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Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships (2023)
Journal Article
Myers, B., Catrambone, F., Allen, S., Hill, P. J., Kovacs, K., & Rawson, F. J. (2023). Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships. Scientific Reports, 13(1), Article 8843. https://doi.org/10.1038/s41598-023-35553-2

Bacterial pilin nanowires are protein complexes, suggested to possess electroactive capabilities forming part of the cells’ bioenergetic programming. Their role is thought to be linked to facilitating electron transfer between cells and the external... Read More about Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships.

Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo (2023)
Journal Article
Zhu, H., Zhu, W., Liu, Y., Gao, T., Zhu, J., Tan, Y., …Xu, S. (2023). Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo. European Journal of Medicinal Chemistry, 257, Article 115529. https://doi.org/10.1016/j.ejmech.2023.115529

A series of novel stilbene-based derivatives were designed and synthesized as tubulin/HDAC dual-target inhibitors. Among forty-three target compounds, compound II-19k not only exhibited considerable antiproliferative activity in the hematological cel... Read More about Synthesis and bioevaluation of novel stilbene-based derivatives as tubulin/HDAC dual-target inhibitors with potent antitumor activities in vitro and in vivo.

Discovery of new imidazotetrazinones with potential to overcome tumor resistance (2023)
Journal Article
Summers, H. S., Lewis, W., Williams, H. E. L., Bradshaw, T. D., Moody, C. J., & Stevens, M. F. G. (2023). Discovery of new imidazotetrazinones with potential to overcome tumor resistance. European Journal of Medicinal Chemistry, 257, Article 115507. https://doi.org/10.1016/j.ejmech.2023.115507

We describe the design, organic synthesis, and characterization, including X-ray crystallography, of a series of novel analogues of the clinically used antitumor agent temozolomide, together with their in vitro biological evaluation. The work has res... Read More about Discovery of new imidazotetrazinones with potential to overcome tumor resistance.

Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation (2023)
Journal Article
Feng, Z., Cheng, Y., Khlyustova, A., Wani, A., Franklin, T., Varner, J. D., …Yang, R. (2023). Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation. Advanced Materials Technologies, 8(13), Article 2201533. https://doi.org/10.1002/admt.202201533

Amphiphilic copolymers (AP) represent a class of novel antibiofouling materials whose chemistry and composition can be tuned to optimize their performance. However, the enormous chemistry-composition design space associated with AP makes their perfor... Read More about Virtual High‐Throughput Screening of Vapor‐Deposited Amphiphilic Polymers for Inhibiting Biofilm Formation.

Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes (2023)
Journal Article
Lay, C. S., Isidro-Llobet, A., Kilpatrick, L. E., Craggs, P. D., & Hill, S. J. (2023). Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes. Nature Communications, 14, Article 2882. https://doi.org/10.1038/s41467-023-38541-2

Association of single nucleotide polymorphisms in the IL-23 receptor with several auto-inflammatory diseases, led to the heterodimeric receptor and its cytokine-ligand IL-23, becoming important drug targets. Successful antibody-based therapies direct... Read More about Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes.

Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging (2023)
Journal Article
Mousa, S., Novak, V., Fletcher, R. S., Kelly, G., Garcia, M., Macleod, N., …Rigby, S. P. (2023). Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging. Chemical Engineering Science, 277, Article 118880. https://doi.org/10.1016/j.ces.2023.118880

Catalyst pellet fabrication parameters significantly impact final product performance. Tabletted pellets are complex, hierarchical structures that evolve differently over various levels during subsequent processing. Multi-scale porosimetry and multi-... Read More about Evolution of the pore structure-transport relationship during catalyst reduction and sintering studied by integrated multi-scale porosimetry and multi-modal imaging.

Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility (2023)
Journal Article
Xue, R., Deng, X., Xu, X., Tian, Y., Hasan, A., Mata, A., …Liu, L. (2023). Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomaterials Advances, 151, Article 213471. https://doi.org/10.1016/j.bioadv.2023.213471

The biocompatibility of biomedical materials is vital to their applicability and functionality. However, modifying surfaces for enhanced biocompatibility using traditional surface treatment techniques is challenging. We employed a mineralizing elasti... Read More about Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility.

O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England. British Journal of Surgery, 110(Supplement 3), Article znad101.087. https://doi.org/10.1093/bjs/znad101.087

Introduction Little is known regarding whether opioid prescriptions following colectomy lead to persistent use. We aimed to determine the prevalence of persistent post-discharge opioid use following colectomy, stratified by preadmission opioid exposu... Read More about O087 Predictors of persistent opioid use after discharge following colectomy: a population-based cohort study from England.

