All Outputs (5)

Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly (2018)
Journal Article
Al-Dabbagh, S., McPhee, J. S., Piasecki, M., Stewart, C. E., & Al-Shanti, N. (2019). Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A, 74(9), 1375–1385. https://doi.org/10.1093/gerona/gly238

The key objective of this work was to investigate the impact of young and old human lymphocyte secretomes on C2C12 myoblasts regeneration. Conditioned media (CMs) were harvested from isolated young and older lymphocytes treated with (activated AC), o... Read More about Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly.

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia (2018)
Journal Article
McPhee, J. S., Cameron, J., Maden-Wilkinson, T., Piasecki, M., Yap, M. H., Jones, D. A., & Degens, H. (2018). The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia. Journals of Gerontology, Series A, 73(10), 1287-1294. https://doi.org/10.1093/gerona/gly040

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia remain unclear. To investigate, 40 older (20 women; age 72 ± 4 years) and 31 younger adults (15 women, age 22 ± 3 years) comple... Read More about The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia.

The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners (2018)
Journal Article
Piasecki, J., Ireland, A., Piasecki, M., Cameron, J., McPhee, J. S., & Degens, H. (2018). The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners. Scandinavian Journal of Medicine and Science in Sports, 28(5), 1559-1568. doi:10.1111/sms.13062

Regular intense endurance exercise can lead to amenorrhea with possible adverse consequences for bone health. We compared whole body and regional bone strength and skeletal muscle characteristics between amenorrheic (AA: n = 14) and eumenorrheic (EA:... Read More about The strength of weight-bearing bones is similar in amenorrheic and eumenorrheic elite long-distance runners.

The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles (2018)
Journal Article
Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D., McPhee, J., & Jones, D. (2018). The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles. European Journal of Applied Physiology, 118(4), 767-775. https://doi.org/10.1007/s00421-018-3811-5

Purpose Current methods for estimating muscle motor unit (MU) number provide values which are remarkably similar for muscles of widely differing size, probably because surface electrodes sample from similar and relatively small volumes in each mus... Read More about The reliability of methods to estimate the number and size of human motor units and their use with large limb muscles.

Age-dependent motor unit remodelling in human limb muscles (2015)
Journal Article
Piasecki, M., Ireland, A., Jones, D. A., & McPhee, J. S. (2016). Age-dependent motor unit remodelling in human limb muscles. Biogerontology, 17(3), 485-496. https://doi.org/10.1007/s10522-015-9627-3

Voluntary control of skeletal muscle enables humans to interact with and manipulate the environment. Lower muscle mass, weakness and poor coordination are common complaints in older age and reduce physical capabilities. Attention has focused on ways... Read More about Age-dependent motor unit remodelling in human limb muscles.