All Outputs (5)

Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species (2021)
Journal Article
Kinoshita, M., Kobayashi, T., Planells, B., Klisch, D., Spindlow, D., Masaki, H., …Smith, A. (2021). Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development, 148(23), Article dev199901. https://doi.org/10.1242/dev.199901

Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em... Read More about Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species.

Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells? (2021)
Journal Article
Savage, A. M., Alberio, R., & Johnson, A. D. (2021). Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?. Biology Open, 10(10), Article bio058890. https://doi.org/10.1242/bio.058890

In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One possible cause of... Read More about Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Nuclear transfer and the development of genetically modified/gene edited livestock (2021)
Journal Article
Alberio, R., & Wolf, E. (2021). Nuclear transfer and the development of genetically modified/gene edited livestock. Reproduction, 162(1), F59-F68. https://doi.org/10.1530/REP-21-0078

The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells. This ground-breaking ex... Read More about Nuclear transfer and the development of genetically modified/gene edited livestock.

Conserved features of non-primate bilaminar disc embryos and the germline (2021)
Journal Article
Alberio, R., Kobayashi, T., & Surani, M. A. (2021). Conserved features of non-primate bilaminar disc embryos and the germline. Stem Cell Reports, 16(5), 1078-1092. https://doi.org/10.1016/j.stemcr.2021.03.011

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar d... Read More about Conserved features of non-primate bilaminar disc embryos and the germline.