Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development

H-T. Kwok, Charlie; Devonshire, Ian M.; Imraish, Amer; Greenspon, Charles M.; Lockwood, Stevie; Fielden, Catherine; Cooper, Andrew; Woodhams, Stephen; Sarmad, Sarir; Ortori, Catherine A.; Barrett, David A.; Kendall, David; Bennett, Andrew J.; Chapman, Victoria; Hathway, Gareth J.

doi:10.1097/j.pain.0000000000001027

All Outputs (2)

Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain (2023)
Journal Article

We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD f... Read More about Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain.

Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More about Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development.