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All Outputs (42)

Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review (2020)
Journal Article
Pandya, T., Dale, S., Donnison, E., & Kluzek, S. (2020). Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review. Clinical Case Reports, 8(9), 1682-1685. https://doi.org/10.1002/ccr3.2960

Diagnosis of fifth metacarpal head fracture with collateral ligament injuries can be difficult. We present a case of a professional cricketer with a fifth metacarpal head fracture. who played a match before pain made the injury obvious. Following im... Read More about Conservative management of fifth metacarpal head fracture in a professional cricketer: A case study and literature review.

Symptomatic stress reaction of the humerus in a professional cricketer (2019)
Journal Article
Beech, M., Nagra, N. S., Wedatilake, T., & Kluzek, S. (2019). Symptomatic stress reaction of the humerus in a professional cricketer. BMJ Case Reports, 12(9), https://doi.org/10.1136/bcr-2018-227088

A symptomatic bone stress reaction is an early pathological feature, which can lead to stress fractures. It typically affects bones of the lower limbs in response to unaccustomed disproportional compressive loading. Professional sportspeople are susc... Read More about Symptomatic stress reaction of the humerus in a professional cricketer.

Machine-learning for osteoarthritis research (2019)
Journal Article
Kluzek, S., & Mattei, T. (2019). Machine-learning for osteoarthritis research. Osteoarthritis and Cartilage, 27(7), 977-978. https://doi.org/10.1016/j.joca.2019.04.005

Machine learning (ML) algorithms have the ability to automatically learn and improve from experience without being specifically directed. There has been great optimism that such techniques may improve scientific biomedical research in several fields1... Read More about Machine-learning for osteoarthritis research.

Interleukin-17 is a potential contributor to the inflammatory environment in the OA joint (2019)
Journal Article
Mimpen, J., Kluzek, S., Price, A., Snelling, S., Watt, F., Dakin, S., & Carr, A. (2019). Interleukin-17 is a potential contributor to the inflammatory environment in the OA joint. Osteoarthritis and Cartilage, 27(S1), S379. https://doi.org/10.1016/j.joca.2019.02.377+showArticle+Info

Purpose: Osteoarthritis (OA) has been historically viewed as a degenerative disease caused by ‘wear and tear’, with the loss of articular cartilage as the most important clinical feature. Modern imaging techniques have shown us over the last decade t... Read More about Interleukin-17 is a potential contributor to the inflammatory environment in the OA joint.

Risk of Injury in Royal Air Force Training: Does Sex Really Matter? (2018)
Journal Article
Fallowfield, J. L., Leiper, R. G., Shaw, A. M., Whittamore, D. R., Lanham-New, S. A., Allsopp, A. J., …Sanchez-Santos, M. T. (2020). Risk of Injury in Royal Air Force Training: Does Sex Really Matter?. Military Medicine, 185(1-2), 170–177. https://doi.org/10.1093/milmed/usy177

Introduction Musculoskeletal injuries are common during military and other occupational physical training programs. Employers have a duty of care to reduce employees’ injury risk, where females tend to be at greater risk than males. However, quant... Read More about Risk of Injury in Royal Air Force Training: Does Sex Really Matter?.

Therapeutic interventions in children and adolescents with patellar tendon related pain: a systematic review (2018)
Journal Article
Cairns, G., Owen, T., Kluzek, S., Thurley, N., Holden, S., Rathleff, M. S., & Dean, B. J. F. (2018). Therapeutic interventions in children and adolescents with patellar tendon related pain: a systematic review. BMJ Open Sport and Exercise Medicine, 4(1), https://doi.org/10.1136/bmjsem-2018-000383

Objective: Evaluate effectiveness and harms of interventions for patellar tendon related pain in children and adolescents. Design: Systematic review and meta-analysis. Data sources: Medline via Pubmed, Embase via OVID, CINAHL via Ebsco, SportDi... Read More about Therapeutic interventions in children and adolescents with patellar tendon related pain: a systematic review.

Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women (2018)
Journal Article
Sanchez-Santos, M., Judge, A., Gulati, M., Spector, T., Hart, D., Newton, J., …Kluzek, S. (2019). Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women. Seminars in Arthritis and Rheumatism, 48(5), 791-798. https://doi.org/10.1016/j.semarthrit.2018.07.007

Objective It is unclear whether the association between osteoarthritis (OA) and metabolic syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim was to describe the association between MetS and radiographic OA... Read More about Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women.

Partial mid-portion Achilles tear resulting in substantial improvement in pain and function in an amateur long-distance runner (2018)
Journal Article
Woyton, M. M., Kluzek, S., Wedatilake, T., & Davies, M. A. M. (2018). Partial mid-portion Achilles tear resulting in substantial improvement in pain and function in an amateur long-distance runner. BMJ Case Reports, 2018, Article bcr-2018-225823. https://doi.org/10.1136/bcr-2018-225823

This case presents symptom resolution for a long-distance runner with chronic Achilles tendinopathy (AT), following a partial tear of his Achilles tendon. The patient reported a sudden pain during a morning run, with preserved function. Three hours p... Read More about Partial mid-portion Achilles tear resulting in substantial improvement in pain and function in an amateur long-distance runner.

Confusion and abdominal symptoms following a rugby tackle (2017)
Journal Article
Ioannides, D., Davies, M., & Kluzek, S. (2017). Confusion and abdominal symptoms following a rugby tackle. BMJ Case Reports, 2017, Article bcr-2017-222160. https://doi.org/10.1136/bcr-2017-222160

A 19-year-old man was sent to the emergency department following a pitch-side assessment for suspected concussion, unexplained upper abdominal tenderness and vomiting, following a high-impact tackle during a rugby match. A Focussed Assessment with So... Read More about Confusion and abdominal symptoms following a rugby tackle.

A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis (2017)
Journal Article
McClelland, T. J., Penfold, R., Kluzek, S., & Nagra, N. S. (2017). A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis. BMJ Case Reports, 2017, Article bcr-2017-219350. https://doi.org/10.1136/bcr-2017-219350

Pericardial effusions arise as an extra-articular manifestation of rheumatoid arthritis (RA). Pericardial effusions are often asymptomatic, particularly in the early phase, but patients are at risk of cardiac tamponade as the effusion progresses. We... Read More about A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis.

Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy (2016)
Journal Article
Wallace, G., Cro, S., Doré, C., King, L., Kluzek, S., Price, A., …Arden, N. (2017). Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy. Arthritis Care and Research, 69(9), 1340-1348. https://doi.org/10.1002/acr.23162

Objective Painful knee osteoarthritis (KOA) has been associated with joint inflammation. There is, however, little literature correlating signs of localized inflammation with contrast‐enhanced (CE) magnetic resonance imaging (MRI) of synovium. Thi... Read More about Associations Between Clinical Evidence of Inflammation and Synovitis in Symptomatic Knee Osteoarthritis: A Cross-Sectional Substudy.

Markers of synovial inflammation in cohorts at risk of knee osteoarthritis (2016)
Thesis
Kluzek, S. (2016). Markers of synovial inflammation in cohorts at risk of knee osteoarthritis. (Thesis). University of Oxford. Retrieved from https://nottingham-repository.worktribe.com/output/4471293

Background and objectives. Knee osteoarthritis (KOA) is a leading cause of disability in the developed world. Additionally, it is possibly linked with premature mortality. Low-grade inflammation is associated with a high risk of non-traumatic KOA inc... Read More about Markers of synovial inflammation in cohorts at risk of knee osteoarthritis.

