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The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover

Zhou, Lian; Zhang, Lian-Hui; C�mara, Miguel; He, Ya-Wen

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Authors

Lian Zhou

Lian-Hui Zhang

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MIGUEL CAMARA MIGUEL.CAMARA@NOTTINGHAM.AC.UK
Professor of Molecular Microbiology

Ya-Wen He



Abstract

The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regulate diverse biological functions. Recently, substantial progress has been made on the characterization of new members of this family of signals. There have also been new developments in the understanding of the biosynthesis of these molecules where dual enzymatic activities of the DSF synthase and the use of various substrates have been described. The recent discovery of a naturally occurring DSF turnover mechanism and its regulation provides a new dimension in our understanding of how DSF-dependent microorganisms modulate virulence gene expression in response to changes in the surrounding environment.

Citation

Zhou, L., Zhang, L., Cámara, M., & He, Y. (2017). The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25(4), https://doi.org/10.1016/j.tim.2016.11.013

Journal Article Type Article
Acceptance Date Nov 20, 2016
Online Publication Date Dec 12, 2016
Publication Date Apr 1, 2017
Deposit Date Feb 9, 2017
Publicly Available Date Mar 28, 2024
Journal Trends in Microbiology
Print ISSN 0966-842X
Electronic ISSN 1878-4380
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Issue 4
DOI https://doi.org/10.1016/j.tim.2016.11.013
Keywords Quorum sensing, DSF, Biosynthesis, Naturally occurring signal turnover, Xanthomonas
Public URL https://nottingham-repository.worktribe.com/output/854257
Publisher URL http://dx.doi.org/10.1016/j.tim.2016.11.013

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