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The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets (2007)
Journal Article
Richens, J., Fairclough, L., Ghaemmaghami, A. M., Mahdavi, J., Shakib, F., & Sewell, H. F. (2007). The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets. Immunobiology, 212(1), 29-38. https://doi.org/10.1016/j.imbio.2006.06.012

A disintegrin and metalloprotease (ADAM) proteins have wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion and intracellular signalling. Recent evidence suggests the involvement of ADAM8 in all... Read More about The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets.

Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics (2007)
Journal Article
Horlock, C., Shakib, F., Mahdavi, J., Jones, N. S., Sewell, H. F., & Ghaemmaghami, A. M. (2007). Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics. Genome Biology, 8(3), Article R30. https://doi.org/10.1186/gb-2007-8-3-r30

Background: Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood myeloid dendritic cells (mDCs) investigators have used differ... Read More about Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics.

CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut (2007)
Journal Article
Ashgar, S. S., Oldfield, N. J., Wooldridge, K. G., Jones, M. A., Irving, G. J., Turner, D. P., & Ala'Aldeen, D. A. (2007). CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut. Journal of Bacteriology, 189(5), 1856-1865. https://doi.org/10.1128/JB.01427-06

Two putative autotransporter proteins, CapA and CapB, were identified in silico from the genome sequence of Campylobacter jejuni NCTC11168. The genes encoding each protein contain homopolymeric tracts, suggestive of phase variation mediated by a slip... Read More about CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut.

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins. In R. J. Sugrue (Ed.), Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1007/978-1-59745-393-6_13

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.

Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins. In R. J. Sugrue (Ed.), Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1007/978-1-59745-393-6_13

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, expression, and functional analysis of patient-derived hepatitis C virus glycoproteins.

Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins (2007)
Book Chapter
Tarr, A. W., Owsianka, A. M., Szwejk, A., Ball, J. K., & Patel, A. H. (2007). Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins. In Glycovirology Protocols (177-197). Humana Press. https://doi.org/10.1385/1-59745-393-5%3A177

Hepatitis C virus (HCV) infection is a major cause of severe chronic liver disease including cirrhosis and hepatocellular carcinoma. HCV has been classified into six major genotypes that exhibit extensive genetic variability, particularly in the enve... Read More about Cloning, Expression, and Functional Analysis of Patient-Derived Hepatitis C Virus Glycoproteins.

Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes (2007)
Journal Article
Brown, R. J., Tarr, A. W., McClure, C. P., Juttla, V. S., Tagiuri, N., Irving, W. L., & Ball, J. K. (2007). Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes. Journal of General Virology, 88(2), 458-469. https://doi.org/10.1099/vir.0.82357-0

Investigation of the mechanisms underlying hepatitis C virus (HCV) envelope glycoprotein gene evolution will greatly assist rational development of broadly neutralizing antibody-based vaccines or vaccine components. Previously, comprehensive cross-ge... Read More about Cross-genotype characterization of genetic diversity and molecular adaptation in hepatitis C virus envelope glycoprotein genes.

Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters (2007)
Journal Article
Schuhler, S., Warner, A., Finney, N., Bennett, G. W., Ebling, F. J., & Brameld, J. M. (2007). Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters. Journal of Neuroendocrinology, 19(4), 239-249. https://doi.org/10.1111/j.1365-2826.2006.01524.x

Thyrotrophin-releasing hormone (TRH) is known to play an important role in the control of food intake and energy metabolism in addition to its actions on the pituitary-thyroid axis. We have previously shown that central administration of TRH decrease... Read More about Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters.

The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses (2007)
Journal Article
Furmonaviciene, R., Ghaemmaghami, A. M., Boyd, S. E., Jones, N. S., Bailey, K., Willis, A. C., …Shakib, F. (2007). The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses. Clinical and Experimental Allergy, 37(2), 231-242. https://doi.org/10.1111/j.1365-2222.2007.02651.x

Background: The cysteine protease Der p 1 from the house dust mite Dermatophagoides pteronyssinus is one of the most potent allergens known. An attractive mechanism for a component of Der p 1 allergenicity lies in its ability to cleave key regulatory... Read More about The protease allergen Der p 1 cleaves cell surface DC-SIGN and DC-SIGNR: Experimental analysis of in silico substrate identification and implications in allergic responses.

Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo (2007)
Journal Article
Stepek, G., Lowe, A., Buttle, D. J., Duce, I., & Behnke, J. M. (2007). Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo. Parasitology, 134(1), https://doi.org/10.1017/S0031182006001302

Cysteine proteinases from the fruit and latex of plants, including papaya, pineapple and fig, were previously shown to have a rapid detrimental effect, in vitro, against the rodent gastrointestinal nematodes, Heligmosomoides polygyrus (which is found... Read More about Anthelmintic action of plant cysteine proteinases against the rodent stomach nematode, Protospirura muricola, in vitro and in vivo.

Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes (2007)
Journal Article
Stepek, G., Curtis, R., Kerry, B., Shewry, P., Clark, S., Lowe, A., …Behnke, J. (2007). Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes. Parasitology, 134(12), https://doi.org/10.1017/S0031182007003289

Cysteine proteinases from the fruit and latex of plants, such as papaya, pineapple and fig, have previously been shown to have substantial anthelmintic efficacy, in vitro and in vivo, against a range of animal parasitic nematodes. In this paper, we d... Read More about Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes.

Molecular and morphological studies of Streptochilus from the Arabian Sea (2006)
Journal Article
Darling, K., Thomas, E., & Wade, C. (2006). Molecular and morphological studies of Streptochilus from the Arabian Sea. 00 Journal not listed, 29(1), 187--187. https://doi.org/10.11137/2006_1_187-187

Specimens of the biserial planktonic foraminiferal genus Streptochilus were collected 540 nautical miles offshore in the central Arabian Sea during the summer monsoon of 2003. Samples were collected from 5m water depth in waters with an average depth... Read More about Molecular and morphological studies of Streptochilus from the Arabian Sea.

Quaternary climate instability as the driver of genetic diversification in Neogloboquadrina pachyderma (sin) (2006)
Journal Article
Darling, K., Kucera, M., & Wade, C. (2006). Quaternary climate instability as the driver of genetic diversification in Neogloboquadrina pachyderma (sin). 00 Journal not listed, 29(1), 533. https://doi.org/10.11137/2006_1_533-533

Molecular genetic analysis shows that many planktonic foraminiferal morphospecies represent complexes of several distinct genetic types with distinct ecologies and distributions. Such cryptic diversity is common in most planktonic protists. Global bi... Read More about Quaternary climate instability as the driver of genetic diversification in Neogloboquadrina pachyderma (sin).

Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning (2006)
Journal Article
O'Sullivan, N. C., McGettigan, P. A., Sheridan, G. K., Pickering, M., Conboy, L., O'Connor, J. J., …Murphy, K. J. (2007). Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning. Journal of Neurochemistry, 101(4), 1085-1098. https://doi.org/10.1111/j.1471-4159.2006.04418.x

A learning event initiates a cascade of altered gene expression leading to synaptic remodelling within the hippocampal dentate gyrus, a structure vital to memory formation. To illuminate this transcriptional program of synaptic plasticity we used mic... Read More about Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning.

Asthma as a barrier to children's physical activity: Implications for body mass index and mental health (2006)
Journal Article
Glazebrook, C., McPherson, A. C., Macdonald, I. A., Swift, J. A., Ramsay, C., Newbould, R., & Smyth, A. (2006). Asthma as a barrier to children's physical activity: Implications for body mass index and mental health. Pediatrics, 118(6), 2443-2449. https://doi.org/10.1542/peds.2006-1846

OBJECTIVES. The purpose of this work was to identify barriers to physical activity in children with asthma and to compare their customary activity levels, BMI and emotional well-being with that of children with other medical conditions. It was hypoth... Read More about Asthma as a barrier to children's physical activity: Implications for body mass index and mental health.

Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages (2006)
Journal Article
Rosas-Magallanes, V., Stadthagen-Gomez, G., Rauzier, J., Barreiro, L. B., Tailleux, L., Boudou, F., Griffin, R., Nigou, J., Jackson, M., Gicquel, B., & Neyrolles, O. (2007). Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infection and Immunity, 75(1), 504-507. https://doi.org/10.1128/IAI.00058-06

Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-enco... Read More about Signature-tagged transposon mutagenesis identifies novel mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells (2006)
Journal Article
Oldfield, N. J., Bland, S. J., Taraktsoglou, M., Dos Ramos, F. J., Robinson, K., Wooldridge, K. G., & Ala'Aldeen, D. A. (2007). T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells. Cellular Microbiology, 9(2), 463-478. https://doi.org/10.1111/j.1462-5822.2006.00803.x

T-cell stimulating protein A (TspA) is an immunogenic, T-cell and B-cell stimulating protein of Neisseria meningitidis. Sequence similarity between TspA and FimV, a Pseudomonas aeruginosa protein involved in twitching motility, suggested a link betwe... Read More about T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells.

Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding (2006)
Journal Article
Owsianka, A. M., Timms, J. M., Tarr, A. W., Brown, R. J., Hickling, T. P., Szwejk, A., …Ball, J. K. (2006). Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding. Journal of Virology, 80(17), 8695-8704. https://doi.org/10.1128/JVI.00271-06

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 determinants important for successful binding will facilitate development of entry inhibi... Read More about Identification of Conserved Residues in the E2 Envelope Glycoprotein of the Hepatitis C Virus That Are Critical for CD81 Binding.

Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus (2006)
Journal Article
Warfield, R., Bardelang, P., Saunders, H., Chan, W. C., Penfold, C., James, R., & Thomas, N. R. (2006). Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus. Organic and Biomolecular Chemistry, 4(19), 3626-3638. https://doi.org/10.1039/b607999g

Lysostaphin (EC. 3.4.24.75) is a protein secreted by Staphylococcus simulans biovar staphylolyticus and has been shown to be active against methicillin resistant S. aureus (MRSA). The design and synthesis of three internally quenched substrates for l... Read More about Internally quenched peptides for the study of lysostaphin: An antimicrobial protease that kills Staphylococcus aureus.