Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms

Vigneswara, Vasanthy; Cass, Simon; Wayne, Declan; Bolt, Edward L.; Ray, David E.; Carter, Wayne

doi:10.1371/journal.pone.0061442

All Outputs (9)

Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease (2021)
Journal Article

Alzheimer’s disease (AD) is a burgeoning social and healthcare problem. Cholinesterase inhibitors (ChEIs) are employed for symptomatic treatment of AD, but often elicit adverse drug reactions (ADRs). Herein, the potency of the ChEIs, donepezil, tacri... Read More about Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease.

Potential nutraceutical properties of leaves from several commonly cultivated plants (2020)
Journal Article

Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase i... Read More about Potential nutraceutical properties of leaves from several commonly cultivated plants.

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review (2020)
Journal Article

The accumulation of abnormal protein aggregates represents a universal hallmark of neurodegenerative diseases (NDDs). Post-translational modifications (PTMs) regulate protein structure and function. Dysregulated PTMs may influence the propensity for... Read More about Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review.

An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress (2019)
Journal Article

Background: Diets rich in fruits, vegetables, and medicinal plants possess antioxidants potentially capable of mitigating cellular oxidative stress. This study investigated the antioxidant, anti-acetylcholinesterase (AChE), and total phenolic and fla... Read More about An investigation of potential sources of nutraceuticals from the Niger Delta areas, Nigeria for attenuating oxidative stress.

Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae) (2018)
Journal Article

Background Glyphae brevis leaf is reported in ethnomedicine as a treatment for hepatitis and jaundice; however, no studies have hitherto investigated the mechanistic basis of these claims. Methods A hepato-protective role of G. brevis hydromet... Read More about Alleviation of carbon tetrachloride-induced hepatocellular damage and oxidative stress with a leaf extract of Glyphae brevis (Tiliaceae).

In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria (2018)
Journal Article

Background: Polyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases and anti-oxidant properties. Methods: Anti-cholinesterase, anti-oxidant, and total phenolic and f... Read More about In vitro anti-cholinesterase and anti-oxidant activity of three standardised polyherbal products used for memory enhancing in ethnomedicine of South-East Nigeria.

Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity (2018)
Journal Article

Objective Spondias mombin L. is a tree used in folk medicine in Nigeria for the treatment of hepatitis. This study was carried out to comparatively evaluate the hepatoprotective and antioxidant effects of S. mombin leaf and stem (SML and SMS) meth... Read More about Hepatoprotective and antioxidant activities of Spondias mombin leaf and stem extracts against carbon tetrachloride-induced hepatotoxicity.

Alcohol-related brain damage in humans (2014)
Journal Article

Chronic excessive alcohol intoxications evoke cumulative damage to tissues and organs. We examined prefrontal cortex (Brodmann’s area (BA) 9) from 20 human alcoholics and 20 age, gender, and postmortem delay matched control subjects. H & E staining a... Read More about Alcohol-related brain damage in humans.

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article

Abnormal ?-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and ?-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More about Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms.