All Outputs (68)

Base flipping in Tn10 transposition: an active flip and capture mechanism (2009)
Journal Article
Bischerour, J., & Chalmers, R. (2009). Base flipping in Tn10 transposition: an active flip and capture mechanism. PLoS ONE, 4(7), Article e6201. https://doi.org/10.1371/journal.pone.0006201

The bacterial Tn5 and Tn10 transposases have a single active site that cuts both strands of DNA at their respective transposon ends. This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction. In Tn... Read More about Base flipping in Tn10 transposition: an active flip and capture mechanism.

Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis (2008)
Journal Article
Zachariou, M., Dissanayake, D. W. N., Coombes, S., Owen, M. R., & Mason, R. (in press). Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2, https://doi.org/10.1007/s11571-008-9050-4

Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific... Read More about Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis.

Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells (2007)
Journal Article
van Leeuwen, I. M. M., Byrne, H. M., Jensen, O. E., & King, J. R. (2007). Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells. Journal of Theoretical Biology, 247(1), 77-102. https://doi.org/10.1016/j.jtbi.2007.01.019

Wnt signalling is involved in a wide range of physiological and pathological processes. The presence of an extracellular Wnt stimulus induces cytoplasmic stabilisation and nuclear translocation of beta-catenin, a protein that also plays an essential... Read More about Elucidating the interactions between the adhesive and transcriptioanl functions of beta-catenin in normal and cancerous cells.

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain (2006)
Journal Article
Jhaveri, M., Richardson, D., Kendall, D., Barrett, D., & Chapman, V. (2006). Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain

Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states. The aim of... Read More about Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain.

The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study (2006)
Journal Article
Zachariou, M., Dissanayake, D., Owen, M. R., Mason, R., & Coombes, S. The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study. Neurocomputing, 70(10/12), https://doi.org/10.1016/j.neucom.2006.10.065

Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects. Auditory gating is perturbed in schizophrenic patients and... Read More about The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study.

Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event
Journal Article
Kay, C. J., Lawler, K., & Kerr, I. D. Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event. Bioscience Reports, 33(6), Article e00084. https://doi.org/10.1042/BSR20130049

As free-living organisms the ancestors of mitochondria and plastids encoded complete genomes, proteomes and metabolomes. As these symbionts became organelles all these aspects were reduced – genomes have degenerated with the host nucleus now encoding... Read More about Analysis of the Sam50 translocase of excavate organisms supports evolution of divergent organelles from a common endosymbiotic event.

Delivery and use of individualised feedback in large class medical teaching
Journal Article
Burr, S. A., Brodier, E., & Wilkinson, S. Delivery and use of individualised feedback in large class medical teaching. BMC Medical Education, 13(May), Article 7. https://doi.org/10.1186/1472-6920-13-63

Background: Formative feedback that encourages self-directed learning in large class medical teaching is difficult to deliver. This study describes a new method, blueprinted feedback, and explores learner’s responses to assess its appropriate use w... Read More about Delivery and use of individualised feedback in large class medical teaching.

Recombinant expression of Aryl Hydrocarbon Receptor for quantitative ligand-binding analysis
Journal Article
Fan, M., Bell, A. R., Bell, D. R., Clode, S., Fernandes, A., Foster, P. M., …White, S. Recombinant expression of Aryl Hydrocarbon Receptor for quantitative ligand-binding analysis. Analytical Biochemistry, 384, https://doi.org/10.1016/j.ab.2008.10.003

Recombinant expression of the Aryl Hydrocarbon Receptor (AhR) yields small amounts of ligand- binding competent AhR. Therefore, Spodoptera frugiperda (Sf9) cells and baculovirus have been evaluated for high level and functional expression of AhR. R... Read More about Recombinant expression of Aryl Hydrocarbon Receptor for quantitative ligand-binding analysis.