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All Outputs (209)

Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes (2015)
Journal Article
German, S. D., Lee, J.-H., Campbell, K. H., Sweetman, D., & Alberio, R. (in press). Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes. Biology of Reproduction, 92(4), https://doi.org/10.1095/biolreprod.114.122341

Oocytes treated with the protein synthesis inhibitor cycloheximide (CHX) arrest at the germinal vesicle (GV) stage and undergo accelerated GV breakdown (GVBD) after CHX is removed. However, little is known about the underlying mechanism of accelerate... Read More about Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes.

Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning (2015)
Journal Article
Voigt, J. P., Lee, J. L. C., Heath, F. C., Jurkus, R., Bast, T., Pezze, M. A., …Stevenson, C. W. (2015). Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning. Psychopharmacology, 232(14), 2619-2629. https://doi.org/10.1007/s00213-015-3897-y

RATIONALE: Dopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear.

OBJECTIVES: The objective of this study was to inves... Read More about Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning.

Determination of the absolute accuracy of UK chamber facilities used in measuring methane emissions from livestock (2015)
Journal Article
Gardiner, T., Coleman, M., Innocenti, F., Tompkins, J., Connor, A., Garnsworthy, P., …Wills, D. (2015). Determination of the absolute accuracy of UK chamber facilities used in measuring methane emissions from livestock. Measurement, 66, https://doi.org/10.1016/j.measurement.2015.02.029

Respiration chambers are one of the primary sources of data on methane emissions from livestock. This paper describes the results from a coordinated set of chamber validation experiments which establishes the absolute accuracy of the methane emission... Read More about Determination of the absolute accuracy of UK chamber facilities used in measuring methane emissions from livestock.

Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer (2015)
Journal Article
German, S. D., Campbell, K. H., Thornton, E., McLachlan, G., Sweetman, D., & Alberio, R. (2015). Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer. Cellular Reprogramming, 17(1), https://doi.org/10.1089/cell.2014.0071

Induced pluripotent stem cells (iPSCs) share similar characteristics of indefinite in vitro growth with embryonic stem cells (ESCs) and may therefore serve as a useful tool for the targeted genetic modification of farm animals via nuclear transfer (N... Read More about Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer.

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver (2015)
Journal Article
Drake, A. J., O'Shaughnessy, P. J., Bhattachyrya, S., Monteiro, A., Kerrigan, D., Goetz, S., …Fowler, P. A. (2015). In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13, https://doi.org/10.1186/s12916-014-0251-x

Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vita... Read More about In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver.

Developing best practice guidelines on equine colic (2015)
Journal Article
Freeman, S., & Curtis, L. (in press). Developing best practice guidelines on equine colic. Veterinary Record, 176(2), https://doi.org/10.1136/vr.g7688

Sarah Freeman and Laila Curtis describe an ongoing project that is aiming to develop evidence-based, best practice guidelines to help owners and veterinary surgeons recognise the signs of colic in horses. They also report on the first of two multidis... Read More about Developing best practice guidelines on equine colic.

Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls (2014)
Journal Article
Hagen, C. P., Mieritz, M. G., Nielsen, J. E., Anand-Ivell, R., Ivell, R., & Juul, A. (2015). Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls. Fertility and Sterility, 103(3), https://doi.org/10.1016/j.fertnstert.2014.11.014

Objective: To elucidate the natural course of circulating insulin-like peptide 3 (INSL3) levels according to puberty as well as its relation to other reproductive hormones.
Design: Population-based cohort study.
Setting: Not applicable.
Patient(s)... Read More about Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls.

Interactions between FGF18 and retinoic acid regulate differentiation of chick embryo limb myoblasts (2014)
Journal Article
Mok, G. F., Cardenas, R., Anderton, H., Campbell, K. H., & Sweetman, D. (2014). Interactions between FGF18 and retinoic acid regulate differentiation of chick embryo limb myoblasts. Developmental Biology, 396(2), https://doi.org/10.1016/j.ydbio.2014.10.004

During limb development Pax3 positive myoblasts delaminate from the hypaxial dermomyotome of limb level somites and migrate into the limb bud where they form the dorsal and ventral muscle masses. Only then do they begin to differentiate and express m... Read More about Interactions between FGF18 and retinoic acid regulate differentiation of chick embryo limb myoblasts.

The effects of milking frequency in early lactation on milk yield, mammary cell turnover, and secretory activity in grazing dairy cows (2014)
Journal Article
Murney, R., Margerison, J. K., Stelwagen, K., Wheeler, T., & Singh, K. (2015). The effects of milking frequency in early lactation on milk yield, mammary cell turnover, and secretory activity in grazing dairy cows. Journal of Dairy Science, 98(1), 305-311. https://doi.org/10.3168/jds.2014-8745

In dairy cows, short-term changes of milking frequency in early lactation have been shown to produce an immediate and a long-term effect on milk yield in stall-fed cows. The effect is controlled locally within mammary glands and could be a function o... Read More about The effects of milking frequency in early lactation on milk yield, mammary cell turnover, and secretory activity in grazing dairy cows.

Methane emissions among individual dairy cows during milking quantified by eructation peaks or ratio with carbon dioxide (2014)
Journal Article
Bell, M. J., Saunders, N., Wilcox, R., Homer, E., Goodman, J., Craigon, J., & Garnsworthy, P. (2014). Methane emissions among individual dairy cows during milking quantified by eructation peaks or ratio with carbon dioxide. Journal of Dairy Science, 97(10), 6536-6546. https://doi.org/10.3168/jds.2013-7889

The aims of this study were to compare methods for examining measurements of CH4 and CO2 emissions of dairy cows during milking and to assess repeatability and variation of CH4 emissions among individual dairy cows. Measurements of CH4 and CO2 emissi... Read More about Methane emissions among individual dairy cows during milking quantified by eructation peaks or ratio with carbon dioxide.

