Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial

Bath, Philip M; Scutt, Polly; Anderson, Craig S; Appleton, Jason P; Berge, Evind; Cala, Lesley; Dixon, Mark; England, Timothy M; Godolphin, Peter J; Havard, Diane; Haywood, Lee; Hepburn, Trish; Krishnan, Kailash; Mair, Grant; Montgomery, Alan A; Muir, Keith; Phillips, Stephen J; Pocock, Stuart; Potter, John; Price, Chris; Randall, Marc; Robinson, Thompson G; Roffe, Christine; Rothwell, Peter M; Sandset, Else C; Sanossian, Nerses; Saver, Jeffrey L; Shone, Angela; Niroshan Siriwardena, A; Wardlaw, Joanna M; Woodhouse, Lisa J; Venables, Graham; Sprigg, Nikola; Amarenco, Pierre; Muir, Keith; Amoils, Shannon; Jarvis, Malcolm; Rothwell, Peter M; Sandercock, Peter; Asplund, Kjell; Baigent, Colin; Ankolekar, Sandeep; Howard, Harriet; Lysons, Christopher; Walker, Gemma; Gregory, Hayley; Kirby, James; Smithson, Jennifer; Keeling, Joanne; Frowd, Nadia; Gray, Robert; Dooley, Richard; Clarke, Wim; Robinson, Patricia; Kang Law, Zhe; Hodgson, Sheila; Millington, Adam; Sakka, Eleni; Buchanan, David; Palmer, Jeb; Shaw, D; Cobb, H; Johnson, R; Payne, T; Spaight, R; Spaight, A; Sajid, M A; Whileman, A; Hall, E; Cripps, H; Toms, J; Gascoyne, R; Wright, S; Cooper, M; Palfreman, A; Rajapakse, A; Wynter, I; Musarrat, K; Mistri, A; Patel, C; Stephens, C; Khan, S; Patras, S; Soliman, M; Elmarimi, A; Hewitt, C; Watson, E; Wahishi, I; Hindle, J; Perkin, L; Wills, M; Arif, S; Leach, S; Butler, S; O'Kane, D; Smith, C; O'Callaghan, J; Sunman, W; Buck, A; Jackson, B; Richardson, C; Wilkes, G; Clarke, J; Ryan, L; Matias, O; Mangion, D; Hardwick, A; Constantin, C; Thomas, I; Netherton, K; Markova, S; Hedstrom, A; Rushton, B; Hyde, C; Scott, J; Blair, M; Maddula, M; Donnelly, R; Keane, S; Johnson, S; McKenzie, H; Banerjee, A; Hutchinson, D; Goodhand, H; Hill, J; Mellows, K; Cheeseman, M; McTaggart, V; Foster, T; Prothero, L; Saksena, P; O'Kelly, A; Wyllie, H; Hacon, C; Nutt, H; North, J; Goffin, K; Potter, J; Wiltshire, A; Ravenhill, G; Metcalf, K; Ford, L; Langley, M; Davison, W; Subramonian, S; Magezi, F; Obi, I; Temple, N; Butterworth-Cowin, N; Oqwusu-Agyei, P; Azim, A F M; Nicolson, A; Imam, J; White, J; Wood, L; Fothergill, R; Thompson, N; Lazarus, J; Werts, H; Sztriha, L; Ho, C; McKenzie, E; Owoyele, E; Lim, J; Aeron-Thomas, J; Dockey, M; Sylvester, N; Rao, P; Bloom, B M; Erumere, E; Norman, G; Skene, I; Cuenoud, L; Howaniec, L; Boulton, O; Daboo, P; Michael, R; Al-Saadi, S; Harrison, T; Syed, H; Argandona, L; Amiani, S; Perry, R; Ashton, A; Banaras, A; Hogan, C; Watchurst, C; Elliott, E; Francia, N; Oji, N; Erande, R; Obarey, S; Feerick, S; Tshuma, S; England, E; Pocock, H; Poole, K; Manchanda, S; Burn, I; Dayal, S; McNee, K; Robinson, M; Hancock, R; South, A; Holmes, C; Steele, A; Guthrie, L B; Oborn, M; Mohd Nor, A; Hyams, B; Eglinton, C; Waugh, D; Cann, E; Wilmhurst, N; Piesley, S; Shave, S; Dutta, D; Obeid, M; Ward, D; Turfrey, J; Glass, J; Bowstead, K; Hill, L; Brown, P; Beames, S; O'Connell, S; Hughes, V; Whiting, R; Gagg, J; Hussain, M; Harvey, M; Karunatilake, D; Pusuluri, B; Witcher, A; Pawley, C; Allen, J; Foot, J; Rowe, J; Lane, C; Ragab, S; Wadams, B; Dube, J; Jupp, B; Ljubez, A; Bagnall, C; Hann, G; Tucker, L; Kelton, M; Orr, S; Harrington, F; James, A; Lydon, A; Courtauld, G; Bond, K; Lucas, L; Nisbett, T; Kubie, J; Bowring, A; Jennings, G; Thorpe, K; Mason, N; Keenan