Read More about Health care providers’ awareness on medical management of children with autism spectrum disorder: cross-sectional study in Russia.

Discovery Of A Bone In Chimpanzee Hearts (2022)
Journal Article
Sturrock, C. J., Stanford, K., Moittie, S., Baiker, K., Redrobe, S., & Rutland, C. S. (2022). Discovery Of A Bone In Chimpanzee Hearts. Frontiers for Young Minds, 9, Article 592105. https://doi.org/10.3389/frym.2021.592105

The os cordis (heart bone) is a rare bone found only in a few animals in the world. We discovered an os cordis in some chimpanzees. The os cordis was found in males and females, and in young and old animals. It was not present in chimps with healthy... Read More about Discovery Of A Bone In Chimpanzee Hearts.

Mineral and vitamin supplementation on sheep farms: 
a survey of practices and farmer knowledge (2022)
Journal Article
Hession, D. V., Loughrey, J., Kendall, N. R., Hanrahan, K., & Keady, T. W. J. (2022). Mineral and vitamin supplementation on sheep farms: 
a survey of practices and farmer knowledge. Translational Animal Science, 6(1), Article txac026. https://doi.org/10.1093/tas/txac026

Mineral and vitamin (MV) supplementation is a routine management practice in many pasture-based systems of prime lamb production. The aim of the current study was to establish the MV supplementation practices on Irish sheep farms and farmer's knowled... Read More about Mineral and vitamin supplementation on sheep farms: 
a survey of practices and farmer knowledge.

Preventive hoof trimming in dairy cattle: Determining current practices and identifying future research areas (2022)
Journal Article
Pedersen, S. I., Huxley, J. N., Hudson, C. D., Green, M. J., & Bell, N. J. (2022). Preventive hoof trimming in dairy cattle: Determining current practices and identifying future research areas. Veterinary Record, https://doi.org/10.1002/vetr.1267

Background: The extent to which preventive hoof trimming is implemented on Great Britain's (GB) dairy farms is unknown. The aims of this study were to determine common practices and capture producers’ input on key areas that require further research.... Read More about Preventive hoof trimming in dairy cattle: Determining current practices and identifying future research areas.

The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions (2021)
Journal Article
Baichurina, I., Valiullin, V., James, V., Rizvanov, A., & Mukhamedshina, Y. (2021). The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions. International Journal of Molecular Sciences, 23(1), Article 114. https://doi.org/10.3390/ijms23010114

Despite extensive research on neurological disorders, unanswered questions remain regarding the molecular mechanisms underpinning the course of these diseases, and the search continues for effective biomarkers for early diagnosis, prognosis, or thera... Read More about The Study of Cerebrospinal Fluid microRNAs in Spinal Cord Injury and Neurodegenerative Diseases: Methodological Problems and Possible Solutions.

FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer (2021)
Journal Article
Larsson, P. F., Karlsson, R., Sarwar, M., Miftakhova, R., Wang, T., Syed Khaja, A. S., …Persson, J. L. (2022). FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer. Molecular Oncology, https://doi.org/10.1002/1878-0261.13166

Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of FcγRIIIa in... Read More about FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer.