A systematic review of cannabidiol dosing in clinical populations

Millar, Sophie A.; Stone, N.L.; Bellman, Z.D.; Yates, A.S.; England, T.J.; O'Sullivan, S.E.

Abstract

Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of medical contexts.
Methods: Publications involving administration of cannabidiol alone were collected by searching PubMed, EMBASE and ClinicalTrials.gov.
Results: A total of 1038 articles were retrieved, of which 35 studies met inclusion criteria covering 13 medical contexts. 23 studies reported a significant improvement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), with doses ranging between

Citation

Millar, S. A., Stone, N., Bellman, Z., Yates, A., England, T., & O'Sullivan, S. (2019). A systematic review of cannabidiol dosing in clinical populations. British Journal of Clinical Pharmacology, 85(9), 1888-1900. https://doi.org/10.1111/bcp.14038

• Journal Article Type: Article
• Acceptance Date: Jun 10, 2019
• Online Publication Date: Jul 19, 2019
• Publication Date: 2019-09
• Deposit Date: Jun 20, 2019
• Publicly Available Date: Aug 29, 2019
• Journal: British Journal of Clinical Pharmacology
• Print ISSN: 0306-5251
• Electronic ISSN: 1365-2125
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 85
• Issue: 9
• Pages: 1888-1900
• DOI: https://doi.org/10.1111/bcp.14038
• Keywords: cannabidiol; cannabinoid; therapeutics; dose; dosing 11
• Public URL: https://nottingham-repository.worktribe.com/output/2212209
• Publisher URL: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.14038
• Contract Date: Aug 29, 2019