All Outputs (38)

Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold (2024)
Journal Article
Anand-Ivell, R., Heng, K., Antonio, L., Bartfai, G., Casanueva, F. F., Maggi, M., …Ivell, R. (2024). Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold. Aging Male, 27(1), Article 2346322. https://doi.org/10.1080/13685538.2024.2346322

Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism. Using results from large cohort studies we explore sources of bi... Read More about Insulin-like peptide 3 (INSL3) as an indicator of leydig cell insufficiency (LCI) in Middle-aged and older men with hypogonadism: reference range and threshold.

INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis (2024)
Journal Article
Anand-Ivell, R., Coutinho, A. R., Dai, Y., England, G., Goericke-Pesch, S., & Ivell, R. (2024). INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis. Animals, 14(5), Article 675. https://doi.org/10.3390/ani14050675

Insulin-like peptide 3 (INSL3) is a constitutive product of mature, adult-type Leydig cells of the testes and consequently in most mammals is an ideal biomarker with which to monitor pubertal development. A new heterologous time-resolved fluorescence... Read More about INSL3 Variation in Dogs Following Suppression and Recovery of the HPG Axis.

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men (2022)
Journal Article
Abbara, A., Koysombat, K., Phylactou, M., Chia Eng, P., Clarke, S., Comninos, A. N., …Dhillo, W. S. (2022). Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men. Frontiers in Endocrinology, 13, Article 1076984. https://doi.org/10.3389/fendo.2022.1076984

Background: Delayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH). Establishing the cause at presentation is challenging, with “red flag” fea... Read More about Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men.

The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort (2022)
Journal Article
Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., …Anand-Ivell, R. (2022). The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort. Frontiers in Endocrinology, 13, Article 1016107. https://doi.org/10.3389/fendo.2022.1016107

Background: Insulin-like peptide 3 (INSL3) is a constitutive hormone secreted in men by the mature Leydig cells of the testes. It is an accurate biomarker for Leydig cell functional capacity, reflecting their total cell number and differentiation sta... Read More about The Leydig cell biomarker INSL3 as a predictor of age-related morbidity: Findings from the EMAS cohort.

Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study (2022)
Journal Article
Ivell, R., Vinggaard, A. M., Soyama, H., & Anand-Ivell, R. (2022). Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study. Andrologia, 54(11), Article e14566. https://doi.org/10.1111/and.14566

Insulin-like peptide 3 (INSL3) is a peptide biomarker secreted specifically by the mature Leydig cells of the testes. It is constitutive, has low within-individual variance, and effectively measures the functional capacity of Leydig cells to make tes... Read More about Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study.

Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort (2022)
Journal Article
Anand-Ivell, R., Heng, K., Severn, K., Antonio, L., Bartfai, G., Casanueva, F. F., …Ivell, R. (2022). Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort. Andrology, 10(7), 1328-1338. https://doi.org/10.1111/andr.13220

Background: Aging in men is accompanied by a broad range of symptoms, including sexual dysfunction, cognitive and musculoskeletal decline, obesity, type 2 diabetes, cardiovascular disease and hypertension, organ degeneration/failure, and increasing n... Read More about Association of age, hormonal, and lifestyle factors with the Leydig cell biomarker INSL3 in aging men from the European Male Aging Study cohort.

Expression and Role of INSL3 in the Fetal Testis (2022)
Journal Article
Ivell, R., Mamsen, L. S., Andersen, C. Y., & Anand-Ivell, R. (2022). Expression and Role of INSL3 in the Fetal Testis. Frontiers in Endocrinology, 13, Article 868313. https://doi.org/10.3389/fendo.2022.868313

Insulin-like peptide 3 (INSL3) is a small peptide hormone of the insulin-relaxin family which is produced and secreted by the fetal Leydig cells in the testes only. It appears to be undetectable in female fetuses. In the human fetus INSL3 synthesis b... Read More about Expression and Role of INSL3 in the Fetal Testis.

