Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia

Cox, Eleanor F.; Palaniyappan, Naveen; Aithal, Guruprasad P.; Guha, I. Neil; Francis, Susan T.

Abstract

Background: Non-invasive assessment of dynamic changes in liver blood flow, perfusion and oxygenation using magnetic resonance imaging (MRI) may allow detection of subtle haemodynamic alterations in cirrhosis.
Purpose: To assess the feasibility of measuring dynamic liver blood flow, perfusion and T2* alterations in response to meal, hypercapnia and hyperoxia challenges.
Study Type: Prospective.
Subjects: 10 Healthy participants (HV) and 10 patients with compensated cirrhosis (CC).
Field Strength/Sequence: 3T. Phase contrast, Arterial Spin Labelling and T2* mapping.
Assessment: Dynamic changes in portal vein and hepatic artery blood flow (using phase contrast MRI), liver perfusion (using Arterial Spin Labelling) and blood oxygenation (T2* mapping) following a meal challenge (660 kcal), hyperoxia (Target PETO2 of 500mmHg) and hypercapnia (Target increase PETCO2 of ~6mmHg).
Statistical tests: Tests between baseline and each challenge were performed using a paired two-tailed t-test (parametric) or Wilcoxon-signed-ranks test (non-parametric). Repeatability and reproducibility were determined by the Coefficient of Variation (CoV).
Portal vein velocity increased following the meal (70±9%, p

Citation

Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (in press). Using MRI to study the alterations in liver blood flow, perfusion and oxygenation in response to physiological stress challenges: meal, hyperoxia and hypercapnia. Journal of Magnetic Resonance Imaging,

• Journal Article Type: Article
• Acceptance Date: Aug 29, 2018
• Deposit Date: Sep 4, 2018
• Print ISSN: 1053-1807
• Electronic ISSN: 1522-2586
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Public URL: https://nottingham-repository.worktribe.com/output/1058697