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Synthesis of 18O-labelled alcohols from unlabelled alcohols

Beddoe, Rhydian H.; Edwards, Daniel C.; Goodman, Louis; Denton, Ross M.

Authors

Rhydian H. Beddoe

Daniel C. Edwards

Louis Goodman

ROSS DENTON ross.denton@nottingham.ac.uk
Professor of Organic Chemistry



Abstract

The synthesis of primary, secondary and tertiary 18O-enriched alcohols from readily available 16O-alcohols via a Mitsunobu esterification and hydrolysis is described. The method is further exemplified in the labelling of the active pharmaceutical ingredient, dropropizine and is shown to be tolerant of modern, separation friendly Mitsunobu reagents.

Citation

Beddoe, R. H., Edwards, D. C., Goodman, L., Sneddon, H. F., & Denton, R. M. (2020). Synthesis of 18O-labelled alcohols from unlabelled alcohols. Chemical Communications, 56(48), 6480-6483. https://doi.org/10.1039/d0cc02855j

Journal Article Type Article
Acceptance Date May 18, 2020
Online Publication Date May 19, 2020
Publication Date Jun 18, 2020
Deposit Date Aug 20, 2020
Publicly Available Date May 20, 2021
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 56
Issue 48
Pages 6480-6483
DOI https://doi.org/10.1039/d0cc02855j
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Public URL https://nottingham-repository.worktribe.com/output/4542172
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2020/CC/D0CC02855J#!divAbstract
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Rhydian H. Beddoe (ORCID); : Daniel C. Edwards (ORCID); : Helen F. Sneddon (ORCID); : Ross M. Denton (ORCID); : Authors can choose between single-blind and double-blind peer review; : Received 20 April 2020; Accepted 18 May 2020; Accepted Manuscript published 19 May 2020; Advance Article published 26 May 2020