All Outputs (2)

A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine (2013)
Journal Article
Barthelme, A., Richards, D., Mellor, I. R., & Stockman, R. A. (2013). A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (+/-)-xenovenine. Chemical Communications, 49(89), https://doi.org/10.1039/c3cc46800c

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon (2013)
Journal Article
Rosini, M., Simoni, E., Bartolini, M., Soriano, E., Marco-Contelles, J., Andrisano, V., …Bolognesi, M. L. (2013). The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon. ChemMedChem, 8(8), 1276-1281. https://doi.org/10.1002/cmdc.201300263

Inspired by the concept of bivalent ligands, we prepared a small set of analogues of the drug candidate dimebon. They were shown to inhibit AChE, Aβ42 aggregation, and NMDA receptor activation to a greater extent than dimebon. Some of these compounds... Read More about The bivalent ligand approach as a tool for improving the in vitro anti-alzheimer multitarget profile of dimebon.