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A systematic review of cannabidiol dosing in clinical populations

Millar, Sophie A.; Stone, N.L.; Bellman, Z.D.; Yates, A.S.; England, T.J.; O'Sullivan, S.E.

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Authors

Sophie A. Millar

N.L. Stone

Z.D. Bellman

A.S. Yates

S.E. O'Sullivan



Abstract

Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of medical contexts.
Methods: Publications involving administration of cannabidiol alone were collected by searching PubMed, EMBASE and ClinicalTrials.gov.
Results: A total of 1038 articles were retrieved, of which 35 studies met inclusion criteria covering 13 medical contexts. 23 studies reported a significant improvement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), with doses ranging between

Citation

Millar, S. A., Stone, N., Bellman, Z., Yates, A., England, T., & O'Sullivan, S. (2019). A systematic review of cannabidiol dosing in clinical populations. British Journal of Clinical Pharmacology, 85(9), 1888-1900. https://doi.org/10.1111/bcp.14038

Journal Article Type Article
Acceptance Date Jun 10, 2019
Online Publication Date Jul 19, 2019
Publication Date 2019-09
Deposit Date Jun 20, 2019
Publicly Available Date Mar 29, 2024
Journal British Journal of Clinical Pharmacology
Print ISSN 0306-5251
Electronic ISSN 1365-2125
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 85
Issue 9
Pages 1888-1900
DOI https://doi.org/10.1111/bcp.14038
Keywords cannabidiol; cannabinoid; therapeutics; dose; dosing 11
Public URL https://nottingham-repository.worktribe.com/output/2212209
Publisher URL https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.14038