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Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis

Zachariou, Margarita; Dissanayake, Dilshani W N; Coombes, Stephen; Owen, Markus R.; Mason, Robert

Authors

Margarita Zachariou pmxmz@nottingham.ac.uk

Dilshani W N Dissanayake dilshani2003@yahoo.co.uk

Markus R. Owen Markus.Owen@nottingham.ac.uk

Robert Mason Rob.Mason@nottingham.ac.uk

Abstract

Gating of sensory information can be assessed using an auditory conditioning-test paradigm which measures the reduction in the auditory evoked response to a test stimulus following an initial conditioning stimulus. Recording brainwaves from specific areas of the brain using multiple electrodes is helpful in the study of the neurobiology of sensory gating. In this paper, we use such technology to investigate the role of cannabinoids in sensory gating in the CA3 region of the rat hippocampus. Our experimental results show that application of the exogenous cannabinoid agonist WIN55,212-2 can abolish sensory gating. We have developed a phenomenological model of cannabinoid dynamics incorporated within a spiking neural network model of CA3 with synaptically interacting pyramidal and basket cells. Direct numerical simulations of this model suggest that
the basic mechanism for this effect can be traced to the suppression of inhibition of slow GABAB synapses. Furthermore, by working with a simpler mathematical firing rate model we are able to show the robustness of this mechanism for the abolition of sensory gating.

Journal Article Type Article
Journal Cognitive Neurodynamics
Print ISSN 1871-4080
Electronic ISSN 1871-4099
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 2
Institution Citation Zachariou, M., Dissanayake, D. W. N., Coombes, S., Owen, M. R., & Mason, R. (in press). Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis. Cognitive Neurodynamics, 2, doi:10.1007/s11571-008-9050-4
DOI https://doi.org/10.1007/s11571-008-9050-4
Keywords sensory gating, cannabinoids, GABAB, firing rate models
Publisher URL https://link.springer.com/article/10.1007%2Fs11571-008-9050-4
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0




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