All Outputs (2179)

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense (2024)
Journal Article
Silvester, E., Szoor, B., Ivens, A., Awuah-Mensah, G., Gadelha, C., Wickstead, B., & Matthews, K. R. (2024). A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense. PLoS Pathogens, 20(2), Article e1011889. https://doi.org/10.1371/journal.ppat.1011889

Trypanosomatid parasites undergo developmental regulation to adapt to the different environments encountered during their life cycle. In Trypanosoma brucei, a genome wide selectional screen previously identified a regulator of the protein family ESAG... Read More about A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.

Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings (2024)
Journal Article
Robertson, S. N., Romero, M., Fenn, S., Riedi, P. L. K., & Cámara, M. (2024). Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings. Journal of Applied Microbiology, 135(3), Article lxae042. https://doi.org/10.1093/jambio/lxae042

Chronic wound infections are generally of polymicrobial nature with aerobic and anaerobic bacteria, as well as fungi frequently observed in them. Wound treatment involves a series of steps, including debridement of the wound, flushing, and often the... Read More about Development, characterization, and evaluation of a simple polymicrobial colony biofilm model for testing of antimicrobial wound dressings.

GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia (2024)
Journal Article
Cale, J. A., Chauhan, E. J., Cleaver, J. J., Fusciardi, A. R., McCann, S., Waters, H. C., …King, M. V. (2024). GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia. Molecular Neurobiology, https://doi.org/10.1007/s12035-024-03987-y

The pathogenesis of schizophrenia begins in early neurodevelopment and leads to excitatory-inhibitory imbalance. It is therefore essential that preclinical models used to understand disease, select drug targets and evaluate novel therapeutics encompa... Read More about GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia.

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids (2024)
Journal Article
Suvannapruk, W., Fisher, L. E., Luckett, J. C., Edney, M. K., Kotowska, A. M., Kim, D., …Alexander, M. R. (2024). Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids. Advanced Science, 11(15), Article 2306000. https://doi.org/10.1002/advs.202306000

A key goal for implanted medical devices is that they do not elicit a detrimental immune response. Macrophages play critical roles in modulation of the host immune response and are the major cells responsible for persistent inflammatory reactions to... Read More about Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS highlights a critical role for lipids.

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake (2024)
Journal Article
Ham, S., Mukaida, S., Sato, M., Keov, P., Bengtsson, T., Furness, S., …Hutchinson, D. S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12(1), Article e1176. https://doi.org/10.1002/prp2.1176

Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylat... Read More about Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake.

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing (2024)
Journal Article
Salim, B., Nakao, R., Chatanga, E., Marcuzzi, O., Eissawi, M. A., Almathen, F., …Giovambattista, G. (2024). Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing. BMC Genomics, 25(1), Article 160. https://doi.org/10.1186/s12864-024-10053-3

Introduction The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar... Read More about Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

The evolution of the duckweed ionome mirrors losses in structural complexity (2024)
Journal Article
Smith, K. E., Zhou, M., Flis, P., Jones, D., Bishopp, A., & Yant, L. (in press). The evolution of the duckweed ionome mirrors losses in structural complexity. Annals of Botany, Article mcae012. https://doi.org/10.1093/aob/mcae012

Background and Aims The duckweeds (Lemnaceae) consist of 36 species exhibiting impressive phenotypic variation, including the progressive evolutionary loss of a fundamental plant organ, the root. Loss of roots and reduction of vascular tissues in re... Read More about The evolution of the duckweed ionome mirrors losses in structural complexity.

Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance (2024)
Journal Article
Kasza, K., Richards, B., Jones, S., Romero, M., Robertson, S. N., Hardie, K. R., …Alexander, C. (2024). Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance. ACS Applied Materials and Interfaces, 16(5), 5412-5425. https://doi.org/10.1021/acsami.3c14357

To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial biofilms are a particular concern in this context as they are responsible for over 80% of bacterial infections and are inherently more... Read More about Ciprofloxacin poly(β-amino ester) conjugates enhance antibiofilm activity and slow the development of resistance.

Whole-genome resource sequences of 57 indigenous Ethiopian goats (2024)
Journal Article
Belay, S., Belay, G., Nigussie, H., Jian-Lin, H., Tijjani, A., Ahbara, A. M., …Mwacharo, J. M. (2024). Whole-genome resource sequences of 57 indigenous Ethiopian goats. Scientific Data, 11(1), Article 139. https://doi.org/10.1038/s41597-024-02973-2

Domestic goats are distributed worldwide, with approximately 35% of the one billion world goat population occurring in Africa. Ethiopia has 52.5 million goats, ~99.9% of which are considered indigenous landraces deriving from animals introduced to th... Read More about Whole-genome resource sequences of 57 indigenous Ethiopian goats.

Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress (2024)
Journal Article
Rachman, M. P., Bamidele, O., Dessie, T., Smith, J., Hanotte, O., & Gheyas, A. A. (2024). Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress. Scientific Reports, 14(1), Article 2209. https://doi.org/10.1038/s41598-024-52569-4

Indigenous poultry breeds from Africa can survive in harsh tropical environments (such as long arid seasons, excessive rain and humidity, and extreme heat) and are resilient to disease challenges, but they are not productive compared to their commerc... Read More about Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress.

Age-related impact of social isolation in mice: Young vs middle-aged (2024)
Journal Article
Magalhães, D. M., Mampay, M., Sebastião, A. M., Sheridan, G. K., & Valente, C. A. (2024). Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry International, 174, Article 105678. https://doi.org/10.1016/j.neuint.2024.105678

Social isolation is a chronic mild stressor and a significant risk factor for mental health disorders. Herein we explored the impact of social isolation on depression- and anxiety-like behaviours, as well as spatial memory impairments, in middle-aged... Read More about Age-related impact of social isolation in mice: Young vs middle-aged.

Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., …Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.

Reproductive isolation in a three‐way contact zone (2024)
Journal Article
Dean, L. L., Whiting, J. R., Jones, F. C., & MacColl, A. D. C. (2024). Reproductive isolation in a three‐way contact zone. Molecular Ecology, 33(5), Article e17275. https://doi.org/10.1111/mec.17275

Contact zones between divergent forms within a species provide insight into the role of gene flow in adaptation and speciation. Previous work has focused on contact zones involving only two divergent forms, but in nature, many more than two populatio... Read More about Reproductive isolation in a three‐way contact zone.

MicroRNA expression profile of chicken jejunum in different time points Eimeria maxima infection (2024)
Journal Article
Jebessa, E., Bello, S. F., Guo, L., Tuli, M. D., Hanotte, O., & Nie, Q. (2024). MicroRNA expression profile of chicken jejunum in different time points Eimeria maxima infection. Frontiers in Immunology, 14, Article 1331532. https://doi.org/10.3389/fimmu.2023.1331532

Coccidiosis stands as a protozoan disease of notable economic impact, characterized by an intracellular parasite that exerts substantial influence over poultry production. This invasion disrupts the integrity of the enteric mucosa, leading to the eme... Read More about MicroRNA expression profile of chicken jejunum in different time points Eimeria maxima infection.

Phylogeography of a commercially important reef fish, Lutjanus ehrenbergii, from the coastal waters of the Arabian Peninsula (2024)
Journal Article
Griffiths, M. H., Wade, C. M., D’Agostino, D., Berumen, M. L., Burt, J. A., DiBattista, J. D., & Feary, D. A. (2024). Phylogeography of a commercially important reef fish, Lutjanus ehrenbergii, from the coastal waters of the Arabian Peninsula. Biological Journal of the Linnean Society, https://doi.org/10.1093/biolinnean/blad170

The coastal waters of the Arabian Peninsula include a heterogeneous marine region comprising the Persian/Arabian Gulf and Sea of Oman at its northeastern boundary and the Arabian Sea, Gulf of Aden, and Red Sea at its southern and western boundary. Th... Read More about Phylogeography of a commercially important reef fish, Lutjanus ehrenbergii, from the coastal waters of the Arabian Peninsula.

Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China (2024)
Journal Article
Baker, M., Zhang, X., Maciel-Guerra, A., Babaarslan, K., Dong, Y., Wang, W., …Dottorini, T. (2024). Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China. Nature Communications, 15, Article 206. https://doi.org/10.1038/s41467-023-44272-1

Sharing of genetic elements among different pathogens and commensals inhabiting same hosts and environments has significant implications for antimicrobial resistance (AMR), especially in settings with high antimicrobial exposure. We analysed 661 Esch... Read More about Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China.

Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts (2024)
Journal Article
Caulton, S. G., Lambert, C., Tyson, J., Radford, P., Al-Bayati, A., Greenwood, S., …Lovering, A. L. (2024). Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts. Nature Microbiology, 9(1), 214-227. https://doi.org/10.1038/s41564-023-01552-2

Predatory bacteria, like the model endoperiplasmic bacterium Bdellovibrio bacteriovorus, show several adaptations relevant to their requirements for locating, entering and killing other bacteria. The mechanisms underlying prey recognition and handlin... Read More about Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts.

Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections (2024)
Journal Article
Soukarieh, F., Mashabi, A., Richardson, W., Oton, E. V., Romero, M., Dubern, J., …Cámara, M. (2024). Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections. Journal of Medicinal Chemistry, 67(2), 1008-1023. https://doi.org/10.1021/acs.jmedchem.3c00973

Pseudomonas aeruginosa is one of the top priority pathogens that requires immediate attention according to the World Health Organisation (WHO). Due to the alarming shortage of novel antimicrobials, targeting quorum sensing (QS), a bacterial cell to c... Read More about Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.

Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats (2023)
Journal Article
Pannucci, P., Van Daele, M., Cooper, S. L., Wragg, E. S., March, J., Groenen, M., …Woolard, J. (2023). Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats. Biochemical Pharmacology, Article 116007. https://doi.org/10.1016/j.bcp.2023.116007

Receptor tyrosine kinase inhibitors (RTKIs) suppress tumour growth by targeting vascular endothelial growth factor receptor 2 (VEGFR-2) which is an important mediator of angiogenesis. Here, we demonstrate that two potent RTKIs, axitinib and lenvatini... Read More about Role of endothelin ETA receptors in the hypertension induced by the VEGFR-2 kinase inhibitors axitinib and lenvatinib in conscious freely-moving rats.

Mapping restricted introgression across the genomes of admixed indigenous African cattle breeds (2023)
Journal Article
Friedrich, J., Bailey, R. I., Talenti, A., Chaudhry, U., Ali, Q., Obishakin, E. F., …Wiener, P. (2023). Mapping restricted introgression across the genomes of admixed indigenous African cattle breeds. Genetics Selection Evolution, 55(1), Article 91. https://doi.org/10.1186/s12711-023-00861-8

Background: The genomes of indigenous African cattle are composed of components with Middle Eastern (taurine) and South Asian (indicine) origins, providing a valuable model to study hybridization and to identify genetic barriers to gene flow. In this... Read More about Mapping restricted introgression across the genomes of admixed indigenous African cattle breeds.