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The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover

Zhou, Lian; Zhang, Lian-Hui; Cámara, Miguel; He, Ya-Wen

Authors

Lian Zhou

Lian-Hui Zhang

Miguel Cámara

Ya-Wen He



Abstract

The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment.

Journal Article Type Article
Publication Date Apr 1, 2017
Journal Trends in Microbiology
Print ISSN 0966-842X
Electronic ISSN 1878-4380
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 4
APA6 Citation Zhou, L., Zhang, L., Cámara, M., & He, Y. (2017). The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25(4), doi:10.1016/j.tim.2016.11.013
DOI https://doi.org/10.1016/j.tim.2016.11.013
Keywords Quorum sensing, DSF, Biosynthesis, Naturally occurring signal turnover, Xanthomonas
Publisher URL http://dx.doi.org/10.1016/j.tim.2016.11.013
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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