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Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Stem Cell Reviews and Reports, 19(6), 1856-1869. https://doi.org/10.1007/s12015-023-10544-y

Ageing impairs endothelial function and predisposes the person to ischaemic stroke (IS). Endothelial progenitor cells (EPCs) repair endothelial damage and induce post-ischaemic neovascularisation. Given the prevalence of IS in older population, this... Read More about Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach (2023)
Journal Article
Hardiman, W., Clark, M., Friel, C., Huett, A., Pérez-Cota, F., Setchfield, K., …Tassieri, M. (2023). Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach. Acta Biomaterialia, 166, 317-325. https://doi.org/10.1016/j.actbio.2023.04.039

Microrheology, the study of fluids on micron length-scales, promises to reveal insights into cellular biology, including mechanical biomarkers of disease and the interplay between biomechanics and cellular function. Here a minimally-invasive passive... Read More about Living cells as a biological analog of optical tweezers – a non-invasive microrheology approach.

Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner (2023)
Journal Article
Jackson, H. K., Mitoko, C., Linke, F., Macarthur, D., Kerr, I. D., & Coyle, B. (2023). Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner. Cancers, 15(9), Article 2601. https://doi.org/10.3390/cancers15092601

Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular vesicles termed exosomes have been shown to contribute to the establishment of a premetastatic... Read More about Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner.

Yolk Fatty Acid Content, Lipid Health Indices, and Oxidative Stability in Eggs of Slow-Growing Sasso Chickens Fed on Flaxseed Supplemented with Plant Polyphenol Extracts (2023)
Journal Article
Tadesse, D., Retta, N., Girma, M., Ndiwa, N., Dessie, T., Hanotte, O., …Maak, S. (2023). Yolk Fatty Acid Content, Lipid Health Indices, and Oxidative Stability in Eggs of Slow-Growing Sasso Chickens Fed on Flaxseed Supplemented with Plant Polyphenol Extracts. Foods, 12(9), Article 1819. https://doi.org/10.3390/foods12091819

Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study (2023)
Journal Article
Della Corte, K., Jalo, E., Kaartinen, N. E., Simpson, L., Taylor, M. A., Muirhead, R., …Brand-Miller, J. (2023). Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study. Nutrients, 15(9), Article 2083. https://doi.org/10.3390/nu15092083

Background: Dietary sugars are often linked to the development of overweight and type 2 diabetes (T2D) but inconsistencies remain. Objective: We investigated associations of added, free, and total sugars, and glycaemic index (GI) with indices of gluc... Read More about Longitudinal Associations of Dietary Sugars and Glycaemic Index with Indices of Glucose Metabolism and Body Fatness during 3-Year Weight Loss Maintenance: A PREVIEW Sub-Study.

A burst of genomic innovation at the origin of placental mammals mediated embryo implantation (2023)
Journal Article
Taylor, A. S., Tinning, H., Ovchinnikov, V., Edge, J., Smith, W., Pullinger, A. L., …O'Connell, M. J. (2023). A burst of genomic innovation at the origin of placental mammals mediated embryo implantation. Communications Biology, 6, Article 459. https://doi.org/10.1038/s42003-023-04809-y

The origin of embryo implantation in mammals ~148 million years ago was a dramatic shift in reproductive strategy, yet the molecular changes that established mammal implantation are largely unknown. Although progesterone receptor signalling predates... Read More about A burst of genomic innovation at the origin of placental mammals mediated embryo implantation.

Early‐life immune expression profiles predict later‐life health and fitness in a wild rodent (2023)
Journal Article
Wanelik, K. M., Begon, M., Bradley, J. E., Friberg, I. M., Taylor, C. H., Jackson, J. A., …Friberg, I. M. (2023). Early‐life immune expression profiles predict later‐life health and fitness in a wild rodent. Molecular Ecology, 32(13), 3471-3482. https://doi.org/10.1111/mec.16950

Individuals differ in the nature of the immune responses they produce, affecting disease susceptibility and ultimately health and fitness. These differences have been hypothesized to have an origin in events experienced early in life that then affect... Read More about Early‐life immune expression profiles predict later‐life health and fitness in a wild rodent.

Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress (2023)
Journal Article
ALNasser, M. N., AlSaadi, A. M., Whitby, A., Kim, D. H., Mellor, I. R., & Carter, W. G. (2023). Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress. Life, 13(4), Article 1019. https://doi.org/10.3390/life13041019

Aberrant accumulation of the neurotransmitter L-glutamate (L-Glu) has been implicated as a mechanism of neurodegeneration, and the release of L-Glu after stroke onset leads to a toxicity cascade that results in neuronal death. The acai berry (Euterpe... Read More about Acai Berry (Euterpe sp.) Extracts Are Neuroprotective against L-Glutamate-Induced Toxicity by Limiting Mitochondrial Dysfunction and Cellular Redox Stress.

Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration (2023)
Journal Article
Javanmardi, Y., Agrawal, A., Malandrino, A., Lasli, S., Chen, M., Shahreza, S., …Kamm, R. (2023). Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration. Advanced Science, 10(16), Article 2206554. https://doi.org/10.1002/advs.202206554

Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues. While c... Read More about Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration.

