All Outputs (10)

Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain (2011)
Journal Article

Background: The Elk-1 transcription factor is a member of a group of proteins called ternary complex factors, which serve as a paradigm for gene regulation in response to extracellular signals. Its deregulation has been linked to multiple human dise... Read More about Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain.

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA (2011)
Journal Article

A method is described for the detection of certain nucleotide modifications adjacent to the 5' 7-methyl guanosine cap of mRNAs from individual genes. The method quantitatively measures the relative abundance of 2'-O-methyl and N 6.

Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites (2011)
Journal Article

Bacterial nucleoid associated proteins play a variety of roles in genome maintenance and dynamics. Their involvement in genome packaging, DNA replication and transcription are well documented but it is still unclear whether they play any specific rol... Read More about Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites.

Carbon nanotube/titanium dioxide (CNT/TiO2) core-shell nanocomposites with tailored shell thickness, CNT content and photocatalytic/photoelectrocatalytic properties (2011)
Journal Article

Combining carbon nanotubes (CNTs) with TiO2 at the nano-scale level can promote the separation of the electron-hole charges generated upon irradiation. However, charge separation capability depends on the quality of the interfacial contact between CN... Read More about Carbon nanotube/titanium dioxide (CNT/TiO2) core-shell nanocomposites with tailored shell thickness, CNT content and photocatalytic/photoelectrocatalytic properties.

Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra (2011)
Journal Article

Single-molecule characterization is essential for ascertaining the structural and functional properties of bottom-up DNA nanostructures. Here we enlist three atomic force microscopy (AFM) techniques to examine tetrahedron-shaped DNA nanostructures th... Read More about Single-Molecule AFM Characterization of Individual Chemically Tagged DNA Tetrahedra.

Molecular dynamics simulations using graphics processing units (2011)
Journal Article

It is increasingly easy to develop software that exploits Graphics Processing Units (GPUs). The molecular dynamics simulation community has embraced this recent opportunity. Herein, we outline the current approaches that exploit this technology. In t... Read More about Molecular dynamics simulations using graphics processing units.

Scanning electrochemical microscopy at thermal sprayed anti-corrosion coatings: effect of thermal spraying on heterogeneous electron transfer kinetics (2011)
Journal Article

The effect of thermal spraying on the electrochemical activity of an anti-corrosion superalloy was studied quantitatively using scanning electrochemical microscopy (SECM). The superalloy used was Inconel 625 (a Ni base superalloy) and thin coatings o... Read More about Scanning electrochemical microscopy at thermal sprayed anti-corrosion coatings: effect of thermal spraying on heterogeneous electron transfer kinetics.

Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry (2011)
Journal Article

Uniform cellular distribution is a prerequisite to forming tissue within porous scaffolds, but the seeding process often results in preferential adhesion of cells at the periphery. We develop a vapour phase coating strategy which is readily applicabl... Read More about Uniform cell colonization of porous 3-D scaffolds achieved using radial control of surface chemistry.

First principles predictions of thermophysical properties of refrigerant mixtures (2011)
Journal Article

We present pair potentials for fluorinated methanes and their dimers with CO2 based on ab initio potential energy surfaces. These potentials reproduce the experimental second virial coefficients of the pure fluorinated methanes and their mixtures wit... Read More about First principles predictions of thermophysical properties of refrigerant mixtures.

A spoonful of sugar: the application of glycopolymers in therapeutics (2011)
Journal Article

Glycopolymers, synthetic polymers displaying carbohydrate moieties, have been linked to many potential applications at the biology–chemistry interface. One area that holds particular promise is the employment of glycopolymers as vehicles for therapeu... Read More about A spoonful of sugar: the application of glycopolymers in therapeutics.