All Outputs (11)

Metal Resistance and Its Association With Antibiotic Resistance (2017)
Book Chapter
Pal, C., Asiani, K. R., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. J., & Hobman, J. L. (2017). Metal Resistance and Its Association With Antibiotic Resistance. In R. K. Poole (Ed.), Microbiology of metal ions (261-313). Academic Press. https://doi.org/10.1016/bs.ampbs.2017.02.001

Antibiotic resistance is recognised as a major global threat to public health by the World Health Organization. Currently, several hundred thousand deaths yearly can be attributed to infections with antibiotic-resistant bacteria. The major driver for... Read More about Metal Resistance and Its Association With Antibiotic Resistance.

Bacterial resistance to arsenic protects against protist killing (2017)
Journal Article
Hao, X., Li, X., Pal, C., Hobman, J. L., Larsson, D. J., Saquib, Q., …Rensing, C. (2017). Bacterial resistance to arsenic protects against protist killing. BioMetals, 30(2), 307-311. https://doi.org/10.1007/s10534-017-0003-4

Protists kill their bacterial prey using toxic metals such as copper. Here we hypothesize that the metalloid arsenic has a similar role. To test this hypothesis, we examined intracellular survival of Escherichia coli (E. coli) in the amoeba Dictyoste... Read More about Bacterial resistance to arsenic protects against protist killing.

Draft genome sequence of the bacteriophage vB_Eco_slurp01. (2016)
Journal Article
Sazinas, P., Smith, C., Suhaimi, A., Hobman, J. L., Dodd, C. E., & Millard, A. (2016). Draft genome sequence of the bacteriophage vB_Eco_slurp01. Genome Announcements, 4(6), https://doi.org/10.1128/genomeA.01111-16

Bacteriophage vB_Eco_slurp01 was isolated from porcine feces using Escherichia coli MG1655 as a host. With a genome size of 348 kb, vB_Eco_slurp01 is one of the largest bacteriophages isolated to date.

Multidrug resistant, extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm (2016)
Journal Article
Ibrahim, D. R., Dodd, C. E. R., Stekel, D. J., Ramsden, S. J., & Hobman, J. L. (2016). Multidrug resistant, extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm. FEMS Microbiology Ecology, 92(4), Article fiw013. https://doi.org/10.1093/femsec/fiw013

Escherichia coli strains were isolated from a single dairy farm as a sentinel organism for the persistence of antibiotic resistance genes in the farm environment. Selective microbiological media were used to isolate 126 E. coli isolates from slurry a... Read More about Multidrug resistant, extended spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from a dairy farm.

Draft genome sequences of 14 Escherichia coli phages isolated from cattle slurry (2015)
Journal Article
Smith, R., O'Hara, M., Hobman, J. L., & Millard, A. (2015). Draft genome sequences of 14 Escherichia coli phages isolated from cattle slurry. Genome Announcements, 3(6), Article e01364-15. https://doi.org/10.1128/genomeA.01364-15

The diversity of bacteriophages in slurry from dairy cows remains largely unknown. Here, we report the draft genome sequences of 14 bacteriophages isolated from dairy cow slurry using Escherichia coli K-12 MG1655 as a host.

Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island" (2015)
Journal Article
Hao, X., Luthje, F. L., Qin, Y., McDevitt, S. F., Lutay, N., Hobman, J. L., …Rensing, C. (2015). Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island". Applied Microbiology and Biotechnology, 99(14), https://doi.org/10.1007/s00253-015-6749-0

The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. Whi... Read More about Survival in amoeba: a major selection pressure on the presence of bacterial copper and zinc resistance determinants?: identification of a "copper pathogenicity island".

Bacterial antimicrobial metal ion resistance (2015)
Journal Article
Hobman, J. L., & Crossman, L. (2015). Bacterial antimicrobial metal ion resistance. Journal of Medical Microbiology, 64, https://doi.org/10.1099/jmm.0.023036-0

Metals such as mercury, arsenic, copper and silver have been used in various forms as antimicrobials for thousands of years with until recently, little understanding of their mode of action. The discovery of antibiotics and new organic antimicrobial... Read More about Bacterial antimicrobial metal ion resistance.

The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress (2015)
Journal Article
Takahashi, H., Oshima, T., Hobman, J. L., Doherty, N., Clayton, S. R., Iqbal, M., …Stekel, D. J. (2015). The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress. Interface, 12(106), Article 20150069. https://doi.org/10.1098/rsif.2015.0069

Zinc is essential for life, but toxic in excess. Thus all cells must control their internal zinc concentration. We used a systems approach, alternating rounds of experiments and models, to further elucidate the zinc control systems in Escherichia col... Read More about The dynamic balance of import and export of zinc in Escherichia coli suggests a heterogeneous population response to stress.

Response of Cupriavidus metallidurans CH34 to metals (2015)
Book Chapter
Monsieurs, P., Hobman, J. L., Vandenbussche, G., Mergeay, M., & Van Hoult, R. (2015). Response of Cupriavidus metallidurans CH34 to metals. In M. Mergay, & R. Van Houdt (Eds.), Metal response in Cupriavidus metallidurans Volume 1: From habitats to genes and proteins. Springer. https://doi.org/10.1007/978-3-319-20594-6

Cupriavidus metallidurans CH34 displays resistance to a plethora of metals. Its response and underlying genetic determinants are dissected and detailed metal by metal (from arsenic to zinc). An important role for its megaplasmids pMOL28 and pMOL30 is... Read More about Response of Cupriavidus metallidurans CH34 to metals.

High-resolution mapping of in vivo genomic transcription factor binding sites using in situ DNase I footprinting and ChIP-seq (2013)
Journal Article
Chumsakul, O., Nakamura, K., Kurata, T., Hobman, J. L., Ogasawara, N., Oshima, T., & Ishikawa, S. (2013). High-resolution mapping of in vivo genomic transcription factor binding sites using in situ DNase I footprinting and ChIP-seq. DNA Research, 20(4), https://doi.org/10.1093/dnares/dst013

Accurate identification of the DNA-binding sites of transcription factors and other DNA-binding proteins on the genome is crucial to understanding their molecular interactions with DNA. Here, we describe a new method: Genome Footprinting by high-thro... Read More about High-resolution mapping of in vivo genomic transcription factor binding sites using in situ DNase I footprinting and ChIP-seq.

Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis (2013)
Journal Article
Browning, D., Wells, T., Franca, F., Morris, F., Sevastyanovich, Y., Bryant, J., …Henderson, I. (2013). Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis. Molecular Microbiology, 87(5), https://doi.org/10.1111/mmi.12144

Escherichia coli has been the leading model organism for many decades. It is a fundamental player in modern biology, facilitating the molecular biology revolution of the last century. The acceptance of E.?coli as model organism is predicated primaril... Read More about Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis.