All Outputs (6)

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis (2023)
Journal Article
Mózes, F. E., Lee, J. A., Vali, Y., Alzoubi, O., Staufer, K., Trauner, M., …Hytiroglou, P. (2023). Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis. Lancet Gastroenterology and Hepatology, 8(8), 704-713. https://doi.org/10.1016/S2468-1253%2823%2900141-3

Background Histologically assessed liver fibrosis stage has prognostic significance in patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate endpoint in clinical trials for non-cirrhotic NAFLD. Our aim was to compare... Read More about Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis.

Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression (2022)
Journal Article
Bradley, C. R., Cox, E. F., Palaniyappan, N., Aithal, G. P., Francis, S. T., & Guha, I. N. (2022). Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression. European Radiology Experimental, 6(1), Article 52. https://doi.org/10.1186/s41747-022-00303-y

Abstract: Background: We annually monitored stable compensated cirrhosis (CC) patients to evaluate serial variation in blood serum, liver stiffness, and multiparametric magnetic resonance imaging (mpMRI) measures to provide reference change values (R... Read More about Variability of noninvasive MRI and biological markers in compensated cirrhosis: insights for assessing disease progression.

Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients (2018)
Journal Article
Bradley, C., Scott, R., Cox, E., Palaniyappan, N., Thompson, B., Ryder, D., …Francis, S. (2019). Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients. European Radiology, 29(6), 3100–3107. https://doi.org/10.1007/s00330-018-5788-1

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before DAA therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed). Results: We observed changes in... Read More about Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients.

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, Article 26. https://doi.org/10.1186/s41747-018-0056-3

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More about MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis.

Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (in press). Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia. Journal of Magnetic Resonance Imaging, ISSN 1053-1807

Background: Non-invasive assessment of dynamic changes in liver blood flow, perfusion and oxygenation using magnetic resonance imaging (MRI) may allow detection of subtle haemodynamic alterations in cirrhosis. Purpose: To assess the feasibility of... Read More about Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia.

Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study (2018)
Journal Article
Palaniyappan, L., Hodgson, O., Balain, V., Iwabuchi, S., Gowland, P., & Liddle, P. (2019). Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study. Psychological Medicine, 49(3), 412-420. https://doi.org/10.1017/S0033291718001010

Background: In patients with schizophrenia, distributed abnormalities are observed in grey matter volume. A recent hypothesis posits that these distributed changes are indicative of a plastic reorganization process occurring in response to a function... Read More about Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study.