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All Outputs (102)

Pathological findings in the pituitary glands of 201 dogs and cats (2018)
Journal Article
Polledo, L., Grinwis, G. C., Graham, P., Dunning, M., & Baiker, K. (2018). Pathological findings in the pituitary glands of 201 dogs and cats. Veterinary Pathology, 55(6), 880-888. https://doi.org/10.1177/0300985818784162

With the exception of classic functional adenomas in dogs and horses, pituitary lesions are infrequently described in the veterinary literature. Approximately 10% of pituitary glands from asymptomatic humans contain abnormalities but the equivalent p... Read More about Pathological findings in the pituitary glands of 201 dogs and cats.

Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15 (2018)
Journal Article
Liu, Q., Gao, W., Elsheikha, H. M., He, J., Li, F., Yang, W., & Zhu, X. (2018). Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15. Parasitology Research, 117(9), 2785–2793. https://doi.org/10.1007/s00436-018-5966-8

Growth and replication of the protozoan parasite Toxoplasma gondii within host cell entail the production of several effector proteins, which the parasite exploits for counteracting the host’s immune response. Despite considerable research to define... Read More about Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15.

Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective (2018)
Journal Article
Lahuerta-Marin, A., Brennan, M., Finney, G., O’Hagan, M., & Jack, C. (in press). Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective. Irish Veterinary Journal, 71(1), https://doi.org/10.1186/s13620-018-0125-1

Background: Agriculture and farming are valued contributors to local economy in Northern Ireland (NI). There is limited knowledge about farmers’ behaviours and attitudes towards disease biosecurity measures. As part of a larger project, a scenario-ba... Read More about Key actors in driving behavioural change in relation to on-farm biosecurity; a Northern Ireland perspective.

Toxocariasis: a silent threat with a progressive public health impact (2018)
Journal Article
Chen, J., Liu, Q., Liu, G., Zheng, W., Hong, S., Sugiyama, H., …Elsheikha, H. M. (in press). Toxocariasis: a silent threat with a progressive public health impact. Infectious Diseases of Poverty, 7(1), https://doi.org/10.1186/s40249-018-0437-0

Background: Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide, especially in impoverished communities. This disease is caused by infection with the larvae of Toxocara canis and... Read More about Toxocariasis: a silent threat with a progressive public health impact.

A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses (2018)
Journal Article
Tian, A., Elsheikha, H. M., Zhou, D., Wu, Y., Chen, M., Wang, M., …Zhu, X. (2018). A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses. Veterinary Parasitology, 258, https://doi.org/10.1016/j.vetpar.2018.06.004

The development of a method to rapidly diagnose Neospora caninum infection is highly desirable. Recombinase polymerase amplification (RPA), combined with lateral flow (LF) strips, is a novel approach to rapidly amplify and visualize DNA. We have deve... Read More about A novel recombinase polymerase amplification (RPA) assay for the rapid isothermal detection of Neospora caninum in aborted bovine fetuses.

A retrospective review of great ape cardiovascular disease epidemiology and pathology (2018)
Journal Article
Strong, V. J., Martin, M., Redrobe, S., White, K., & Baiker, K. (2018). A retrospective review of great ape cardiovascular disease epidemiology and pathology. International Zoo Yearbook, 52(1), 113-125. https://doi.org/10.1111/izy.12193

Cardiovascular disease is associated with significant mortality in zoo-housed great apes and yet little is know about its epidemiology and aetiopathogenesis, and therefore its diagnosis, treatment and prevention. In this retrospective study, the fre... Read More about A retrospective review of great ape cardiovascular disease epidemiology and pathology.

Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis (2018)
Journal Article
White, C., Jones, G., Baker, S., Dean, R., & Brennan, M. (2018). Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis. Veterinary Sciences, 5(2), https://doi.org/10.3390/vetsci5020054

Treatment variation in medicine may be driven by evidence gaps, clinician factors, and patient preferences. Although well-documented in human medicine, variation in clinical management is relatively unexplored in veterinary practice. Clinical vignett... Read More about Variation in the reported management of canine prolapsed nictitans gland and feline herpetic keratitis.

The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology (2018)
Journal Article
de Brot, S., Robinson, B. D., Scase, T., Grau‑Roma, L., Wilkinson, E., Boorjian, S. A., …Mongan, N. P. (2018). The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology. Oncology Letters, 16(2), https://doi.org/10.3892/ol.2018.8837

Despite the recent approval of several novel agents for patients with metastatic urothelial carcinoma (UC), survival in this setting remains poor. As such, continued investigation into novel therapeutic options remains warranted. Pre clinical develop... Read More about The dog as an animal model for bladder and urethral urothelial carcinoma: comparative epidemiology and histology.

Needle in a haystack? A comparison of eDNA metabarcoding and targeted qPCR for detection of the great crested newt (Triturus cristatus) (2018)
Journal Article
Harper, L. R., Lawson Handley, L., Hahn, C., Boonham, N., Rees, H. C., Gough, K. C., …Hänfling, B. (2018). Needle in a haystack? A comparison of eDNA metabarcoding and targeted qPCR for detection of the great crested newt (Triturus cristatus). Ecology and Evolution, 8(12), 6330-6341. https://doi.org/10.1002/ece3.4013

Environmental DNA (eDNA) analysis is a rapid, cost-effective, non-invasive biodiversity monitoring tool which utilises DNA left behind in the environment by organisms for species detection. The method is used as a species-specific survey tool for rar... Read More about Needle in a haystack? A comparison of eDNA metabarcoding and targeted qPCR for detection of the great crested newt (Triturus cristatus).