, S; Gbadomishi, L; Howcroft, D; Newton, H; Choulerton, J; Avis, J; Shaw, L; Paterson, P; Kaye, P; Hierons, S; Lucas, S; Clatworthy, P; Faulkner, B; Rannigan, L; Worner, R; Bhaskaran, B; Saulat, A; Bearne, H; Garfield-Smith, J; Horan, K; Fitzell, P; Szabo, S; Haley, M; Simmons, D; Cotterill, D; Saunders, G; Dymond, H; Beech, S; Rashed, K; Tanate, A; Buckley, C; Wood, D; Matthews, L; Board, S; Pitt-Kirby, T; Rees, N; Convery, C; Jones, P; Bryant, C; Tench, H; Dixon, M; Loosley, R; Coetzee, S; Jones, S; Sims, T; Krishnan, M; Davies, C; Quinn, L; Connor, L; Wani, M; Storton, S; Treadwell, S; Anjum, T; Somashekar, C; Chandler, A; Triscott, C; Bevan, L; Sander, M; Buckle, S; Sayed, W; Andrews, K; Hughes, L; Hughes, R; Ward, M; Pretty, A; Rosser, A; Davidson, B; Price, G; Gunson, I; Lumley-Holmes, J; Miller, J; Larden, M; Jhamat, M; Horwood, P; Boldy, R; Jenkins, C; Price, F; Harrison, M; Martin, T; Ahmad, N; Willberry, A; Stevens, A; Fotherby, K; Barry, A; Remegoso, A; Alipio, F; Maquire, H; Hiden, J; Finney, K; Varquez, R; Ispoglou, S; Hayes, A; Gull, D; Evans, R; Epstein, E; Hurdowar, S; Crossley, J; Miles, J; Hird, K; Pilbery, R; Patterson, C; Ramadan, H; Stewart, K; Quinn, O; Bellfield, R; Macquire, S; Gaba, W; Nair, A; Wilson, A; Hawksworth, C; Alam, I; Greig, J; Robinson, M; Gomes, P; Rana, P; Ahmed, Z; Anderston, P; Neal, A; Walstow, D; Fong, R; Brotheridge, S; Bwalya, A; Gillespie, A; Midgley, C; Hare, C; Lyon, H; Stephenson, L; Broome, M; Worton, R; Jackson, S; Rayessa, R; Abdul-Hamid, A; Naylor, C; Clarkson, E; Hassan, A; Waugh, D; Veraque, E; Finch, L; Makawa, L; Carpenter, M; Datta, P; Needle, A; Jackson, L; Brooke, H J; Ball, J; Lowry, T; Punnoose, S; Walker, R; Murray, V; Ali, A; Kamara, C; Doyle, C; Richards, E; Howe, J; Dakin, K; Harkness, K; Lindert, R; Wanklyn, P; Willcoxson, P; Clark-Brown, P; Mir, R

doi:10.1016/S0140-6736(19)30194-1

The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review (2019)
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Importance: While there are a limited number of beneficial treatments for acute stroke (eg, stroke units, reperfusion, aspirin, hemicraniectomy), there are more negative (as opposed to neutral) interventions spanning multiple different mechanisms of... Read More about The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review.

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Background and purpose Blend, black hole and island signs and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage (ICH). We explored the value of these noncontrast CT (NCCT) signs in predicting hematoma expan... Read More about Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage.

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
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Background and Purpose— Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset. Methods— We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

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Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT (2019)
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Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial (2019)
Journal Article

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure... Read More about Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial.

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