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Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease

Sun, Yuan; Li, Jinran; A, Nan; Li, Zhaoxing; Zhong, Wenyi; Chen, Long; Liu, Sai; Zhang, Bocheng; Zhu, Zheying; Li, Xinuo

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease Thumbnail


Authors

Yuan Sun

Jinran Li

Nan A

Zhaoxing Li

Wenyi Zhong

Long Chen

Sai Liu

Bocheng Zhang

ZHEYING ZHU Zheying.Zhu@nottingham.ac.uk
Associate Professor in International Pharmacy and Traditional Medicines

Xinuo Li



Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the pathogenesis of AD, currently main therapeutic interventions is limited to symptomatic alleviation. Methylprednisolone (MP), a synthetic glucocorticoid, is recognized for its extensive anti-inflammatory properties. Our study assessed the neuroprotective effect of MP (25 mg/kg) administration to an Aβ1-42-induced AD mouse model. Our findings demonstrate that MP treatment can ameliorate cognitive impairment in Aβ1-42-induced AD mice and suppress microglial activation in the cortex and hippocampus. RNA-Sequencing analysis reveals that MP ultimately rescues cognitive dysfunction through improving the synapse function and inhibiting the immune and inflammatory processes. Our study suggests that MP could be a promising drug alternative for the treatment of AD, either alone or in combination with other existing drugs.

Journal Article Type Article
Acceptance Date Apr 17, 2023
Online Publication Date May 1, 2023
Publication Date 2023
Deposit Date May 6, 2023
Publicly Available Date May 10, 2023
Journal Frontiers in Immunology
Electronic ISSN 1664-3224
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 14
Article Number 1192940
DOI https://doi.org/10.3389/fimmu.2023.1192940
Keywords Alzheimer’s disease, neuroinflammation, methylprednisolone, cognitive function, microglial activation
Public URL https://nottingham-repository.worktribe.com/output/20336244
Publisher URL https://www.frontiersin.org/articles/10.3389/fimmu.2023.1192940/full

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