All Outputs (184)

Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger (2020)
Journal Article
Geoghegan, I. A., Stratford, M., Bromley, M., Archer, D. B., & Avery, S. V. (2020). Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger. mSphere, 5(1), https://doi.org/10.1128/msphere.00685-19

Copyright © 2020 Geoghegan et al. Propionic, sorbic, and benzoic acids are organic weak acids that are widely used as food preservatives, where they play a critical role in preventing microbial growth. In this study, we uncovered new mechanisms of we... Read More about Weak Acid Resistance A (WarA), a Novel Transcription Factor Required for Regulation of Weak-Acid Resistance and Spore-Spore Heterogeneity in Aspergillus niger.

Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation (2020)
Journal Article
Brookfield, J. F. (2020). Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation. Current Biology, 30(1), R16-R18. https://doi.org/10.1016/j.cub.2019.11.040

© 2019 Elsevier Ltd New data are causing the standard model for the effect of selection on linked neutral variation in low recombination regions, combining the effects of background selection and selective sweeps, to be refined to include harmful rec... Read More about Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation.

Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector (2020)
Journal Article
Alcocer, M., Paes, M. C., Sang, F., Saraiva, F. M. S., Pane, A., Nogueira, N. P., …Dias, F. A. (2020). Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector. PLoS Neglected Tropical Diseases, 14(1), e0007945. https://doi.org/10.1371/journal.pntd.0007945

Chagas disease, also known as American trypanosomiasis, is a potentially life-threatening illness caused by the protozoan parasite, Trypanosoma cruzi, and is transmitted by triatomine insects during its blood meal. Proliferative epimastigotes forms t... Read More about Gene expression profiling of Trypanosoma cruzi in the presence of heme points to glycosomal metabolic adaptation of epimastigotes inside the vector.

Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain (2020)
Journal Article
Gowler, P. R., Li, L., Woodhams, S. G., Bennett, A. J., Suzuki, R., Walsh, D. A., & Chapman, V. (2020). Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain. PAIN, 161(1), 61-73. https://doi.org/10.1097/j.pain.0000000000001694

Brain-derived neurotrophic factor (BDNF) and the high-affinity receptor tropomyosin receptor kinase B (TrkB) have important roles in neuronal survival and in spinal sensitization mechanisms associated with chronic pain. Recent clinical evidence also... Read More about Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain.