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Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms? (2014)
Journal Article
O'Callaghan, M., Bay-Richter, C., O’ Tuathaigh, C. M., Heery, D. M., Waddington, J., & Moran, P. M. (2014). Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?. Journal of Psychopharmacology, 28(10), https://doi.org/10.1177/0269881114544774

Whether the dopamine Drd-2 receptor is necessary for the behavioural action of antipsychotic drugs is an important question, as Drd-2 antagonism is responsible for their debilitating motor side effects. Using Drd-2 null mice (Drd2 -/-) it has previou... Read More about Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?.

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction (2014)
Journal Article
Reddy, T. R., Li, C., Guo, X., Fischer, P. M., & Dekker, L. V. (2014). Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction. Bioorganic and Medicinal Chemistry, 22(19), 5378-5391. https://doi.org/10.1016/j.bmc.2014.07.043

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-tr... Read More about Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction.

A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry (2014)
Journal Article
Xia, Y., Barrett, D., Li, G., Ortori, C., Liang, J., Yang, B., & Kuang, H. (2014). A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 100, doi:10.1016/j.jpba.2014.07.024

Triterpene saponins are important bioactive constituents widely distributed in many plants. Saponins present in Caulophyllum (Berberidaceae) have not been fully characterized. In this study, we studied triterpene saponins from Caulophyllum robustum u... Read More about A strategy for characterization of triterpene saponins in Caulophyllum robustum hairy roots by liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry.

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis (2014)
Journal Article
Wong, A., Sagar, D. R., Ortori, C. A., Kendall, D. A., Chapman, V., & Barrett, D. A. (2014). Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis. Journal of Lipid Research, 55(9), 1902-1913. doi:10.1194/jlr.M048694

We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define... Read More about Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Identifying patient-level health and social care costs for older adults discharged from acute medical units in England (2014)
Journal Article
Franklin, M., Berdunov, V., Edmans, J., Conroy, S., Gladman, J. R., Tanajewski, L., …Elliott, R. A. (2014). Identifying patient-level health and social care costs for older adults discharged from acute medical units in England. Age and Ageing, 43(5), https://doi.org/10.1093/ageing/afu073

Background: Acute medical units allow for those who need admission to be correctly identified, and for those who could be managed in ambulatory settings to be discharged. However, readmission rates for older people following discharge from acute medi... Read More about Identifying patient-level health and social care costs for older adults discharged from acute medical units in England.

Assessing the safety features of electronic patient medication record systems used in community pharmacies in England (2014)
Journal Article
Ojeleye, O., Avery, A. J., & Boyd, M. J. (2014). Assessing the safety features of electronic patient medication record systems used in community pharmacies in England. British Journal of Clinical Pharmacology, 78(2), 401-409. https://doi.org/10.1111/bcp.12347

Aims: To evaluate the ability of electronic patient medication record (ePMR) systems used in community pharmacies in England to detect and alert users about clinical hazards, errors and other safety problems. Methods: Between September 2012 and Nove... Read More about Assessing the safety features of electronic patient medication record systems used in community pharmacies in England.

Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components (2014)
Journal Article
Harvey, J., Avery, A. J., Ashcroft, D., Boyd, M., Phipps, D. L., & Barber, N. (2015). Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components. Research in Social and Administrative Pharmacy, 11(2), 216-227. https://doi.org/10.1016/j.sapharm.2014.06.005

Background: Identifying risk is an important facet of a safety practice in an organization. To identify risk, all components within a system of operation should be considered. In clinical safety practice, a team of people, technologies, procedures an... Read More about Exploring safety systems for dispensing in community pharmacies: Focusing on how staff relate to organizational components.

High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites (2014)
Journal Article
Manno, N., Sherratt, S., Boaretto, F., Mejìa Coico, F., Espinoza Camus, C., Jara Campos, C., …Falcone, F. (2014). High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites. Carbohydrate Polymers, 113, 607-614. https://doi.org/10.1016/j.carbpol.2014.07.011

The human genome encodes a gene for an enzymatically active chitinase (CHIT1) located in a single copy on Chromosome 1, which is highly expressed by activated macrophages and in other cells of the innate immune response. Several dysfunctional mutatio... Read More about High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites.

Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease (2014)
Journal Article
Laughton, C., Mazanetz, M., & Fischer, P. (2014). Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease. Molecules, 19(7), 9134-9159. https://doi.org/10.3390/molecules19079134

The pathological characteristics of Alzheimer’s Disease (AD) have been linked to the activity of three particular kinases—Glycogen Synthase Kinase 3β (GSK3β), Cyclin-Dependent Kinase 5 (CDK5) and Extracellular-signal Regulated Kinase 2 (ERK2). As a c... Read More about Investigation of the flexibility of protein kinases implicated in the pathology of Alzheimer's Disease.

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function (2014)
Journal Article
Chen, L., Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., …Cassano, P. A. (2014). Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function. PLoS ONE, 9(7), Article e100776. https://doi.org/10.1371/journal.pone.0100776

Background: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function. Methods: We performed GWAS of the rate of cha... Read More about Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function.

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article
Morris, G., Bridge, J., Eltboli, O., Lewis, M., Knox, A., Aylott, J. W., …Rose, F. R. (2014). Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds. AJP - Lung Cellular and Molecular Physiology, 307(1), Article L38-L47. https://doi.org/10.1152/ajplung.00318.2013

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

High throughput screening for biomaterials discovery (2014)
Journal Article
Algahtani, M. S., Alexander, M., Scurr, D. J., Hook, A. L., Anderson, D. G., Langer, R. S., …Davies, M. C. (2014). High throughput screening for biomaterials discovery. Journal of Controlled Release, 190, 115-126. https://doi.org/10.1016/j.jconrel.2014.06.045

Using microarray technologies thousands of biomedical materials can be screened in a rapid, parallel and cost effective fashion to identify the optimum candidate that fulfils a specific biomedical application. High throughput surface characterization... Read More about High throughput screening for biomaterials discovery.

Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study (2014)
Journal Article
Boardman, H., Fakih, S., Marriott, J. L., Anderson, C., & Hussainy, S. Y. (2014). Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study. BMC Public Health, 14, 1-12. https://doi.org/10.1186/1471-2458-14-662

Background: There has been a recent increase in weight management services available in pharmacies across Australia and England. The aim of this study was to determine the following between women in Victoria and Nottingham: similarities and differenc... Read More about Comparing women pharmacy consumers’ experiences with weight loss treatment in Victoria and Nottingham: a cross-sectional study.

Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide (2014)
Journal Article
Korolkov, V. V., Svatek, S. A., Allen, S., Roberts, C. J., Tendler, S. J., Taniguchi, T., …Beton, P. H. (2014). Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide. Chemical Communications, 50(64), https://doi.org/10.1039/C4CC03720K

A two-dimensional porous network formed from perylene tetracarboxylic diimide (PTCDI) and melamine may be deposited from solution on the surfaces of highly oriented pyrolytic graphite (HOPG), hexagonal boron nitride (hBN) and molybdenum disulphide (... Read More about Bimolecular porous supramolecular networks deposited from solution on layered materials: graphite, boron nitride and molybdenum disulphide.

Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model (2014)
Journal Article
Smith, E., Rose, F., Kanczler, J., Shakesheff, K., Gothard, D., White, L., …Oreffoa, R. (2014). Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model. Acta Biomaterialia, 10(10), 4186-4196. https://doi.org/10.1016/j.actbio.2014.06.011

Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have limited effectiveness. In seeking to address bone regeneration, several tissue engineering strategies have come... Read More about Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model.

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells (2014)
Journal Article
Morris, G., Bridge, J., Brace, L., Knox, A., Aylott, J. W., Brightling, C., …Rose, F. R. (2014). A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells. Biofabrication, 6(3), Article 035014. https://doi.org/10.1088/1758-5082/6/3/035014

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to pro... Read More about A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells.

A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth (2014)
Journal Article
McLaren, J. S., Bayston, R., White, L. J., Cox, H. C., Ashraf, W., Rahman, C. V., …Scammell, B. E. (2014). A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth. eCells and Materials Journal, 27, 332-349. https://doi.org/10.22203/eCM.v027a24

Open fractures are at risk of serious infection and, if infected, require several surgical interventions and courses of systemic antibiotics. We investigated a new injectable formulation that simultaneously hardens in vivo to form a porous scaffold f... Read More about A biodegradable antibiotic-impregnated scaffold to prevent osteomyelitis and encourage new bone growth.