All Outputs (11)

Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock (2020)
Journal Article

© 2020, The Author(s). Geoffrey Burnstock made groundbreaking discoveries on the physiological roles of purinergic receptors and led on P2 purinergic receptor classification. His knowledge, vision and leadership inspired and influenced the internatio... Read More about Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock.

An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification (2020)
Journal Article

© Copyright © 2020 Millar, John, McIntyre, Ralevic, Anderson and O'Sullivan. Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD)... Read More about An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification.

Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes (2018)
Journal Article

Background: There is clinical and experimental evidence for altered adenosine signalling in the fetoplacental circulation in pregnancies complicated by diabetes, leading to adenosine accumulation in the placenta. However, the consequence for fetoplac... Read More about Impaired vasocontractile responses to adenosine in chorionic vessels of human term placenta from pregnant women with pre-existing and gestational diabetes.

Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase (2018)
Journal Article

Aim: Hypoxia causes vasodilatation of coronary arteries which protects the heart from ischaemic damage through mechanisms including the generation of hydrogen sulfide (H2S), but the influence of the perivascular adipose tissue (PVAT) and myocardium i... Read More about Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulfide and cystathionine-β-synthase.

UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery (2017)
Journal Article

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known about their cardiovascular actions. The P2Y14 receptor is a Gi/o-coupled receptor which is activated by UDP-glucose and related sugar nucleotides. In thi... Read More about UDP-sugars activate P2Y 14 receptors to mediate vasoconstriction of the porcine coronary artery.

A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery (2017)
Journal Article

Hypoxia-induced coronary artery vasodilatation protects the heart by increasing blood flow under ischemic conditions, however its mechanism is not fully elucidated. Hydrogen sulfide (H2S) is reported to be an oxygen sensor/transducer in the vasculatu... Read More about A critical role for cystathionine-?-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.

Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release (2017)
Journal Article

Aims: Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch... Read More about Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release.

Effects of NAD at purine receptors in isolated blood vessels (2014)
Journal Article

Nicotinamide adenine dinucleotide (NAD) belongs to the family of naturally occurring adenine dinucleotides, best known for their various intracellular roles. However, there is evidence that they can also be released from cells to act as novel extrace... Read More about Effects of NAD at purine receptors in isolated blood vessels.

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed (2014)
Journal Article

The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries. The a... Read More about Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed.

Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries (2014)
Journal Article

Background and Purpose: The P2Y14 receptor is the newest member of the P2Y receptor family; it is Gi/o protein-coupled and is activated by UDP and selectively by UDP-glucose and MRS2690 (2-thiouridine-5′-diphosphoglucose) (7–10-fold more potent than... Read More about Novel vasocontractile role of the P2Y14receptor: characterization of its signalling in porcine isolated pancreatic arteries.

Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries (2013)
Journal Article

Receptors for purines and pyrimidines are expressed throughout the cardiovascular system. This study investigated their functional expression in porcine isolated pancreatic arteries. Pancreatic arteries (endothelium intact or denuded) were prepared f... Read More about Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries.