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Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census (2012)
Journal Article
Stavisky, J., Brennan, M. L., Downes, M. J., & Dean, R. S. (2012). Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census. BMC Veterinary Research, 8, Article 163. https://doi.org/10.1186/1746-6148-8-163

Background The population of dogs and cats passing through rescue shelters may be subject to compromised welfare and increased susceptibility to disease. Little information exists to describe this population, its dynamics and associated management... Read More about Demographics and economic burden of un-owned cats and dogs in the UK: results of a 2010 census.

Geriatric screening in first opinion practice: results from 45 dogs (2012)
Journal Article
Davies, M. (2012). Geriatric screening in first opinion practice: results from 45 dogs. Journal of Small Animal Practice, 53(9), https://doi.org/10.1111/j.1748-5827.2012.01247.x

Objectives To evaluate and report the results of screening geriatric dogs in a first opinion practice. Methods A prospective health screen of dogs over nine-years-old involving history taking, physical examination and urinalysis. Results At leas... Read More about Geriatric screening in first opinion practice: results from 45 dogs.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article
Nelli, R. K., Dunham, S. P., Kuchipudi, S. V., White, G. A., Baquero-Perez, B., Pengxiang, C., …Chang, K. (2012). Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release. Journal of Virology, 86(17), https://doi.org/10.1128/JVI.00244-12

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.

Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates (2012)
Journal Article
Redshaw, Z., & Loughna, P. T. (2012). Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates. Differentiation, 84(2), https://doi.org/10.1016/j.diff.2012.06.001

The physiological oxygen concentration of many tissues is far lower than that in which cells are typically cultured in vitro and this may inadvertently influence the proliferation and differentiation potential of many cell types. Muscle derived stem... Read More about Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates.

Altered placental expression of kisspeptin and its receptor in pre-eclampsia (2012)
Journal Article
Cartwright, J. E., & Williams, P. J. (2012). Altered placental expression of kisspeptin and its receptor in pre-eclampsia. Journal of Endocrinology, 214(1), https://doi.org/10.1530/JOE-12-0091

Kisspeptin, originally identified as metastatin, important in preventing cancer metastasis, has more recently been shown to be important in pregnancy. Roles indicated for kisspeptin in pregnancy include regulating trophoblast invasion and migration d... Read More about Altered placental expression of kisspeptin and its receptor in pre-eclampsia.

Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle (2012)
Journal Article
Egan, S. A., Ward, P. N., Watson, M., Field, T. R., & Leigh, J. A. (in press). Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle. Microbiology, 158, https://doi.org/10.1099/mic.0.055863-0

The regulation and control of gene expression in response to differing environmental stimuli is crucial for successful pathogen adaptation and persistence. The regulatory gene vru of Streptococcus uberis encodes a stand-alone response regulator with... Read More about Vru (Sub0144) controls expression of proven and putative virulence determinants and alters the ability of Streptococcus uberis to cause disease in dairy cattle.

On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry (2012)
Journal Article
Pang, V., Counillon, L., Lagadic-Gossmann, D., Poet, M., Lacroix, J., Sergent, O., …Rauch, C. (2012). On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry. Cell Biochemistry and Biophysics, 63(1), https://doi.org/10.1007/s12013-012-9340-7

The sodium-proton exchanger 1 (NHE-1) is a membrane transporter that exchanges Na+ for H+ ion across the membrane of eukaryotic cells. It is cooperatively activated by intracellular protons, and this allosteric regulation is modulated by the biophysi... Read More about On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry.

Opinions and practices of veterinarians and dairy farmers towards herd health management in the UK (2012)
Journal Article
Hall, J., & Wapenaar, W. (2012). Opinions and practices of veterinarians and dairy farmers towards herd health management in the UK. Veterinary Record, 170(17), https://doi.org/10.1136/vr.100318

The objective was to compare farm veterinary surgeons’ and dairy farmers’ opinions on herd health plans and herd health and production management with the aim of discovering and better understanding the differences. Two comparable questionnaires, o... Read More about Opinions and practices of veterinarians and dairy farmers towards herd health management in the UK.

Na+, K+-ATPase subunit composition in a human chondrocyte cell line; evidence for the presence of ?1, ?3, ?1, ?2 and ?3 isoforms (2012)
Journal Article
Mobasheri, A., Trujillo, E., Arteaga, M., & Martin-Vasallo, P. (2012). Na+, K+-ATPase subunit composition in a human chondrocyte cell line; evidence for the presence of ?1, ?3, ?1, ?2 and ?3 isoforms. International Journal of Molecular Sciences, 13(4), https://doi.org/10.3390/ijms13045019

Membrane transport systems participate in fundamental activities such as cell cycle control, proliferation, survival, volume regulation, pH maintenance and regulation of extracellular matrix synthesis. Multiple isoforms of Na+, K+-ATPase are expresse... Read More about Na+, K+-ATPase subunit composition in a human chondrocyte cell line; evidence for the presence of ?1, ?3, ?1, ?2 and ?3 isoforms.

Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes (2012)
Journal Article
Hdud, I. M., El-Shafei, A. A., Loughna, P., Barrett-Jolley, R., & Mobasheri, A. (2012). Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes. International Journal of Molecular Sciences, 13(4), https://doi.org/10.3390/ijms13044433

Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV) subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective c... Read More about Expression of transient receptor potential vanilloid (TRPV) channels in different passages of articular chondrocytes.

Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health (2012)
Journal Article
Mobasheri, A., Henrotin, Y., Biesalski, H., & Shakibaei, M. (2012). Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. International Journal of Molecular Sciences, 13(4), https://doi.org/10.3390/ijms13044202

Interleukin 1? (IL-1?) and tumor necrosis factor ? (TNF-?) are key cytokines that drive the production of inflammatory mediators and matrix-degrading enzymes in osteoarthritis (OA). These proinflammatory cytokines bind to their respective cell surfac... Read More about Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health.

Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1?-Induced NF-?B Activation in Canine Articular Chondrocytes (2012)
Journal Article
Shakibaei, M., Allaway, D., Nebrich, S., & Mobasheri, A. (2012). Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1?-Induced NF-?B Activation in Canine Articular Chondrocytes. Evidence-Based Complementary and Alternative Medicine, 2012, Article 509383. https://doi.org/10.1155/2012/509383

The aim of this study was to characterize the anti-inflammatory mode of action of botanical extracts from rosehip (Rosa canina), willow bark (Salix alba), and nettle leaf (Urtica dioica) in an in vitro model of primary canine articular chondrocytes.... Read More about Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1?-Induced NF-?B Activation in Canine Articular Chondrocytes.

A semi-parametric model for lactation curves: development and application (2012)
Journal Article
Madouasse, A., Browne, W., Huxley, J., Toni, F., & Green, M. (2012). A semi-parametric model for lactation curves: development and application. Preventive Veterinary Medicine, 105(1-2), https://doi.org/10.1016/j.prevetmed.2012.02.009

We propose a semi-parametric model for lactation curves that, along with stage of lactation, accounts for day of the year at milk recording and stage of gestation. Lactation is described as having 3 different phases defined by 2 change points of whic... Read More about A semi-parametric model for lactation curves: development and application.

Associations between udder health and reproductive performance in United Kingdom dairy cows (2012)
Journal Article
Hudson, C., Bradley, A. J., Breen, J., & Green, M. J. (2012). Associations between udder health and reproductive performance in United Kingdom dairy cows. Journal of Dairy Science, 95(7), https://doi.org/10.3168/jds.2011-4629

The objective of this research was to evaluate the relationship between udder health and reproductive performance in UK dairy cows. Data from 80 herds were restructured such that each unit of data represented a 2-d period during lactation where a cow... Read More about Associations between udder health and reproductive performance in United Kingdom dairy cows.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity (2012)
Journal Article
Foxler, D. E., Bridge, K. S., James, V., Webb, T. M., Mee, M., Wong, S. C. K., …Sharp, T. V. (2012). The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nature Cell Biology, 14(2), 201-208. https://doi.org/10.1038/ncb2424

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension1,2. In high O2 tension (normoxia) the PHDs hydroxylate t... Read More about The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing (2012)
Journal Article
Brown, K., Moreton, J., Malla, S., Aboobaker, A. A., Emes, R. D., & Tarlinton, R. E. (2012). Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing. Virology, 433(1), https://doi.org/10.1016/j.virol.2012.07.010

The recently released draft horse genome is incompletely characterised in terms of its repetitive element pro?le. This paper presents characterisation of the endogenous retrovirus (ERVs) of the horse genome based on a data-mining strategy using mur... Read More about Characterisation of retroviruses in the horse genome and their transcriptional activity via transcriptome sequencing.

Role of the rumen in copper and thiomolybdate absorption (2011)
Journal Article
Gould, L., & Kendall, N. R. (2011). Role of the rumen in copper and thiomolybdate absorption. Nutrition Research Reviews, 24(2), https://doi.org/10.1017/S0954422411000059

The rumen is the site of significant interactions between Cu, S and Mo. It also shows reactions between Cu, S and Fe. The interaction between Mo and S results in the formation of thiomolybdates, which in the absence of adequate quantities of rumen Cu... Read More about Role of the rumen in copper and thiomolybdate absorption.

Measurement and error of hoof horn growth rate in sheep (2011)
Journal Article
Shelton, J., Usherwood, N., Wapenaar, W., Brennan, M. L., & Green, L. (2012). Measurement and error of hoof horn growth rate in sheep. Journal of Agricultural Science, 150(3), https://doi.org/10.1017/S0021859611000748

Determining the rate of hoof horn growth in sheep is important for understanding the physiology and pathology of the foot and the impact of the environment and the treatment of diseased feet on foot health. It could lead to improved understanding of... Read More about Measurement and error of hoof horn growth rate in sheep.