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Variability in Enteric Methane Emissions among Dairy Cows during Lactation (2022)
Journal Article
Hardan, A., Garnsworthy, P. C., & Bell, M. J. (2022). Variability in Enteric Methane Emissions among Dairy Cows during Lactation. Animals, 13(1), Article 157. https://doi.org/10.3390/ani13010157

The aim of this study was to investigate variability in enteric CH4 emission rate and emissions per unit of milk across lactations among dairy cows on commercial farms in the UK. A total of 105,701 CH4 spot measurements were obtained from 2206 mostly... Read More about Variability in Enteric Methane Emissions among Dairy Cows during Lactation.

Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner (2022)
Journal Article
Thangaraj, S. V., Kachman, M., Halloran, K. M., Sinclair, K. D., Lea, R., Bellingham, M., …Padmanabhan, V. (2023). Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner. Science of the Total Environment, 864, Article 161054. https://doi.org/10.1016/j.scitotenv.2022.161054

Background Everyday, humans are exposed to a mixture of environmental chemicals some of which have endocrine and/or metabolism disrupting actions which may contribute to non-communicable diseases. The adverse health impacts of real-world chemical ex... Read More about Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner.

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Warren, W. G., Papagianni, E. P., Hale, E., Brociek, R. A., Cassaday, H. J., & Stevenson, C. W. (2022). Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in Pharmacology, 13, Article 1082760. https://doi.org/10.3389/fphar.2022.1082760

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants (2022)
Journal Article
Stöger, R., Choi, M., Begum, K., Leeman, G., Emes, R. D., Melamed, P., & Bentley, G. R. (2023). Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants. Epigenetics, 18(1), Article 2153511. https://doi.org/10.1080/15592294.2022.2153511

Migration from one location to another often comes with a change in environmental conditions. Here, we analysed features of DNA methylation in young, adult British-Bangladeshi women who experienced different environments during their childhoods: a) m... Read More about Childhood environment influences epigenetic age and methylation concordance of a CpG clock locus in British-Bangladeshi migrants.

Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes (2022)
Journal Article
White, K., Aldurdunji, M., Harris, J., Ortori, C., & Paine, S. (2022). Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes. Pharmacology Research and Perspectives, 10(6), Article e01031. https://doi.org/10.1002/prp2.1031

The translation of new injectable anaesthetic drugs from rodent to humans remains slow, despite the realisation that reliance on the volatile agents is unsustainable from an environmental perspective. The aim of this study was to investigate the infl... Read More about Alfaxalone population pharmacokinetics in the rat: Model application for pharmacokinetic and pharmacodynamic design in inbred and outbred strains and sexes.

Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii (2022)
Journal Article
Fakae, L. B., Harun, M. S., Ting, D. S. J., Dua, H. S., Cave, G. W., Zhu, X. Q., …Elsheikha, H. M. (2023). Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii. Acta Tropica, 237, Article 106729. https://doi.org/10.1016/j.actatropica.2022.106729

We examined the anti-acanthamoebic efficacy of green tea Camellia sinensis solvent extract (SE) or its chemical constituents against Acanthamoeba castellanii by using anti-trophozoite, anti-encystation, and anti-excystation assays. C. sinensis SE (62... Read More about Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Papagianni, E. P., Warren, W. G., Cassaday, H. J., & Stevenson, C. W. (2022). Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance. International Journal of Molecular Sciences, 23(16), Article 9333. https://doi.org/10.3390/ijms23169333

Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.

URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
Warren, W. G., Hale, E., Papagianni, E. P., Cassaday, H. J., Stevenson, C. W., & Stubbendorff, C. (2022). URB597 induces subtle changes to aggression in adult Lister Hooded rats. Frontiers in Psychiatry, 13, Article 885146. https://doi.org/10.3389/fpsyt.2022.885146

The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.

Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis (2022)
Journal Article
Bougouin, A., Hristov, A., Dijkstra, J., Aguerre, M. J., Ahvenjärvi, S., Arndt, C., …Kebreab, E. (2022). Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis. Journal of Dairy Science, 105(9), 7462-7481. https://doi.org/10.3168/jds.2021-20885

Manure nitrogen (N) from cattle contributes to nitrous oxide and ammonia emissions and nitrate leaching. Measurement of manure N outputs on dairy farms is laborious, expensive, and impractical at large scales; therefore, models are needed to predict... Read More about Prediction of nitrogen excretion from data on dairy cows fed a wide range of diets compiled in an intercontinental database: A meta-analysis.

Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva (2022)
Journal Article
Jenkins, H. H., Lopez, A. A. T., Tarantini, F. S., Tomlin, H., Scales, D., Lee, I., …Seedhouse, C. (2022). Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva. Scientific Reports, 12(1), Article 11553. https://doi.org/10.1038/s41598-022-15616-6

Polymerase chain reaction (PCR) has proven to be the gold-standard for SARS-CoV-2 detection in clinical settings. The most common approaches rely on nasopharyngeal specimens obtained from swabs, followed by RNA extraction, reverse transcription and q... Read More about Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva.

Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs (2022)
Journal Article
Elcombe, C. S., Monteiro, A., Elcombe, M. R., Ghasemzadeh-Hasankolaei, M., Sinclair, K. D., Lea, R., …Bellingham, M. (2022). Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs. Environmental Toxicology and Pharmacology, 94, Article 103913. https://doi.org/10.1016/j.etap.2022.103913

Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationa... Read More about Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.

Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos (2022)
Journal Article
Silvestri, G., Turner, K. J., Silcock, J. L., Sinclair, K. D., & Griffin, D. K. (2022). Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos. The European Zoological Journal, 89(1), 680-689. https://doi.org/10.1080/24750263.2022.2077994

Embryo splitting can be used in cattle in vitro production (IVP) to improve embryo availability and to increase selection intensity. Despite this widespread utility, a comparative investigation of the viability of IVP embryos split at Day 2 (2-cell s... Read More about Effects of single or serial embryo splitting on the development and morphokinetics of in vitro produced bovine embryos.

Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing (2022)
Journal Article
Rubini, E., Schenkelaars, N., Rousian, M., Sinclair, K. D., Wekema, L., Faas, M. M., …Schoenmakers, S. (2022). Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing. American Journal of Obstetrics and Gynecology, 227(3), 392-400. https://doi.org/10.1016/j.ajog.2022.04.013

A healthy diet prior to and during pregnancy is beneficial in acquiring essential B vitamins involved in one-carbon metabolism, and to maintain a healthy gut microbiota. Each play important roles in fetal development, immune-system remodeling and pre... Read More about Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing.

Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle (2022)
Journal Article
Negussie, E., González-Recio, O., Battagin, M., Bayat, A., Boland, T., de Haas, Y., …Biscarini, F. (2022). Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle. Journal of Dairy Science, 105(6), 5124-5140. https://doi.org/10.3168/jds.2021-20158

Direct measurements of methane (CH4) from individual animals are difficult and expensive. Predictions based on proxies for CH4 are a viable alternative. Most prediction models are based on multiple linear regressions (MLR) and predictor variables tha... Read More about Integrating heterogeneous across-country data for proxy-based random forest prediction of enteric methane in dairy cattle.

In vitro culture of ovine embryos up to early gastrulating stages (2022)
Journal Article
Ramos-Ibeas, P., González-Brusi, L., Used, M. T., Cocero, M. J., Marigorta, P., Alberio, R., & Bermejo-Álvarez, P. (2022). In vitro culture of ovine embryos up to early gastrulating stages. Development, 149(6), Article dev199743. https://doi.org/10.1242/dev.199743

Developmental failures occurring shortly after blastocyst hatching from the zona pellucida constitute a major cause of pregnancy losses in both humans and farm ungulates. The developmental events occurring following hatching in ungulates include the... Read More about In vitro culture of ovine embryos up to early gastrulating stages.

Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures (2022)
Journal Article
Lea, R. G., Mandon-Pépin, B., Loup, B., Poumerol, E., Jouneau, L., Egbowon, B. F., …Sinclair, K. D. (2022). Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures. Reproduction, 163(2), 119-131. https://doi.org/10.1530/REP-21-0235

Exposure of the fetal testis to numerous individual environmental chemicals (ECs) is frequently associated with dysregulated development, leading to impaired adult reproductive competence. However, 'real-life' exposure involves complex mixtures of EC... Read More about Ovine fetal testis stage-specific sensitivity to environmental chemical mixtures.

Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial (2022)
Journal Article
Joy, E. J., Kalimbira, A. A., Sturgess, J., Banda, L., Chiutsi-Phiri, G., Manase, H., …Allen, E. (2022). Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial. Frontiers in Nutrition, 8, Article 788096. https://doi.org/10.3389/fnut.2021.788096

Background: Selenium deficiency is widespread in the Malawi population. The selenium concentration in maize, the staple food crop of Malawi, can be increased by applying selenium-enriched fertilizers. It is unknown whether this strategy, called agron... Read More about Biofortified Maize Improves Selenium Status of Women and Children in a Rural Community in Malawi: Results of the Addressing Hidden Hunger With Agronomy Randomized Controlled Trial.

Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation (2022)
Journal Article
Wainwright, J., Millar, K. M., & White, G. A. (2022). Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13469

Objectives: To investigate owners’ views around canine nutrition and wellbeing, how these beliefs may differ according to the weight status of the dog and the implications for owner support approaches. Materials and Methods: A researcher-mediated que... Read More about Owners’ views of canine nutrition, weight and wellbeing and their implications for the veterinary consultation.