Maternal exposure to dibutyl phthalate (Dbp) or diethylstilbestrol (des) leads to long-term changes in hypothalamic gene expression and sexual behavior (2021)
Journal Article
Hunter, D., Heng, K., Mann, N., Anand-Ivell, R., & Ivell, R. (2021). Maternal exposure to dibutyl phthalate (Dbp) or diethylstilbestrol (des) leads to long-term changes in hypothalamic gene expression and sexual behavior. International Journal of Molecular Sciences, 22(8), 1-14. https://doi.org/10.3390/ijms22084163

Xenobiotic exposure during pregnancy and lactation has been linked to perinatal changes in male reproductive outcomes and other endocrine parameters. This pilot study wished to assess whether brief maternal exposure of rats to xenobiotics dibutyl pht... Read More about Maternal exposure to dibutyl phthalate (Dbp) or diethylstilbestrol (des) leads to long-term changes in hypothalamic gene expression and sexual behavior.

The Physiology of Reproduction – Quo vadis? (2021)
Journal Article
Ivell, R., & Anand-Ivell, R. (2021). The Physiology of Reproduction – Quo vadis?. Frontiers in Physiology, 12, Article 650550. https://doi.org/10.3389/fphys.2021.650550

The reproductive system in males and females reflects a highly dynamic underlying physiology. Yet our current understanding of this system is still largely based upon relatively simplistic snapshots of individual component cells and tissues. Gamete p... Read More about The Physiology of Reproduction – Quo vadis?.

Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism (2020)
Journal Article
Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Mills, E., Chia, G., …Dhillo, W. S. (2021). Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism. Neuroendocrinology, 111(12), 1176-1186. https://doi.org/10.1159/000513248

Background: Hypogonadotropic hypogonadism (HH) is hypogonadism due to either hypothalamic or pituitary dysfunction. While gonadotropin-releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Ki... Read More about Kisspeptin-54 Accurately Identifies Hypothalamic Gonadotropin-Releasing Hormone Neuronal Dysfunction in Men with Congenital Hypogonadotropic Hypogonadism.

Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates (2020)
Journal Article
Ivell, R., Alhujaili, W., Kohsaka, T., & Anand-Ivell, R. (2020). Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates. General and Comparative Endocrinology, 299, https://doi.org/10.1016/j.ygcen.2020.113583

© 2020 Elsevier Inc. Although the insulin-like peptide hormone INSL3 and its cognate receptor RXFP2 (relaxin-family peptide receptor 2) have existed throughout chordate evolution, their physiological diversification appears to be linked closely with... Read More about Physiology and evolution of the INSL3/RXFP2 hormone/receptor system in higher vertebrates.

Insulin-Like Peptide 3 (INSL3) (2018)
Book Chapter
Anand-Ivell, R., & Ivell, R. (2018). Insulin-Like Peptide 3 (INSL3). In I. Huhtaniemi, & L. Martini (Eds.), Encyclopedia of Endocrine Diseases (793-806). (Second). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.65735-5

© 2019 Elsevier Inc. Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excell... Read More about Insulin-Like Peptide 3 (INSL3).

Endocrinology of the Fetal Testis (2017)
Book Chapter
Ivell, R., Anand-Ivell, R., & Morley, S. D. (2017). Endocrinology of the Fetal Testis. In M. Simoni, & I. Huhtaniemi (Eds.), Endocrinology of the Testis and Male Reproduction (245-272). Springer. https://doi.org/10.1007/978-3-319-44441-3_7

The human fetus, already at a very early stage in its development, is hormonally active, with the testis and adrenal gland being major contributors. Following sex determination at around weeks 5–6, the somatic cells of the testis begin to differentia... Read More about Endocrinology of the Fetal Testis.

