RAMIRO ALBERIO ramiro.alberio@nottingham.ac.uk
Professor of Developmental Biology
Conserved features of non-primate bilaminar disc embryos and the germline
Alberio, Ramiro; Kobayashi, Toshihiro; Surani, M. Azim
Authors
Toshihiro Kobayashi
M. Azim Surani
Abstract
Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar discs offer exceptional opportunities for advances in gastrulation, the germline, and the basis for evolutionary divergence applicable to human development. Here, we discuss the advantages of investigations in the pig embryo as an exemplar of development of a bilaminar disc embryo with relevance to early human development. Besides, the pig has the potential for the creation of humanized organs for xenotransplantation. Precise genetic engineering approaches, imaging, and single-cell analysis are cost effective and efficient, enabling research into some outstanding questions on human development and for developing authentic models of early human development with stem cells.
Citation
Alberio, R., Kobayashi, T., & Surani, M. A. (2021). Conserved features of non-primate bilaminar disc embryos and the germline. Stem Cell Reports, 16(5), 1078-1092. https://doi.org/10.1016/j.stemcr.2021.03.011
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 12, 2021 |
Online Publication Date | May 11, 2021 |
Publication Date | May 11, 2021 |
Deposit Date | Jun 10, 2021 |
Publicly Available Date | Mar 29, 2024 |
Journal | Stem Cell Reports |
Publisher | Cell Press |
Peer Reviewed | Peer Reviewed |
Volume | 16 |
Issue | 5 |
Pages | 1078-1092 |
DOI | https://doi.org/10.1016/j.stemcr.2021.03.011 |
Keywords | Developmental Biology; Genetics; Cell Biology; Biochemistry |
Public URL | https://nottingham-repository.worktribe.com/output/5536147 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S2213671121001417 |
Additional Information | This article is maintained by: Elsevier; Article Title: Conserved features of non-primate bilaminar disc embryos and the germline; Journal Title: Stem Cell Reports; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.stemcr.2021.03.011; Content Type: article; Copyright: © 2021 The Author(s). |
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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