A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires (2023)
Journal Article
Begitt, A., Krause, S., Cavey, J. R., Vinkemeier, D. E., & Vinkemeier, U. (2023). A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires. Journal of Biological Chemistry, 299(5), Article 104703. https://doi.org/10.1016/j.jbc.2023.104703

The conversion of signal transducer and activator of transcription (STAT) proteins from latent to active transcription factors is central to cytokine signaling. Triggered by their signal-induced tyrosine phosphorylation, it is the assembly of a range... Read More about A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires.

No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain (2023)
Journal Article
Gonçalves, S., Hathway, G. J., Woodhams, S. G., Chapman, V., & Bast, T. (2023). No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain. Journal of Pain, 24(8), 1478-1492. https://doi.org/10.1016/j.jpain.2023.04.002

Although chronic pain states have been associated with impaired cognitive functions, including memory and cognitive flexibility, the cognitive effects of osteoarthritis (OA) pain remain to be clarified. The aim of this study was to measure cognitive... Read More about No Evidence for Cognitive Impairment in an Experimental Rat Model of Knee Osteoarthritis and Associated Chronic Pain.

Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology (2023)
Journal Article
Xu, X., Meier, F., Blount, B. A., Pretorius, I. S., Ellis, T., Paulsen, I. T., & Williams, T. C. (2023). Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology. Nature Communications, 14(1), Article 1984. https://doi.org/10.1038/s41467-023-37748-7

Naturally evolved organisms typically have large genomes that enable their survival and growth under various conditions. However, the complexity of genomes often precludes our complete understanding of them, and limits the success of biotechnological... Read More about Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology.

Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines (2023)
Journal Article
Shaw, R. H., Greenland, M., Stuart, A. S. V., Aley, P. K., Andrews, N. J., Cameron, J. C., …Snape, M. D. (2023). Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines. Journal of Infection, 86(6), 574-583. https://doi.org/10.1016/j.jinf.2023.03.027

Background: Heterologous COVID vaccine priming schedules are immunogenic and effective. This report aims to understand the persistence of immune response to the viral vectored, mRNA and protein-based COVID-19 vaccine platforms used in homologous and... Read More about Persistence of immune response in heterologous COVID vaccination schedules in the Com-COV2 study – A single-blind, randomised trial incorporating mRNA, viral-vector and protein-adjuvant vaccines.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa (2023)
Journal Article
Dubern, J., Halliday, N., Cámara, M., Winzer, K., Barrett, D. A., Hardie, K. R., & Williams, P. (2023). Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa. Microbiology, 169(4), Article 001316. https://doi.org/10.1099/mic.0.001316

In Pseudomonas aeruginosa, quorum sensing (QS) depends on an interconnected regulatory hierarchy involving the Las, Rhl and Pqs systems, which are collectively responsible for the co-ordinated synthesis of a diverse repertoire of N-acylhomoserine lac... Read More about Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa.

An MltA-Like Lytic Transglycosylase Secreted by Bdellovibrio bacteriovorus Cleaves the Prey Septum during Predatory Invasion (2023)
Journal Article
Banks, E. J., Lambert, C., Mason, S. S., Tyson, J., Radford, P. M., McLaughlin, C., …Sockett, R. E. (2023). An MltA-Like Lytic Transglycosylase Secreted by Bdellovibrio bacteriovorus Cleaves the Prey Septum during Predatory Invasion. Journal of Bacteriology, 205(4), Article 00475-22. https://doi.org/10.1128/jb.00475-22

Lytic transglycosylases cut peptidoglycan backbones, facilitating a variety of functions within bacteria, including cell division, pathogenesis, and insertion of macromolecular machinery into the cell envelope. Here, we identify a novel role of a sec... Read More about An MltA-Like Lytic Transglycosylase Secreted by Bdellovibrio bacteriovorus Cleaves the Prey Septum during Predatory Invasion.

Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria (2023)
Journal Article
Ottonello, A., Wyllie, J. A., Yahiaoui, O., Sun, S., Koelln, R. A., Homer, J. A., …Moses, J. E. (2023). Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria. Proceedings of the National Academy of Sciences, 120(15), Article e2208737120. https://doi.org/10.1073/pnas.2208737120

The alarming rise in superbugs that are resistant to drugs of last resort, including vancomycin-resistant enterococci and staphylococci, has become a significant global health hazard. Here, we report the click chemistry synthesis of an unprecedented... Read More about Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria.

Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters (2023)
Journal Article
Ware, A., Jones, D. H., Flis, P., Chrysanthou, E., Smith, K. E., Kümpers, B. M., …Bishopp, A. (2023). Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters. Current Biology, 33(9), 1795-1802. https://doi.org/10.1016/j.cub.2023.03.025

Organ loss occurs frequently during plant and animal evolution. Sometimes, non-functional organs are retained through evolution. Vestigial organs are defined as genetically determined structures that have lost their ancestral (or salient) function. D... Read More about Loss of ancestral function in duckweed roots is accompanied by progressive anatomical reduction and a re-distribution of nutrient transporters.

G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells (2023)
Journal Article
Vassey, M., Firdaus, R., Aslam, A., Wheldon, L. M., Oldfield, N. J., Ala’Aldeen, D. A., & Wooldridge, K. G. (2023). G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells. Cellular Microbiology, 2023, 1-15. https://doi.org/10.1155/2023/7480033

Neisseria meningitidis is the most frequent cause of bacterial meningitis and is one of the few bacterial pathogens that can breach the blood-brain barrier (BBB). The 37/67 kDa laminin receptor (LamR) was previously identified as a receptor mediating... Read More about G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells.