All Outputs (4)

Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds (2020)
Journal Article
Morris, T. H., Paine, S. W., Zahra, P. W., Li, E. C., Colgan, S. .., & Karamatic, S. L. (2020). Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds. Australian Veterinary Journal, 98(12), 578-585. https://doi.org/10.1111/avj.13014

Animals used in sport should be treated as required to ensure animal welfare but any such use of medication should also be controlled to ensure integrity. Pharmacokinetic studies on groups of six greyhounds were performed to measure plasma and urine... Read More about Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds.

Prediction of Pharmacokinetic Clearance and Potential Drug-Drug Interactions for Omeprazole in the Horse using in vitro Systems (2020)
Journal Article
Shibany, K. A., Pratt, S. L., Aldurdunji, M., Totemeyer, S., & Paine, S. W. (2020). Prediction of Pharmacokinetic Clearance and Potential Drug-Drug Interactions for Omeprazole in the Horse using in vitro Systems. Xenobiotica, 50(10), 1220-1227. https://doi.org/10.1080/00498254.2020.1764131

Horses are exposed to various kinds of medication, however, there are limited determinations of plasma clearance (CLp) for the drugs used due to the high cost of equine in vivo studies. Many of the CLp values generated come from the equine sports ind... Read More about Prediction of Pharmacokinetic Clearance and Potential Drug-Drug Interactions for Omeprazole in the Horse using in vitro Systems.

Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway (2020)
Journal Article
Burton, L., Scaife, P., Paine, S. W., Mellor, H. R., Abernethy, L., Littlewood, P., & Rauch, C. (2020). Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway. American Journal of Physiology - Cell Physiology, 318(5), C889-C902. https://doi.org/10.1152/ajpcell.00472.2019

Approximately 75% of xenobiotics are primarily eliminated through metabolism; thus the accurate scaling of metabolic clearance is vital to successful drug development. Yet, when data is scaled from in vitro to in vivo, hepatic metabolic clearance, th... Read More about Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses (2020)
Journal Article
Paine, S. W., Bright, J., Scarth, J. P., Hincks, P. R., Pearce, C. M., Hannan, C., …Hillyer, L. (2020). The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses. Journal of Veterinary Pharmacology and Therapeutics, 43(2), 162-170. https://doi.org/10.1111/jvp.12838

In equine and racing practice, detomidine and butorphanol are commonly used in combination for their sedative properties. The aim of the study was to produce detection times to better inform European veterinary surgeons, so that both drugs can be use... Read More about The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.