O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study (2023)
Journal Article
Baamer, R., Humes, D., Toh, L., Knaggs, R., & Lobo, D. (2023). O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study. British Journal of Surgery, 110(Supplement 3), Article znad101.128. https://doi.org/10.1093/bjs/znad101.128

Introduction Opioid prescribing patterns after discharge following colectomy within a population from England are not well characterised. This study aimed to report changes in opioid prescribing prevalence, formulation choices and opioid analgesics o... Read More about O128 Time trends in opioid prescribing after discharge following colectomy in England: a cross-sectional study.

Development of biocide coated polymers and their antimicrobial efficacy (2023)
Journal Article
Watson, R., Maxwell, M., Dunn, S., Brooks, A., Jiang, L., Hill, H. J., …de Cogan, F. (2023). Development of biocide coated polymers and their antimicrobial efficacy. Nano Select, 4(7), 442-453. https://doi.org/10.1002/nano.202300005

Microbial contamination of plastic surfaces is a significant source of hospital‐acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity of chlorhexidine dist... Read More about Development of biocide coated polymers and their antimicrobial efficacy.

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts (2023)
Journal Article
Jones, S., Ashworth, J. C., Meakin, M., Collier, P., Probert, C., Ritchie, A. A., …Grabowska, A. M. (2023). Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In Vitro Models, 2, 99-111. https://doi.org/10.1007/s44164-023-00048-x

Purpose This 3D in vitro cancer model for propagation of patient-derived cells, using a synthetic self-assembling peptide gel, allows the formation of a fully characterised, tailorable tumour microenvironment. Unlike many existing 3D cancer models,... Read More about Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts.

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate (2023)
Journal Article
Bardelang, P., Murray, E. J., Blower, I., Zandomeneghi, S., Goode, A., Hussain, R., …Bonev, B. B. (2023). Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 11, Article 1113885. https://doi.org/10.3389/fchem.2023.1113885

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP)... Read More about Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate.

Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach (2023)
Journal Article
Bridges, S. J. (2023). Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach. Journal of University Teaching & Learning Practice, 20(4), Article 15. https://doi.org/10.53761/1.20.4.15

Internationalised higher education literature draws attention to the tension between the economic returns of recruiting overseas students and the personal, social and cultural possibilities offered. This paper advances the idea that fostering cosmopo... Read More about Conceptualising, evaluating and supporting the development of cosmopolitan values in internationalised higher education: A capabilities approach.

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease (2023)
Journal Article
Sun, Y., Li, J., A, N., Li, Z., Zhong, W., Chen, L., …Li, X. (2023). Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease. Frontiers in Immunology, 14, Article 1192940. https://doi.org/10.3389/fimmu.2023.1192940

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the path... Read More about Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease.

Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight (2023)
Journal Article
Rengel, A. C., Tran, V., & Toh, L. S. (2023). Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight. Aerospace Medicine and Human Performance, 94(5), 389-395. https://doi.org/10.3357/AMHP.6053.2023

INTRODUCTION: Prolonged exposure to microgravity is associated with a significant reduction in bone density, exposing astronauts to renal calculi in flight and osteoporotic fractures on return to Earth. While physical countermeasures and bisphosphona... Read More about Denosumab as a Pharmacological Countermeasure Against Osteopenia in Long Duration Spaceflight.

OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems (2023)
Journal Article
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., …Wright, A. J. (2023). OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Communications Biology, 6, Article 463. https://doi.org/10.1038/s42003-023-04780-8

Biomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument... Read More about OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems.

Apoptotic cell death in disease—Current understanding of the NCCD 2023 (2023)
Journal Article
Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., …Galluzzi, L. (2023). Apoptotic cell death in disease—Current understanding of the NCCD 2023. Cell Death and Differentiation, 30(5), 1097-1154. https://doi.org/10.1038/s41418-023-01153-w

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this p... Read More about Apoptotic cell death in disease—Current understanding of the NCCD 2023.

Synthetic extracellular matrices with function-encoding peptides (2023)
Journal Article
Ligorio, C., & Mata, A. (2023). Synthetic extracellular matrices with function-encoding peptides. Nature Reviews Bioengineering, 1, 518–536. https://doi.org/10.1038/s44222-023-00055-3

The communication of cells with their surroundings is mostly encoded in the epitopes of structural and signalling proteins present in the extracellular matrix (ECM). These peptide epitopes can be incorporated in biomaterials to serve as function-enco... Read More about Synthetic extracellular matrices with function-encoding peptides.