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Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study

Ivell, Richard; Vinggaard, Anne Marie; Soyama, Hiroaki; Anand-Ivell, Ravinder

Influence on the adult male Leydig cell biomarker insulin-like peptide 3 of maternal exposure to estrogenic and anti-androgenic endocrine disrupting compound mixtures: A retrospective study Thumbnail


Authors

Richard Ivell

Anne Marie Vinggaard

Hiroaki Soyama



Abstract

Insulin-like peptide 3 (INSL3) is a peptide biomarker secreted specifically by the mature Leydig cells of the testes. It is constitutive, has low within-individual variance, and effectively measures the functional capacity of Leydig cells to make testosterone. In young adult men there is a large 10-fold range of serum INSL3 concentration, persisting into old age, and implying that later hypogonadal status might be programmed in early life. To determine whether maternal exposure to environmental endocrine disrupting compounds (EDCs) influences adult serum INSL3 concentration, using a retrospective paradigm, INSL3 was measured in young adult male rats (80–90 days) from the F1 generation of females maternally exposed to varied doses of bisphenol A (BPA), butylparaben, epoxiconazole, and fludioxonil as single compounds, as well as estrogenic and anti-androgenic mixtures of BPA and butylparaben, and di(2-ethylhexyl) phthalate and procymidone respectively. A mixture of BPA and butylparaben significantly reduced circulating INSL3 concentration in adult male progeny. The remaining compounds or mixtures tested, though sufficient to induce other effects in the F1 generation were without significant effect. Maternal exposure to low concentrations of some EDCs may be a contributing factor to the variation in the Leydig cell biomarker INSL3 in young adulthood, though caution is warranted translating results from rats to humans.

Journal Article Type Article
Acceptance Date Aug 7, 2022
Online Publication Date Aug 19, 2022
Publication Date 2022-12
Deposit Date Nov 7, 2022
Publicly Available Date Nov 8, 2022
Journal Andrologia
Print ISSN 0303-4569
Electronic ISSN 1439-0272
Peer Reviewed Peer Reviewed
Volume 54
Issue 11
Article Number e14566
DOI https://doi.org/10.1111/and.14566
Public URL https://nottingham-repository.worktribe.com/output/10907347
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/and.14566

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