Katharina Reusch
Stimulus Discrimination in Cerebellar Purkinje Neurons
Reusch, Katharina; Russell, Noah A.; Bellamy, Tomas C.
Abstract
Cerebellar Purkinje neurons fire spontaneously in the absence of synaptic input. Overlaid on this intrinsic activity, excitatory input from parallel fibres can add simple spikes to the output train, whereas inhibitory input from interneurons can introduce pauses. These and other influences lead to an irregular spike train output in Purkinje neurons in vitro and in vivo, supplying a variable inhibitory drive to deep cerebellar nuclear neurons. From a computational perspective, this variability raises some questions, as individual spikes induced by excitatory inputs are indistinguishable from intrinsic firing activity. Although bursts of high-frequency excitatory input could be discriminated unambiguously from background activity, granule neurons are known to fire in vivo over a wide range of frequencies. This would mean that much of the sensory information relayed through the cerebellar cortex would be lost within the random variation in background activity. We speculated that alternative mechanisms for signal discrimination may exist, and sought to identify characteristic motifs within the sequence of spikes that followed stimulation events. We found that under certain conditions, parallel fibre stimulation could reliably add a “couplet” of spikes with an unusually short interspike interval to the output train. Therefore, despite representing a small fraction of the total number of spikes, these signals can be reliably discriminated from background firing on a moment-to-moment basis, and could result in a differential downstream response.
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 30, 2013 |
Online Publication Date | Feb 5, 2014 |
Publication Date | Feb 5, 2014 |
Deposit Date | Jul 13, 2018 |
Publicly Available Date | Oct 9, 2020 |
Journal | PLoS ONE |
Electronic ISSN | 1932-6203 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 9 |
Issue | 2 |
Article Number | e87828 |
DOI | https://doi.org/10.1371/journal.pone.0087828 |
Public URL | https://nottingham-repository.worktribe.com/output/1099503 |
Publisher URL | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087828 |
PMID | 24505320 |
Files
Correction: Stimulus Discrimination in Cerebellar Purkinje Neurons
(143 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
Stimulus Discrimination in Cerebellar Purkinje Neurons
(2.4 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
You might also like
A statistical view on calcium oscillations
(2019)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search