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Conserved features of non-primate bilaminar disc embryos and the germline

Alberio, Ramiro; Kobayashi, Toshihiro; Surani, M. Azim

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Authors

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RAMIRO ALBERIO ramiro.alberio@nottingham.ac.uk
Professor of Developmental Biology

Toshihiro Kobayashi

M. Azim Surani



Abstract

Post-implantation embryo development commences with a bilaminar disc in most mammals, including humans. Whereas access to early human embryos is limited and subject to greater ethical scrutiny, studies on non-primate embryos developing as bilaminar discs offer exceptional opportunities for advances in gastrulation, the germline, and the basis for evolutionary divergence applicable to human development. Here, we discuss the advantages of investigations in the pig embryo as an exemplar of development of a bilaminar disc embryo with relevance to early human development. Besides, the pig has the potential for the creation of humanized organs for xenotransplantation. Precise genetic engineering approaches, imaging, and single-cell analysis are cost effective and efficient, enabling research into some outstanding questions on human development and for developing authentic models of early human development with stem cells.

Citation

Alberio, R., Kobayashi, T., & Surani, M. A. (2021). Conserved features of non-primate bilaminar disc embryos and the germline. Stem Cell Reports, 16(5), 1078-1092. https://doi.org/10.1016/j.stemcr.2021.03.011

Journal Article Type Article
Acceptance Date Mar 12, 2021
Online Publication Date May 11, 2021
Publication Date May 11, 2021
Deposit Date Jun 10, 2021
Publicly Available Date Mar 29, 2024
Journal Stem Cell Reports
Publisher Cell Press
Peer Reviewed Peer Reviewed
Volume 16
Issue 5
Pages 1078-1092
DOI https://doi.org/10.1016/j.stemcr.2021.03.011
Keywords Developmental Biology; Genetics; Cell Biology; Biochemistry
Public URL https://nottingham-repository.worktribe.com/output/5536147
Publisher URL https://www.sciencedirect.com/science/article/pii/S2213671121001417
Additional Information This article is maintained by: Elsevier; Article Title: Conserved features of non-primate bilaminar disc embryos and the germline; Journal Title: Stem Cell Reports; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.stemcr.2021.03.011; Content Type: article; Copyright: © 2021 The Author(s).

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