All Outputs (2)

A Practical Catalytic Reductive Amination of Carboxylic Acids (2020)
Journal Article
Stoll, E., Tongue, T., Andrews, K. G., Valette, D., Hirst, D. J., & Denton, R. M. (2020). A Practical Catalytic Reductive Amination of Carboxylic Acids. Chemical Science, 11(35), 9494-9500 . https://doi.org/10.1039/d0sc02271c

We report reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide red... Read More about A Practical Catalytic Reductive Amination of Carboxylic Acids.

Synthesis of 18O-labelled alcohols from unlabelled alcohols (2020)
Journal Article
Beddoe, R. H., Edwards, D. C., Goodman, L., Sneddon, H. F., & Denton, R. M. (2020). Synthesis of 18O-labelled alcohols from unlabelled alcohols. Chemical Communications, 56(48), 6480-6483. https://doi.org/10.1039/d0cc02855j

The synthesis of primary, secondary and tertiary 18O-enriched alcohols from readily available 16O-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ing... Read More about Synthesis of 18O-labelled alcohols from unlabelled alcohols.