Suprapatellar synovial hypertrophy and reliability of the novel ultrasound assessment of suprapatellar recess in patients with recent knee injuries or early osteoarthritis (2016)
Journal Article
Kluzek, S., Wedatilake, T., McNally, E., Price, A., Judge, A., Watt, F., …Newton, J. (2016). Suprapatellar synovial hypertrophy and reliability of the novel ultrasound assessment of suprapatellar recess in patients with recent knee injuries or early osteoarthritis. Osteoarthritis and Cartilage, 24(S1), S299-S300. https://doi.org/10.1016/j.joca.2016.01.545

Purpose: Early through to late stage knee osteoarthritis (KOA) has been linked with effusion-synovitis in the suprapatellar pouch and chronic inflammation has been particularly associated with pain. Recent studies also suggest that synovial hypertrop... Read More about Suprapatellar synovial hypertrophy and reliability of the novel ultrasound assessment of suprapatellar recess in patients with recent knee injuries or early osteoarthritis.

Response to: ‘Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women’ by Gao et al (2016)
Journal Article
Kluzek, S., Sanchez-Santos, M. T., Leyland, K. M., Judge, A., Newton, J., & Arden, N. K. (2016). Response to: ‘Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women’ by Gao et al. Annals of the Rheumatic Diseases, 75(4), Article e23. https://doi.org/10.1136/annrheumdis-2015-209029

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women (2015)
Journal Article
Kluzek, S., Bay-Jensen, A., Judge, A., Karsdal, M. A., Shorthose, M., Spector, T., …Arden, N. K. (2015). Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women. Biomarkers, 20(8), 557-564. https://doi.org/10.3109/1354750x.2015.1105498

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged... Read More about Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women.

Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23?years follow-up of a population-based cohort of middle-aged women (2015)
Journal Article
Kluzek, S., Sanchez-Santos, M. T., Leyland, K. M., Judge, A., Spector, T. D., Hart, D., …Arden, N. K. (2016). Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women. Annals of the Rheumatic Diseases, 75(10), 1749-1756. https://doi.org/10.1136/annrheumdis-2015-208056

To assess whether joint pain or radiographic osteoarthritis (ROA) of the knee and hand is associated with all-cause and disease-specific mortality in middle-aged women. Methods: Four subgroups from the prospective community-based Chingford Cohort... Read More about Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23?years follow-up of a population-based cohort of middle-aged women.

Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis (2015)
Journal Article
Williamson, W., Kluzek, S., Roberts, N., Richards, J., Arden, N., Leeson, P., …Foster, C. (2015). Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis. BMJ Open, 5(8), Article e007642. https://doi.org/10.1136/bmjopen-2015-007642

Objective: To assess effectiveness of osteoarthritis interventions to promote long-term physical activity behaviour change. Design: A systematic review and meta-analysis. Protocol registration PROSPERO CRD4201300444 5 (http://www.crd.york.ac.uk/pr... Read More about Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis.

Is osteoarthritis a metabolic disorder? (2015)
Journal Article
Kluzek, S., Newton, J. L., & Arden, N. K. (2015). Is osteoarthritis a metabolic disorder?. British Medical Bulletin, 115(1), 111-121. https://doi.org/10.1093/bmb/ldv028

Background Obesity is associated with an increased risk of developing osteoarthritis (OA), even in non-weight bearing joints. High levels of adipose tissue-associated inflammation may explain this association. Sources of data and areas of debat... Read More about Is osteoarthritis a metabolic disorder?.

Adipokines as potential prognostic biomarkers in patients with acute knee injury (2015)
Journal Article
Kluzek, S., Arden, N. K., & Newton, J. (2015). Adipokines as potential prognostic biomarkers in patients with acute knee injury. Biomarkers, 20(8), 519-525. https://doi.org/10.3109/1354750x.2014.948914

This review considers adipokines as predictive biomarkers for early onset post-traumatic knee osteoarthritis (KOA). Serum concentrations of leptin and resistin can predict radiographic changes and are elevated in early KOA, with higher leptin concent... Read More about Adipokines as potential prognostic biomarkers in patients with acute knee injury.