All Outputs (3)

Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids (2021)
Journal Article
Cirillo, S., Tomeh, M. A., Wilkinson, R. N., Hill, C., Brown, S., & Zhao, X. (2021). Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids. ACS Applied Materials and Interfaces, 13(42), 49713-49728. https://doi.org/10.1021/acsami.1c14761

Antimicrobial/anticancer peptides (AMPs/ACPs) have shown promising results as new therapeutic agents in cancer thearpy. Among them, the designed amphiphilic α-helical peptide G(IIKK)3I-NH2 (G3) displayed great affinity and specificity in targeting ca... Read More about Designed Antitumor Peptide for Targeted siRNA Delivery into Cancer Spheroids.

Zebrafish as a tractable model of human cardiovascular disease (2021)
Journal Article
Bowley, G., Kugler, E., Wilkinson, R., Lawrie, A., Eeden, F., Chico, T. J. A., …Serbanovic‐Canic, J. (2022). Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. https://doi.org/10.1111/bph.15473

Mammalian models including non-human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value... Read More about Zebrafish as a tractable model of human cardiovascular disease.

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development (2021)
Journal Article
Derrick, C. J., Sánchez-Posada, J., Hussein, F., Tessadori, F., Pollitt, E. J. G., Savage, A. M., …Noël, E. S. (2022). Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research, 118(1), 226-240. https://doi.org/10.1093/cvr/cvab004

Aims: Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionaliz... Read More about Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development.