Amniotic fluid phthalate levels and male fetal gonad function (2014)
Journal Article
Jensen, M. S., Anand-Ivell, R., Nørgaard-Pedersen, B., Jönsson, B. A., Bonde, J. P., Hougaard, D. M., …Toft, G. (2015). Amniotic fluid phthalate levels and male fetal gonad function. Epidemiology, 26(1), 91-99. https://doi.org/10.1097/EDE.0000000000000198

Background: Prenatal exposure to phthalates may pose a threat to human male reproduction. However, additional knowledge about the in vivo effect in humans is needed, and reported associations with genital abnormalities are inconclusive. We aimed to s... Read More about Amniotic fluid phthalate levels and male fetal gonad function.

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling (2014)
Journal Article
Barthold, J. S., Robbins, A., Wang, Y., Pugarelli, J., Mateson, A., ANAND-IVELL, R., …Akins, R. E. (2014). Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling. Biology of Reproduction, 91(2), Article 41. https://doi.org/10.1095/biolreprod.114.119560

Human Testicular Insulin-Like Factor 3 and Endocrine Disrupters (2014)
Book Chapter
Bay, K., & Anand-Ivell, R. (2014). Human Testicular Insulin-Like Factor 3 and Endocrine Disrupters. In Endocrine Disrupters (327-348). Elsevier. https://doi.org/10.1016/B978-0-12-800095-3.00012-2

The hormone insulin-like factor 3 (INSL3) is produced by testicular Leydig cells. Production of INSL3 is dependent on the state of Leydig cell differentiation and is stimulated by the long-term trophic effects of luteinizing hormone. INSL3 is, along... Read More about Human Testicular Insulin-Like Factor 3 and Endocrine Disrupters.

Circulating insulin-like factor 3 (INSL3) in healthy and infertile women (2013)
Journal Article
Anand-Ivell, R., Tremellen, K., Dai, Y., Heng, K., Yoshida, M., Knight, P. G., …Ivell, R. (2013). Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human Reproduction, 28(11), 3093-3102. https://doi.org/10.1093/humrep/det349

STUDY QUESTIONHow does insulin-like factor 3 (INSL3) concentration in blood vary across the menstrual cycle in women?SUMMARY ANSWERINSL3 is secreted by the theca interna cells of growing antral follicles and is phasic in its expression.WHAT IS KNOWN... Read More about Circulating insulin-like factor 3 (INSL3) in healthy and infertile women.

Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy (2012)
Journal Article
Jensen, M. S., Norgaard-Pedersen, B., Toft, G., Hougaard, D. M., Bonde, J. P., Cohen, A., …Jönsson, B. A. (2012). Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy. Environmental Health Perspectives, 120(6), 897-903. https://doi.org/10.1289/ehp.1104522

Background: Measures of prenatal environmental exposures are important, and amniotic fluid levels may directly reflect fetal exposures during hypothesized windows of vulnerability. Objectives: We aimed to detect various phthalate metabolites and perf... Read More about Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: Temporal trends and timing of amniocentesis in pregnancy.

The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats (2011)
Journal Article
Heng, K., Anand-Ivell, R., Teerds, K., & Ivell, R. (2012). The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats. International Journal of Andrology, 35(3), 353-363. https://doi.org/10.1111/j.1365-2605.2011.01231.x

The manner by which endocrine-disrupting xenobiotics, such as phthalates, can induce changes in the development of the male reproductive system still remains largely unknown. Herein, we have explored the application of ethane dimethane sulphonate (ED... Read More about The endocrine disruptors dibutyl phthalate (DBP) and diethylstilbestrol (DES) influence Leydig cell regeneration following ethane dimethane sulphonate treatment of adult male rats.

Biological role and clinical significance of insulin-like peptide 3 (2011)
Journal Article
Ivell, R., & Anand-Ivell, R. (2011). Biological role and clinical significance of insulin-like peptide 3. Current Opinion in Endocrinology, Diabetes and Obesity, 18(3), 210-216. https://doi.org/10.1097/MED.0b013e3283453fe6

Purpose of Review: Insulin-like peptide 3 (INSL3) is the subject of a fast expanding literature reflecting increasing clinical application, particularly as a diagnostic parameter. This review summarizes the recent INSL3 literature published within th... Read More about Biological role and clinical significance of insulin-like peptide 3.