All Outputs (1324)

Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells (2023)
Journal Article
Monsion, B., Mohd Jaafar, F., Mertens, P. P., & Attoui, H. (2023). Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells. Biomolecules, 13(6), Article 878. https://doi.org/10.3390/biom13060878

At least 12 serotypes of ‘atypical’ bluetongue virus (BTV-25 to BTV-36) have been identified to date. These atypical serotypes fail to infect/replicate in Culicoides-derived cell lines and/or adult Culicoides vectors and hence can no longer be transm... Read More about Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells.

Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases (2023)
Journal Article
Martín‐Ambrosio Francés, M., Seth, M., Sharman, M., Pollard, D., Ortiz, A. L., Miller, R., …Selgas, A. G. (2023). Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases. Veterinary Medicine and Science, 9(4), 1495-1507. https://doi.org/10.1002/vms3.1091

Background: Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagn... Read More about Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases.

An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program (2023)
Journal Article
McAloon, C. G., Tratalos, J. A., O'Grady, L., Green, M. J., Gavey, L., Graham, D., …Mee, J. F. (2023). An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program. Journal of Dairy Science, 106(7), 4966-4977. https://doi.org/10.3168/jds.2022-22519

Postnatal mortality among replacement stock has a detrimental effect on the social, economic, and environmental sustainability of dairy production. Calf mortality rates vary between countries and show differences in temporal trends; most, however, ar... Read More about An observational study of ear-tagged calf mortality (1 to 100 days) on Irish dairy farms and associations between biosecurity practices and calf mortality on farms participating in a Johne's disease control program.

Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi (2023)
Journal Article
Mikolajek, H., Sanchez-Weatherby, J., Sandy, J., Gildea, R. J., Campeotto, I., Cheruvara, H., …Hough, M. A. (2023). Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi. IUCrJ, 10(4), 420-429. https://doi.org/10.1107/s2052252523003810

The utility of X-ray crystal structures determined under ambient-temperature conditions is becoming increasingly recognized. Such experiments can allow protein dynamics to be characterized and are particularly well suited to challenging protein targe... Read More about Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.

Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood (2023)
Journal Article
Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Padmanabhan, V., Lea, R., Sinclair, K. D., …Bellingham, M. (2023). Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology, 100, Article 104152. https://doi.org/10.1016/j.etap.2023.104152

Environmental chemical (EC) exposure may be impacting male reproductive health. The translationally relevant biosolids treated pasture (BTP) sheep model was used to investigate gestational low-level EC mixture exposure on the testes of F1 male offspr... Read More about Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood.

RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance (2023)
Journal Article
Stockdale, S. R., Blanchard, A. M., Nayak, A., Husain, A., Nashine, R., Dudani, H., …Monaghan, T. M. (2023). RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance. The Lancet Regional Health – Southeast Asia, 14, Article 100205. https://doi.org/10.1016/j.lansea.2023.100205

Background: The COVID-19 pandemic showcased the power of genomic sequencing to tackle the emergence and spread of infectious diseases. However, metagenomic sequencing of total microbial RNAs in wastewater has the potential to assess multiple infectio... Read More about RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance.

Herd health: approach to assessing fertility data quality (2023)
Journal Article
Reynolds, J., & Hudson, C. (2023). Herd health: approach to assessing fertility data quality. In Practice, 45(4), 222-230. https://doi.org/10.1002/inpr.311

Background: Farm animal veterinarians are increasingly using routinely collected farm data to assess performance and enable implementation of preventive management changes on farm. Furthermore, the significance of data collection and data management... Read More about Herd health: approach to assessing fertility data quality.

The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review (2023)
Journal Article
Reyneke, R. A., Richens, I. F., Buchanan, H., Bethan Davies, E., Sorrell, C., Ashmore, A., & Brennan, M. L. (2023). The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review. Preventive Veterinary Medicine, 216, Article 105928. https://doi.org/10.1016/j.prevetmed.2023.105928

Evidence-based practices (EBPs) provide strategies to improve the health, welfare and productivity of animal species. However, ensuring implementation and uptake into routine practice of these EBPs is often challenging. In human health research, one... Read More about The use of theories, models, and frameworks to inform the uptake of evidence-based practices in veterinary medicine - a scoping review.

Targeting DNA damage repair precision medicine strategies in cancer (2023)
Journal Article
Brownlie, J., Kulkarni, S., Algethami, M., Jeyapalan, J. N., Mongan, N. P., Rakha, E. A., & Madhusudan, S. (2023). Targeting DNA damage repair precision medicine strategies in cancer. Current Opinion in Pharmacology, 70, Article 102381. https://doi.org/10.1016/j.coph.2023.102381

DNA repair targeted therapeutics is a promising precision medicine strategy in cancer. The development and clinical use of PARP inhibitors has transformed lives for many patients with BRCA germline deficient breast and ovarian cancer as well as plati... Read More about Targeting DNA damage repair precision medicine strategies in cancer.

Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II (2023)
Journal Article
Foster, T., & Khaiboullina, S. (2023). Editorial: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II. Frontiers in Microbiology, 14, Article 1193841. https://doi.org/10.3389/fmicb.2023.1193841

Editorial on the Research Topic: Community series - innovative approaches in diagnosis of emerging/re-emerging infectious diseases, volume II

Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli (2023)
Journal Article
Nicolas, M., Trotereau, A., Culot, A., Moodley, A., Atterbury, R., Wagemans, J., …Schouler, C. (2023). Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli. Microbiology Spectrum, 11(3), Article e04296-22. https://doi.org/10.1128/spectrum.04296-22

The increase in antibiotic-resistant avian-pathogenic Escherichia coli (APEC), the causative agent of colibacillosis in poultry, warrants urgent research and the development of alternative therapies. This study describes the isolation and characteriz... Read More about Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli.

Temporal trends in equine sperm progressive motility: a systematic review and meta-regression (2023)
Journal Article
Harris, I. T., Maddock, C., Farnworth, M., Nankervis, K., Perrett, J., Pyatt, A. Z., & Blanchard, R. N. (2023). Temporal trends in equine sperm progressive motility: a systematic review and meta-regression. Reproduction, 165(6), M1–M10. https://doi.org/10.1530/REP-22-0490

In brief: Adverse trends in reproductive function are a concern in humans, companion, livestock, and wildlife species. This study indicates that equine populations are at risk of a comparable decline in sperm progressive motility. Abstract: There is... Read More about Temporal trends in equine sperm progressive motility: a systematic review and meta-regression.

The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii (2023)
Journal Article
Li, T., Zhao, D., Liang, Q., Elsheikha, H. M., Wang, M., Sun, L., …Wang, J. (2023). The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii. The FASEB Journal, 37(6), Article e22932. https://doi.org/10.1096/fj.202201275r

Glutaredoxins (Grxs) are ubiquitous antioxidant proteins involved in many molecular processes to protect cells against oxidative damage. Here, we study the roles of Grxs in the pathogenicity of Toxoplasma gondii. We show that Grxs are localized in th... Read More about The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii.

A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development (2023)
Journal Article
Moxon, R., Freeman, S. L., Payne, R., Godfrey-Hunt, J., Corr, S., & England, G. C. W. (2023). A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development. Animals, 13(9), Article 1431. https://doi.org/10.3390/ani13091431

No previous large prospective cohort studies have been identified that have investigated the impact of the surgical neutering of bitches before or after known puberty on their growth and physical development. This study was designed to examine the da... Read More about A Prospective Cohort Study Investigating the Impact of Neutering Bitches Prepubertally or Post-Pubertally on Physical Development.

Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease (2023)
Journal Article
Grove, J. I., Lo, P. C., Shrine, N., Barwell, J., Wain, L. V., Tobin, M. D., …Aithal, G. P. (2023). Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease. JHEP Reports, 5(8), Article 100764. https://doi.org/10.1016/j.jhepr.2023.100764

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, de... Read More about Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease.

Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype (2023)
Journal Article
Attoui, H., Mohd Jaafar, F., Monsion, B., Klonjkowski, B., Reid, E., Fay, P. C., …Mertens, P. P. C. (2023). Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype. Pathogens, 12(4), Article 602. https://doi.org/10.3390/pathogens12040602

Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which... Read More about Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis (2023)
Journal Article
Peffers, M., Anderson, J., Jacobsen, S., Walters, M., Bundgaard, L., Hackle, M., & James, V. (2023). Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis. Orthopaedic Proceedings, 105-B(SUPP_8), 119-119. https://doi.org/10.1302/1358-992x.2023.8.119

Joint tissues release extracellular vesicles (EVs) that potentially sustain joint homeostasis and contribute to osteoarthritis (OA) pathogenesis. EVs are putative novel therapeutics for OA, and transport biologically active molecules (including small... Read More about Small non-coding RNA landscape of extracellular vesicles from an experimental model of equine osteoarthritis.

Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS (2023)
Journal Article
Wang, W., Yang, Y., Guo, H., Li, M. H., Chen, X. Q., Wei, X. Y., …Zhang, X. X. (2023). Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS. Microbiology Spectrum, 11(3), Article e0356422. https://doi.org/10.1128/spectrum.03564-22

Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life, kn... Read More about Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review (2023)
Journal Article
Moxon, R., Freeman, S. L., Payne, R., Corr, S., & England, G. C. W. (2023). Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review. Veterinary Record, 193(1), Article e2882. https://doi.org/10.1002/vetr.2882

Background There are contradictory findings in the literature relating to the effects of timing of neutering on bitch behaviour that make decision making regarding neutering timing difficult. Methods A scoping review was designed to identify an... Read More about Effect of neutering timing in relation to puberty on female dog behaviour—A scoping review.