All Outputs (209)
Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes (2016)
Journal Article
Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely... Read More about Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes.
Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke (2016)
Journal Article
Background: Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke. The completed Efficacy of Nitr... Read More about Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.
Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry (2016)
Journal Article
The use of functionalised recombinant spider silk as a sustainable advanced biomaterial is currently an area of intense interest owing to spider silk’s intrinsic strength, toughness, biocompatibility and biodegradability. This paper demonstrates, for... Read More about Antibiotic Spider Silk: Site-Specific Functionalization of Recombinant Spider Silk Using “Click” Chemistry.
Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and ?-Aminobutyric Acid Release (2016)
Journal Article
© 2017 by the American Diabetes Association. Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic... Read More about Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and ?-Aminobutyric Acid Release.
Exploring the shell-based taxonomy of the Sri Lankan land snail Corilla H. and A. Adams, 1855 (Pulmonata: Corillidae) using mitochondrial DNA (2016)
Journal Article
The land-snail genus Corilla is endemic to Sri Lanka and India’s Western Ghats. The ten extant Sri Lankan species belong to two distinct shell forms that are associated respectively with lowland and montane rainforest. We here present the first molec... Read More about Exploring the shell-based taxonomy of the Sri Lankan land snail Corilla H. and A. Adams, 1855 (Pulmonata: Corillidae) using mitochondrial DNA.
Which traits do observers use to distinguish Batesian mimics from their models? (2016)
Journal Article
Batesian mimicry, in which a harmless mimic resembles a more aversive model, can encompass a wide range of morphological traits, but the resemblance is never perfect. Previous studies have used abstract “prey” designs to show that differences in cert... Read More about Which traits do observers use to distinguish Batesian mimics from their models?.
5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus (2016)
Journal Article
Objectives: Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradec... Read More about 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus.
Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes (2016)
Journal Article
Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT th... Read More about Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes.
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss (2016)
Journal Article
The current frontline symptomatic treatment for Alzheimer’s disease (AD) is whole-body upregulation of cholinergic transmission via inhibition of acetylcholinesterase. This approach leads to profound dose-related adverse effects. An alternative strat... Read More about M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats (2016)
Journal Article
VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms invo... Read More about Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.
A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease (2016)
Journal Article
Alzheimer's disease (AD), the predominant form of dementia, is highly correlated with the abnormal hyperphosphorylation and aggregation of tau. Immune responses are key drivers of AD and how they contribute to tau pathology in human disease remains l... Read More about A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease.
The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover (2016)
Journal Article
The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regul... Read More about The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover.
A streamlined acquisition for mapping baseline brain oxygenation using quantitative BOLD (2016)
Journal Article
Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition (2016)
Journal Article
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and P... Read More about Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition.
No evidence of local adaptation of immune responses to Gyrodactylus in three-spined stickleback (Gasterosteus aculeatus) (2016)
Journal Article
© 2016 The Authors Parasitism represents one of the most widespread lifestyles in the animal kingdom, with the potential to drive coevolutionary dynamics with their host population. Where hosts and parasites evolve together, we may find local adaptat... Read More about No evidence of local adaptation of immune responses to Gyrodactylus in three-spined stickleback (Gasterosteus aculeatus).
What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives (2016)
Journal Article
Clostridium difficile is a major cause of antibiotic induced diarrhoea worldwide, responsible for significant annual mortalities and represents a considerable economic burden on healthcare systems. The two main C. difficile virulence factors are toxi... Read More about What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives.
Seasonal and Spatial Variations of Saltmarsh Benthic Foraminiferal Communities from North Norfolk, England (2016)
Journal Article
© 2016, The Author(s). Time series foraminiferal data were obtained from samples collected from three sites at Brancaster Overy Staithe, Burnham Overy Staithe and Thornham on the North Norfolk coast over a 1-year period. At each collection point, six... Read More about Seasonal and Spatial Variations of Saltmarsh Benthic Foraminiferal Communities from North Norfolk, England.
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity (2016)
Journal Article
© 2016 Background Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss. We investigated whether anabolic resistance to feeding might underlie accelerated muscle loss in older people with T2DM and whether dysregulated m... Read More about Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.