All Outputs (138)

Factors affecting owners’ choice of nutritional supplements for use in dressage and eventing horses (2016)
Journal Article
Gemmill, R., Agar, C., Freeman, S., & Hollands, T. (in press). Factors affecting owners’ choice of nutritional supplements for use in dressage and eventing horses. Veterinary Record Open, 3(1), Article e000155. https://doi.org/10.1136/vetreco-2015-000155

The aim of this study was to investigate the factors affecting horse owners’ choice of nutritional supplements for dressage and eventing horses. An online questionnaire was distributed to owners/riders of dressage and/or event horses to collect data... Read More about Factors affecting owners’ choice of nutritional supplements for use in dressage and eventing horses.

Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow (2016)
Journal Article
Miftakhova, R., Hedblom, A., Semenas, J., Robinson, B. D., Simoulis, A., Malm, J., …Persson, J. L. (2016). Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. Cancer Research, 76(8), 2453-2464. https://doi.org/10.1158/0008-5472.CAN-15-2340

Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain... Read More about Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow.

Remote effects of acute kidney injury in a porcine model (2016)
Journal Article
Devonald, M. A., O’Sullivan, S. E., Gardner, D. S., De Brot, S., Dunford, L. J., Grau-Roma, L., …Devonald, M. A. J. (2016). Remote effects of acute kidney injury in a porcine model. AJP - Renal Physiology, 310(4), F259-F271. https://doi.org/10.1152/ajprenal.00389.2015

© 2016 the American Physiological Society. Acute kidney injury (AKI) is a common and serious condition with no specific treatment. An episode of AKI may affect organs distant from the kidney, further increasing the morbidity associated with AKI. The... Read More about Remote effects of acute kidney injury in a porcine model.

The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma (2016)
Journal Article
Fredholm, S., Livinov, I., Mongan, N. P., Schiele, S., Willerslev-Olsen, A., Petersen, D. L., …Ødum, N. (2016). The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma. Journal of Investigative Dermatology, 136(4), 866-869. https://doi.org/10.1016/j.jid.2015.12.033

Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis (2016)
Journal Article
Bonthala, V. S., Mayes, S., Moreton, J., Blythe, M. J., Wright, V., May, S., …Twycross, J. (2016). Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis. PLoS ONE, 11(2), Article e0148771. https://doi.org/10.1371/journal.pone.0148771

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an African legume and is a promising underutilized crop with good seed nutritional values. Low temperature stress in a number of African countries at night, such as Botswana, can effect the growth... Read More about Identification of gene modules associated with low temperatures response in Bambara groundnut by network-based analysis.

Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging (2016)
Journal Article
Naemat, A., Elsheikha, H. M., Boiter, R., & Notingher, I. (2016). Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging. Scientific Reports, 6, Article 20811. https://doi.org/10.1038/srep20811

This study investigates the temporal and spatial interchange of the aromatic amino acid phenylalanine (Phe) between human retinal pigment epithelial cell line (ARPE-19) and tachyzoites of the apicomplexan protozoan parasite Toxoplasma gondii (T. gond... Read More about Tracing amino acid exchange during host-pathogen interaction by combined stable-isotope time-resolved Raman spectral imaging.

Wooden breast lesions in broiler chickens in the UK (2016)
Journal Article
de Brot, S., Perez, S., Shivaprasad, H., Baiker, K., Polledo, L., Clark, M., & Grau-Roma, L. (2016). Wooden breast lesions in broiler chickens in the UK. Veterinary Record, 178(6), 141-141. https://doi.org/10.1136/vr.103561

A new condition causing significant economic losses due to lesions in the pectoralis major muscle of commercial broiler chickens has been recently reported in Finland. The condition has been named wooden breast and is characterized by its gross and h... Read More about Wooden breast lesions in broiler chickens in the UK.

The use of nutritional supplements in dressage and eventing horses (2016)
Journal Article
Agar, C., Gemmill, R., Hollands, T., & Freeman, S. (2016). The use of nutritional supplements in dressage and eventing horses. Veterinary Record Open, 3(1), Article e000154. https://doi.org/10.1136/vetreco-2015-000154

The aim of the study was to determine which types of nutritional supplements were used in dressage and eventing horses, and the reasons that owners used supplements. An online questionnaire was distributed through British Eventing and Dressage websit... Read More about The use of nutritional supplements in dressage and eventing horses.

Pilot study of long-term anaesthesia in broiler chickens (2016)
Journal Article
O'Kane, P. M., Connerton, I. F., & White, K. L. (2016). Pilot study of long-term anaesthesia in broiler chickens. Veterinary Anaesthesia and Analgesia, 43(1), 72-75. https://doi.org/10.1111/vaa.12305

Objective: To provide stable anaesthesia of long duration in broiler chickens in order to perform a terminal caecal ligated loop procedure. Study design: Prospective experimental study. Animals: Seven clinically healthy broiler chickens (Gallus... Read More about Pilot study of long-term anaesthesia in broiler chickens.

Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial (2016)
Journal Article
Thomas, H., Remnant, J., Bollard, N., Burrows, A., Whay, H., Bell, N., …Huxley, J. (in press). Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial. Veterinary Record, 178(5), Article 116. https://doi.org/10.1136/vr.103394

A positively controlled, randomised controlled trial (RCT) was undertaken to test recovery of cows with claw horn lesions resulting in lameness of greater than two weeks duration. Cows on seven commercial farms were mobility scored fortnightly and se... Read More about Recovery of chronically lame dairy cows following treatment for claw horn lesions: a randomised controlled trial.

Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer (2016)
Journal Article
Shafiee, M. N., Seedhouse, C., Mongan, N., Chapman, C., Deen, S., Abu, J., & Atiomo, W. (2016). Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer. Molecular and Cellular Endocrinology, 424, 94-101. https://doi.org/10.1016/j.mce.2016.01.019

BACKGROUND Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (E... Read More about Up-regulation of genes involved in the Insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link Polycystic Ovarian Syndrome and endometrial cancer.

Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry (2016)
Journal Article
Zhou, C. X., Zhou, D. H., Elsheikha, H., Zhao, Y., Suo, X., & Zhu, X. (2016). Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry. Scientific Reports, 6, https://doi.org/10.1038/srep19557

Better understanding of the molecular changes associated with disease is essential for identifying new routes to improved therapeutics and diagnostic tests. The aim of this study was to investigate the dynamic changes in the metabolic profile of mous... Read More about Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry.

Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma (2016)
Journal Article
Minton, D. R., Fu, L., Mongan, N. P., Shevchuk, M. M., Nanus, D. M., & Gudas, L. J. (2016). Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma. Clinical Cancer Research, 22(11), 2791-2801. https://doi.org/10.1158/1078-0432.ccr-15-1511

PURPOSE We delineated the functions of the HIF1? target NADH Dehydrogenase (Ubiquinone) 1 alpha subcomplex 4-like 2 (NDUFA4L2) in ccRCC and characterized NDUFA4L2 as a novel molecular target for ccRCC treatment. EXPERIMENTAL DESIGN We evalua... Read More about Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.

Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes (2016)
Journal Article
Moreton, J., Izquierdo, A., & Emes, R. D. (2016). Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes. Frontiers in Genetics, 6, Article 361. https://doi.org/10.3389/fgene.2015.00361

De novo assembly of a complete transcriptome without the need for a guiding reference genome is attractive, particularly where the cost and complexity of generating a eukaryote genome is prohibitive. The transcriptome should not however be seen as ju... Read More about Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes.

Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages (2016)
Journal Article
Günther, J., Czabanska, A., Bauer, I., Leigh, J. A., Holst, O., & Seyfert, H. (2016). Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages. Veterinary Research, 47(13), https://doi.org/10.1186/s13567-015-0287-8

Streptococcus uberis is frequently isolated from the mammary gland of dairy cattle. Infection with some strains can induce mild subclinical inflammation whilst others induce severe inflammation and clinical mastitis. We compared here the inflammatory... Read More about Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages.

Staphylococcus aureus enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma (2016)
Journal Article
Willerslev-Olsen, A., Krejsgaard, T., Lindahl, L. M., Litvinov, I. V., Fredholm, S., Petersen, D. L., …Odum, N. (2016). Staphylococcus aureus enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma. Blood, 127(10), 1287-1296. https://doi.org/10.1182/blood-2015-08-662353

Cutaneous T cell lymphoma (CTCL) is characterized by proliferation of malignant T cells in a chronic inflammatory environment. With disease progression, bacteria colonize the compromised skin barrier and half of CTCL patients die from infection rathe... Read More about Staphylococcus aureus enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma.

Technical considerations for the generation of novel pseudotyped viruses (2016)
Journal Article
King, B., Temperton, N., Grehan, K., Scott, S. D., Wright, E., Tarr, A. W., & Daly, J. M. (2016). Technical considerations for the generation of novel pseudotyped viruses. Future Virology, 11(1), https://doi.org/10.2217/fvl.15.106

A pseudotyped virus (PV) is a virus particle with an envelope protein originating from a different virus. The ability to dictate which envelope proteins are expressed on the surface has made pseudotyping an important tool for basic virological studie... Read More about Technical considerations for the generation of novel pseudotyped viruses.

Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH) (2016)
Journal Article
Velie, B., Blott, S., Shrestha, M., Franҫois, L., Schurink, A., Tesfayonas, Y., …Lindgren, G. (2016). Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH). PLoS ONE, 11(4), Article e0152966. https://doi.org/10.1371/journal.pone.0152966

While susceptibility to hypersensitive reactions is a common problem amongst humans and animals alike, the population structure of certain animal species and breeds provides a more advantageous route to better understanding the biology underpinning t... Read More about Using an Inbred Horse Breed in a High Density Genome-Wide Scan for Genetic Risk Factors of Insect Bite Hypersensitivity (IBH).