Guidelines for consistent cardiovascular post-mortem examination, sampling and reporting of lesions in European zoo-housed great apes (2018)
Journal Article
Strong, V., Sheppard, M., Redrobe, S., & Baiker, K. (2018). Guidelines for consistent cardiovascular post-mortem examination, sampling and reporting of lesions in European zoo-housed great apes. International Zoo Yearbook, 52(1), 126-136. https://doi.org/10.1111/izy.12191

Inconsistencies and inadequacies in both the approach to post-mortem examination of the heart and the subsequent reporting of findings have been blamed for a lack of progression of understanding about great ape cardiovascular disease. In order to min... Read More about Guidelines for consistent cardiovascular post-mortem examination, sampling and reporting of lesions in European zoo-housed great apes.

A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison's disease) (2018)
Journal Article
Boag, A. M., Christie, M. R., McLaughlin, K. A., Syme, H. M., Graham, P., & Catchpole, B. (in press). A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison's disease). Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.05.013

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’... Read More about A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison's disease).

Mending a broken heart—the genetics of heart disease (2018)
Journal Article
Clark, N., Alibhai, A., & Rutland, C. S. (2018). Mending a broken heart—the genetics of heart disease. Frontiers for Young Minds, 6, Article 19. https://doi.org/10.3389/frym.2018.00019

Heart disease is a major cause of health problems worldwide. There are many different types of heart disease, but one that is fairly common and can have lots of negative side effects is called cardiomyopathy. We know that humans and many mammals, inc... Read More about Mending a broken heart—the genetics of heart disease.

Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal (2018)
Journal Article
Sarkar, B., Sarkar, S., Das, M., Bhowmick, T., Koley, H., Atterbury, R., & Chakrabarti, A. (2018). Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal. Journal of Global Infectious Diseases, 10(2), https://doi.org/10.4103/jgid.jgid_37_17

Objectives: We have isolated a total of five newer cholera phages which are novel broad host range to incorporate with the existing phage typing schemes for an extended typing scheme. Materials and Methods: These newly isolated phages were well chara... Read More about Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal.

Gainfully employing descending controls in acute and chronic pain management (2018)
Journal Article
White, K., Targett, M., & Harris, J. (2018). Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237, https://doi.org/10.1016/j.tvjl.2018.05.005

Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive... Read More about Gainfully employing descending controls in acute and chronic pain management.

Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma (2018)
Journal Article
De Santo, C., Cheng, P., Beggs, A., Egan, S., Bessudo, A., & Mussai, F. (2018). Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma. Journal of Hematology and Oncology, 11, Article 68. https://doi.org/10.1186/s13045-018-0612-6

Background Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 ant... Read More about Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma.

Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life (2018)
Journal Article
Fragkoudis, R., Dixon-Ballany, C., Zagrajek, A., Kedzierski, L., & Fazakerley, J. (2018). Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life. Viruses, 10(5), Article 273. https://doi.org/10.3390/v10050273

Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthralgia, myalgia and more severely, encephalitis. In the mouse, peripheral infection with Semliki Forest virus (SFV) result... Read More about Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life.

Student perceptions of veterinary anatomy practical classes: a longitudinal study (2018)
Journal Article
Gummery, E., Cobb, K. A., Mossop, L. H., & Cobb, M. A. (2018). Student perceptions of veterinary anatomy practical classes: a longitudinal study. Journal of Veterinary Medical Education, 45(2), https://doi.org/10.3138/jvme.0816-132r1

Using cadaveric material to teach veterinary students poses many challenges. However, little research exists on the contribution of this traditional approach to student learning. This longitudinal study aimed to investigate student perceptions of cad... Read More about Student perceptions of veterinary anatomy practical classes: a longitudinal study.

Quality of life assessment in companion animals: what, why, who, when and how (2018)
Journal Article
Belshaw, Z. (in press). Quality of life assessment in companion animals: what, why, who, when and how. Companion Animal, 23(5), https://doi.org/10.12968/coan.2018.23.5.264

Quality of life is a commonly used phrase in veterinary medicine. It describes a complex evaluation that may be difficult for animals to perform, and the phrase “happiness” may be a more crude but useful approximation. Quality of life assessments sho... Read More about Quality of life assessment in companion animals: what, why, who, when and how.

Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle (2018)
Journal Article
Barker, Z., Vázquez Diosdado, J. A., Codling, E., Bell, N., Hodges, H., Croft, D., & Amory, J. (2018). Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle. Journal of Dairy Science, 101(7), https://doi.org/10.3168/jds.2016-12172

Time constraints for dairy farmers are an important factor contributing to the under-detection of lameness, resulting in delayed or missed treatment of lame cows within many commercial dairy herds. Hence, a need exists for flexible and affordable cow... Read More about Use of novel sensors combining local positioning and acceleration to measure feeding behavior differences associated with lameness in dairy cattle.