Variation in composition of pre-grazed pasture herbage in the United Kingdom, 2006-2012 (2014)
Journal Article
Wilkinson, J. M., Allen, J. D., Tunnicliffe, R., Smith, M., & Garnsworthy, P. C. (2014). Variation in composition of pre-grazed pasture herbage in the United Kingdom, 2006-2012. Animal Feed Science and Technology, 196, 139-144. https://doi.org/10.1016/j.anifeedsci.2014.07.001

A total of 8814 samples of pre-grazed herbage samples was analysed by near infrared spectroscopy calibrated against wet chemistry between March 2006 and October 2012. There were decreasing trends over the seven-year period in annual mean crude protei... Read More about Variation in composition of pre-grazed pasture herbage in the United Kingdom, 2006-2012.

Evaluation of normal findings using a detailed and focused technique for transcutaneous abdominal ultrasonography in the horse (2014)
Journal Article
Williams, S., Cooper, J. D., & Freeman, S. (2014). Evaluation of normal findings using a detailed and focused technique for transcutaneous abdominal ultrasonography in the horse. BMC Veterinary Research, 10(Suppl), Article S5. https://doi.org/10.1186/1746-6148-10-S1-S5

Background

Ultrasonography is an important diagnostic tool in the investigation of abdominal disease in the horse. Several factors may affect the ability to image different structures within the abdomen. The aim of the study was to describe the re... Read More about Evaluation of normal findings using a detailed and focused technique for transcutaneous abdominal ultrasonography in the horse.

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling (2014)
Journal Article
Barthold, J. S., Robbins, A., Wang, Y., Pugarelli, J., Mateson, A., Anand-Ivell, R., …Akins, R. E. J. (2014). Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling. Biology of Reproduction, 91(2), https://doi.org/10.1095/biolreprod.114.119560

Cryptorchidism, or undescended testis, is a common male genital anomaly of unclear etiology. Hormonal stimulation of the developing fetal gubernaculum by testicular androgens and insulin-like 3 (INSL3) is required for testicular descent. In studies o... Read More about Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling.

Variation in enteric methane emissions among cows on commercial dairy farms (2014)
Journal Article
Bell, M., Potterton, S., Craigon, J., Saunders, N., Wilcox, R., Hunter, M., …Garnsworthy, P. (2014). Variation in enteric methane emissions among cows on commercial dairy farms. Animal, 8(9), 1540-1546. https://doi.org/10.1017/S1751731114001530

Methane (CH4) emissions by dairy cows vary with feed intake and diet composition. Even when fed on the same diet at the same intake, however, variation between cows in CH4 emissions can be substantial. The extent of variation in CH4 emissions among d... Read More about Variation in enteric methane emissions among cows on commercial dairy farms.

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice (2014)
Journal Article
Watkins, A. J., & Sinclair, K. D. (2014). Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice. AJP - Heart and Circulatory Physiology, 306(10), Article H1444-H1452. https://doi.org/10.1152/ajpheart.00981.2013

Whilst the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal nutrition at the time of conception on offspring phenotype remains poorly defined. Therefore,... Read More about Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice.

Water intake, faecal output and intestinal motility in horses moved from pasture to a stabled management regime with controlled exercise (2014)
Journal Article
Williams, S., Horner, J., Orton, E., Green, M. J., McMullen, S., Mobasheri, A., & Freeman, S. (2014). Water intake, faecal output and intestinal motility in horses moved from pasture to a stabled management regime with controlled exercise. Equine Veterinary Journal, 47(1), https://doi.org/10.1111/evj.12238

Reasons for performing study: A change in management from pasture to stabling is a risk factor for equine colic.

Objectives: To investigate the effect of a management change from pasture with no controlled exercise to stabling with light exercise... Read More about Water intake, faecal output and intestinal motility in horses moved from pasture to a stabled management regime with controlled exercise.

Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females (2014)
Journal Article
Fenton, G., Pollard, A. K., Halliday, D., Mason, R., Bredy, T. W., & Stevenson, C. W. (2014). Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females. Learning and Memory, 21(2), https://doi.org/10.1101/lm.033514.113

Anxiety disorders, such as post-traumatic stress, are more prevalent in women and are characterized by impaired inhibition of learned fear and medial prefrontal cortex (mPFC) dysfunction. Here we examined sex differences in fear extinction and mPFC a... Read More about Persistent prelimbic cortex activity contributes to enhanced learned fear expression in females.

Insulin-like factor 3 and the HPG axis in the male (2014)
Journal Article
Ivell, R., Heng, K., & Anand-Ivell, R. (in press). Insulin-like factor 3 and the HPG axis in the male. Frontiers in Endocrinology, 5(6), https://doi.org/10.3389/fendo.2014.00006

The hypothalamic–pituitary–gonadal (HPG) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation. These in turn stimulate receptors on testicular... Read More about Insulin-like factor 3 and the HPG axis in the male.

Medial prefrontal cortex circuit function during retrieval and extinction of associative learning under anesthesia (2014)
Journal Article
Fenton, G., Halliday, D., Mason, R., & Stevenson, C. W. (2014). Medial prefrontal cortex circuit function during retrieval and extinction of associative learning under anesthesia. Neuroscience, 265, https://doi.org/10.1016/j.neuroscience.2014.01.028

Associative learning is encoded under anesthesia and involves the medial prefrontal cortex (mPFC). Neuronal activity in mPFC increases in response to a conditioned stimulus (CS+) previously paired with an unconditioned stimulus (US) but not during pr... Read More about Medial prefrontal cortex circuit function during retrieval and extinction of associative learning under anesthesia.