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Therapeutic potential of miRNAs in Clostridioides difficile infection (2022)
Journal Article
Monaghan, T. M., Polytarchou, C., Kao, D., Alexander, C., & Gurnani, P. (2022). Therapeutic potential of miRNAs in Clostridioides difficile infection. Future Microbiology, 17(5), 315-318. https://doi.org/10.2217/fmb-2021-0311

Treating Clostridioides difficile infection with miRNAs alone or combined with live biotherapeutic products may augment therapeutic efficacy and help counteract drug resistance in the future.

Clostridioides difficile epidemiology in India (2022)
Journal Article
Monaghan, T. M., Biswas, R., Satav, A., Ambalkar, S., & Kashyap, R. S. (2022). Clostridioides difficile epidemiology in India. Anaerobe, 74, Article 102517. https://doi.org/10.1016/j.anaerobe.2022.102517

Clostridioides difficile infection (CDI) continues to affect hospitalized patients and community populations worldwide. In contrast to the substantial resources invested in the diagnosis and prevention of CDI in high-income countries, this anaerobic... Read More about Clostridioides difficile epidemiology in India.

Clostridioides difficile: innovations in target discovery and potential for therapeutic success (2021)
Journal Article
Monaghan, T. M., Seekatz, A. M., Mullish, B. H., Moore-Gillon, C. E., Dawson, L., Ahmed, A., …Chan, W. C. (2021). Clostridioides difficile: innovations in target discovery and potential for therapeutic success. Expert Opinion on Therapeutic Targets, 25(11), 949-963. https://doi.org/10.1080/14728222.2021.2008907

Introduction: Clostridioides difficile infection (CDI) remains a worldwide clinical problem. Increased incidence of primary infection, occurrence of hypertoxigenic ribotypes, and more frequent occurrence of drug resistant, recurrent, and non-hospital... Read More about Clostridioides difficile: innovations in target discovery and potential for therapeutic success.

Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre (2021)
Journal Article
Voona, S., Abdic, H., Montgomery, R., Clarkson, A., Twitchell, H., Hills, T., …Monaghan, T. M. (2022). Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre. Anaerobe, 73, Article 102479. https://doi.org/10.1016/j.anaerobe.2021.102479

Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community... Read More about Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre.

A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection (2021)
Journal Article
Monaghan, T. M., Duggal, N. A., Rosati, E., Griffin, R., Hughes, J., Roach, B., …Kao, D. H. (2021). A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection. Cells, 10(11), Article 3234. https://doi.org/10.3390/cells10113234

Fecal microbiota transplantation (FMT) is highly effective in recurrent Clostridioides difficile infection (CDI); increasing evidence supports FMT in severe or fulminant Clostridioides difficile infection (SFCDI). However, the multifactorial mechanis... Read More about A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection.

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle (2021)
Journal Article
Chidambaram, S. B., Essa, M. M., Rathipriya, A., Bishir, M., Ray, B., Mahalakshmi, A. M., …Monaghan, T. M. (2022). Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle. Pharmacology and Therapeutics, 231, Article 107988. https://doi.org/10.1016/j.pharmthera.2021.107988

The human microbiota comprises trillions of symbiotic microorganisms and is involved in regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis. Recent observations suggest a bidirectional communication between the gut micr... Read More about Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle.

Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India (2021)
Journal Article
Monaghan, T. M., Biswas, R. N., Nashine, R. R., Joshi, S. S., Mullish, B. H., Seekatz, A. M., …Kashyap, R. S. (2021). Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India. Microorganisms, 9(7), Article 1485. https://doi.org/10.3390/microorganisms9071485

Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consu... Read More about Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India.

Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs (2021)
Journal Article
Monaghan, T. M., Seekatz, A. M., Markham, N. O., On Yau, T., Hatziapostolou, M., Jilani, T., …Polytarchou, C. (2021). Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs. Gastroenterology, 161(1), 255-270.e4. https://doi.org/10.1053/j.gastro.2021.03.050

Background and aims The molecular mechanisms underlying successful fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) remain poorly understood. The primary objective of this study was to characterize alter... Read More about Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs.

