Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease

Cunliffe, R. N.; Rose, F. R.A.J.; Keyte, J.; Abberley, L.; Chan, W. C.; Mahida, Y. R.

doi:10.1136/gut.48.2.176

All Outputs (44)

Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis (2002)
Journal Article

Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunog... Read More about Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis.

Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe (2002)
Journal Article

A focused series of octapeptides based on the lead compound H-His-Ala-Lys-Arg-Arg-Leu-Ile-Phe-NH2 1, in which the C-terminal phenylalanine residue was replaced by α and/or β-modified variants, was synthesized using solid-phase chemistry. Both the L-t... Read More about Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe.

Homochiral 4-azalysine building blocks: Syntheses and applications in solid-phase chemistry (2002)
Journal Article

Anomalous amino acids not only play central roles as mimics of natural amino acids but also offer opportunities as unique building blocks for combinatorial chemistry. This paper describes the chiral syntheses and solid-phase applications of a versati... Read More about Homochiral 4-azalysine building blocks: Syntheses and applications in solid-phase chemistry.

Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease (2001)
Journal Article

Background and aims - Intestinal epithelial cell derived antimicrobial peptides of the defensin family may play a major role in host defence against microorganisms. Our aims were to (i) isolate, characterise, and investigate the processing of human d... Read More about Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease.