Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

Corriden, Ross; Self, Tim; Akong-Moore, Kathryn; Nizet, Victor; Kellam, Barrie; Briddon, Stephen J.; Hill, Stephen J.

doi:10.1038/embor.2013.89

All Outputs (2)

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization (2014)
Journal Article

Keywords:adenosine;allosterism;receptor;GPCR;dimerization;biased signalling The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It is released under a variety of physiological and pathophysiological condition... Read More about Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization.

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes (2013)
Journal Article

The A3‐adenosine receptor (A3AR) has recently emerged as a key regulator of neutrophil behaviour. Using a fluorescent A3AR ligand, we show that A3ARs aggregate in highly polarized immunomodulatory microdomains on human neutrophil membranes. In additi... Read More about Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.