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection (2020)
Journal Article
Huus, K. E., Frankowski, M., Pučić-Baković, M., Vučković, F., Lauc, G., Mullish, B. H., …Finlay, B. B. (2021). Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection. Gut Microbes, 13(1), 1-12. https://doi.org/10.1080/19490976.2020.1862027

Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental fa... Read More about Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection.

Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites (2020)
Journal Article
Martinez-Gili, L., McDonald, J. A., Liu, Z., Kao, D., Allegretti, J. R., Monaghan, T. M., …Mullish, B. H. (2020). Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes, 12(1), Article 1810531. https://doi.org/10.1136/gutjnl-2018-317842

Fecal microbiota transplant (FMT) is a highly-effective therapy for recurrent Clostridioides difficile infection (rCDI), and shows promise for certain non-CDI indications. However, at present, its mechanisms of efficacy have remained poorly understo... Read More about Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites.

Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., …Singh Kashyap, R. (2020). Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome. Gut Microbes, 12(1), Article 1752605

Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrhoeal diseases, particularly Clostridioides difficile, in rural-agricultural and urban popula... Read More about Metagenomics Reveals Impact of Geography and Acute Diarrhoeal Disease on the Central Indian Human Gut Microbiome.

Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome (2020)
Journal Article
Monaghan, T. M., Sloan, T. J., Stockdale, S. R., Blanchard, A. M., Emes, R. D., Wilcox, M., …Kashyap, R. S. (2020). Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome. Gut Microbes, 12(1), Article 1752605. https://doi.org/10.1080/19490976.2020.1752605

© 2020, © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. Background: The Central Indian gut microbiome remains grossly understudied. Herein, we sought to investigate the burden of antimicrobial resistance and diarrheal d... Read More about Metagenomics reveals impact of geography and acute diarrheal disease on the Central Indian human gut microbiome.

Setting the agenda for social science research on the human microbiome (2020)
Journal Article
Greenhough, B., Read, C. J., Lorimer, J., Lezaun, J., McLeod, C., Benezra, A., …Wills, J. (2020). Setting the agenda for social science research on the human microbiome. Palgrave Communications, 6(2020), Article 18

The human microbiome is an important emergent area of cross, multi and transdisciplinary study. The complexity of this topic leads to conflicting narratives and regulatory challenges. It raises questions about the benefits of its commercialisation an... Read More about Setting the agenda for social science research on the human microbiome.

Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection (2019)
Journal Article
Monaghan, T. M., Pu?i?-Bakovi?, M., Vu?kovi?, F., Lee, C., Kao, D., & Human Glycome Project, . (2020). Decreased Complexity of Serum N-glycan Structures Associates with Successful Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection. Gastroenterology, 157(6), 1676-1678.e3. https://doi.org/10.1053/j.gastro.2019.08.034

In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation (2019)
Journal Article
McSweeney, B., Allegretti, J. R., Fischer, M., Xu, H., Goodman, K. J., Monaghan, T., …Kao, D. (2020). In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation. Gut Microbes, 11(1), 51-62. https://doi.org/10.1080/19490976.2019.1611153

Introduction: Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection. Stool donors are essential, but difficult to recruit and retain. We identified factors influencing willingness to donate... Read More about In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.

Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection (2019)
Journal Article
Braim, S., Śpiewakb, K., Brindell, M., Heeg, D., Alexander, C., & Monaghan, T. (2019). Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection. Journal of Pharmaceutical Sciences, 108(7), 2438-2446. https://doi.org/10.1016/j.xphs.2019.02.025

Some forms of bovine lactoferrin (bLf) are effective in delaying Clostridioides difficile growth and preventing toxin production. However, therapeutic use of bLf may be limited by protein stability issues. The objective of this study was to prepare a... Read More about Lactoferrin-Loaded Alginate Microparticles to Target Clostridioides difficile Infection.