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Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning

Voigt, J. Peter; Lee, Jonathan L. C.; Heath, Florence C.; Jurkus, Regimantas; Bast, Tobias; Pezze, Marie A.; Lee, Jonathan L.C.; Voigt, Jörg-Peter; Stevenson, Carl W.

Authors

J. Peter Voigt

Jonathan L. C. Lee

Florence C. Heath

Regimantas Jurkus

Marie A. Pezze

Jonathan L.C. Lee

Jörg-Peter Voigt



Abstract

RATIONALE: Dopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear.

OBJECTIVES: The objective of this study was to investigate (1) the effects of SCH 23390, a dopamine D1/D5 receptor antagonist, on contextual fear memory encoding, retrieval and reconsolidation, and (2) if the effects of SCH 23390 on conditioning involve the dorsal hippocampus (DH) and/or basolateral amygdala (BLA).

METHODS: Rats were used to examine the effects of systemically administering SCH 23390 on the acquisition, consolidation, retrieval and reconsolidation of contextual fear memory, and on locomotor activity and shock sensitivity. We also determined the effects of MK-801, an NMDA receptor antagonist, on contextual fear memory reconsolidation. The effects of infusing SCH 23390 locally into DH or BLA on contextual fear conditioning and locomotor activity were also examined.

RESULTS: Systemic administration of SCH 23390 impaired contextual fear conditioning but had no effects on fear memory consolidation, retrieval or reconsolidation. MK-801 was found to impair reconsolidation, suggesting that the behavioural parameters used allowed for the pharmacological disruption of memory reconsolidation. The effects of SCH 23390 on conditioning were unlikely the result of any lasting drug effects on locomotor activity at memory test or any acute drug effects on shock sensitivity during conditioning. SCH 23390 infused into either DH or BLA impaired contextual fear conditioning and decreased locomotor activity.

CONCLUSIONS: These findings suggest that dopamine D1-like receptor signalling in DH and BLA contributes to the acquisition of contextual fear memory.

Journal Article Type Article
Publication Date 2015-07
Journal Psychopharmacology
Print ISSN 0033-3158
Electronic ISSN 1432-2072
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 232
Issue 14
Pages 2619-2629
APA6 Citation Voigt, J. P., Lee, J. L. C., Heath, F. C., Jurkus, R., Bast, T., Pezze, M. A., …Stevenson, C. W. (2015). Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning. Psychopharmacology, 232(14), 2619-2629. https://doi.org/10.1007/s00213-015-3897-y
DOI https://doi.org/10.1007/s00213-015-3897-y
Keywords Pharmacology
Publisher URL http://link.springer.com/article/10.1007%2Fs00213-015-3897-y
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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