All Outputs (19)

Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements (2021)
Journal Article

© 2021 Elsevier B.V. Skin prick testing (SPT) and measurement of serum allergen-specific IgE (sIgE) are used to investigate asthma and other allergic conditions. Measurement of serum total IgE (tIgE) and allergen-specific IgG4 (sIgG4) may also be use... Read More about Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements.

Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial (2020)
Journal Article

Background Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driv... Read More about Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.

Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial (2020)
Journal Article

Background Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are associated with important outcomes in mild asthma is unclear. In this prespecified subgroup analysis of a previously published open-label clinical trial, we aimed to asse... Read More about Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial.

Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma (2019)
Journal Article

BACKGROUND In double-blind, placebo-controlled trials, budesonide–formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation of asthma than as-needed use of a short-acting β2-agonist (SABA); the risk was similar to that of... Read More about Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma.

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST (2018)
Journal Article

Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations (2018)
Journal Article

Copyright © 2018 Massachusetts Medical Society. BACKGROUND Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a te... Read More about Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations.

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial (2018)
Journal Article

Background: Patients with difficult-to-control asthma consume 50–60% of healthcare costs attributed to asthma and cost approximately five-times more than patients with mild stable disease. Recent evidence demonstrates that not all patients with asthm... Read More about A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations (2016)
Journal Article

BACKGROUND: Asthma is one of the commonest chronic diseases in the UK. Acute exacerbations of asthma are unpredictable, disruptive and frightening. They cause considerable morbidity and account for a large component of the health service costs of ast... Read More about FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations.

The differential effects of azithromycin on the airway epithelium in vitro and in vivo (2016)
Journal Article

Macrolides including azithromycin (AZM) can improve clinical symptoms in asthma regardless of infection status. The mechanisms underlying these benefi- cial effects are yet to be elucidated. The aim of this study was to determine the effect of AZM on... Read More about The differential effects of azithromycin on the airway epithelium in vitro and in vivo.

Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial (2016)
Journal Article

IMPORTANCE Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use. OBJECTIVE To determine whether azithromycin added to standard care for asthma attacks i... Read More about Azithromycin for Acute Exacerbations of Asthma: the AZALEA randomized clinical trial.

Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease (2016)
Journal Article

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More about Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma (2016)
Journal Article

Current clinical tests employed to diagnose asthma are inaccurate and limited by their invasive nature. New metabolite profiling technologies offer an opportunity to improve asthma diagnosis using non-invasive sampling. A rapid analytical method for... Read More about Untargeted metabolic profiling of saliva by liquid chromatography-mass spectrometry for the identification of potential diagnostic biomarkers of asthma.

Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study (2015)
Journal Article

Introduction: Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are more difficult to obtain than venous. We assessed... Read More about Using venous blood gas analysis in the assessment of COPD exacerbations: a prospective cohort study.

A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA) (2015)
Journal Article

Background: Some patients with refractory asthma have evidence of uncontrolled eosinophilic inflammation in the distal airways. While traditional formulations of inhaled steroids settle predominantly in the large airways, newer formulations with an e... Read More about A randomised controlled trial of small particle inhaled steroids in refractory eosinophilic asthma (SPIRA).

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article

BACKGROUND: There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study (2014)
Journal Article

Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations (2014)
Journal Article

The impact of azithromycin therapy on the airway microbiota in asthma (2014)
Journal Article

There is interest in the use of macrolide antibiotics in asthma. Macrolides have been shown to improve airway hyperresponsiveness (AHR) and measures of airway inflammation.The degree of AHR may relate to the microbiota present in the airways, with a... Read More about The impact of azithromycin therapy on the airway microbiota in asthma.