All Outputs (10)

Characterization of neuronal viability and network activity under microfluidic flow (2021)
Journal Article

Background: Microfluidics technology has the potential to allow precise control of the temporal and spatial aspects of solute concentration, making it highly relevant for the study of volume transmission mechanisms in neural tissue. However, full uti... Read More about Characterization of neuronal viability and network activity under microfluidic flow.

A statistical view on calcium oscillations (2019)
Journal Article

Transient rises and falls of the intracellular calcium concentration have been observed in numerous cell types and under a plethora of conditions. There is now a growing body of evidence that these whole-cell calcium oscillations are stochastic, whic... Read More about A statistical view on calcium oscillations.

Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission (2018)
Journal Article

At parallel fibre terminals in the cerebellar cortex, glutamate released outside of the active zone can activate AMPA receptors on juxtaposed Bergmann glial cell processes. This process is termed “ectopic” release, and allows for directed transmissio... Read More about Distribution of vesicle pools in cerebellar parallel fibre terminals after depression of ectopic transmission.

A Bayesian approach to modelling heterogeneous calcium responses in cell populations (2017)
Journal Article

Calcium responses have been observed as spikes of the whole-cell calcium concentration in numerous cell types and are essential for translating extracellular stimuli into cellular responses. While there are several suggestions for how this encoding i... Read More about A Bayesian approach to modelling heterogeneous calcium responses in cell populations.

Probabilistic encoding of stimulus strength in astrocyte global calcium signals (2015)
Journal Article

© 2016 Wiley Periodicals, Inc. Astrocyte calcium signals can range in size from subcellular microdomains to waves that spread through the whole cell (and into connected cells). The differential roles of such local or global calcium signaling are unde... Read More about Probabilistic encoding of stimulus strength in astrocyte global calcium signals.

Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity. (2015)
Journal Article

Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum. (2015)
Journal Article

In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2+-perm... Read More about Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum..

Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling (2015)
Journal Article

Background Cerebellar parallel fibres release glutamate at both the synaptic active zone and at extrasynaptic sites—a process known as ectopic release. These sites exhibit different short-term and long-term plasticity, the basis of which is incomple... Read More about Caffeine modulates vesicle release and recovery at cerebellar parallel fibre terminals, independently of calcium and cyclic AMP signalling.

Stimulus Discrimination in Cerebellar Purkinje Neurons (2014)
Journal Article

Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic input. Overlaid on this intrinsic activity, excitatory input from parallel fibres can add simple spikes to the output train, whereas inhibitory input from interneurons can intr... Read More about Stimulus Discrimination in Cerebellar Purkinje Neurons.

Ectopic release of glutamate contributes to spillover at parallel fibre synapses in the cerebellum (2014)
Journal Article